Responsivity and Reproducibility of Sputum Inflammatory Biomarkers During COPD Exacerbation and Stable Phases – A Pilot Study

Autor: Ditz B, Kistemaker LEM, van den Berge M, Vonk JM, Gosens R, Kerstjens HAM

Publikováno v: International Journal of COPD, Vol Volume 16, Pp 3055-3064 (2021)

B Ditz,1,2 LEM Kistemaker,2– 4 M van den Berge,1,2 JM Vonk,2,5 R Gosens,2,3 HAM Kerstjens1,2 1Department of Pulmonary Diseases, University Medical Center, University of Groningen, Groningen, the Netherlands; 2Groningen Research Institute for Asthma

Externí odkaz: https://doaj.org/article/1978bbcb3a614215800f9ba29702746c

HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice.

Autor: Leus NG; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., van den Bosch T; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., van der Wouden PE; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Krist K; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Ourailidou ME; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Eleftheriadis N; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Kistemaker LE; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Bos S; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Gjaltema RA; Department of Pathology &Medical Biology, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands., Mekonnen SA; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Bischoff R; Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Gosens R; Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Haisma HJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands., Dekker FJ; Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2017 Mar 27; Vol. 7, pp. 45047. Date of Electronic Publication: 2017 Mar 27.

Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.

Autor: Hiorns JE; School of Mathematical Sciences, University of Nottingham Nottingham, UK., Bidan CM; Laboratoire Interdisciplinaire de Physique, Centre National de la Recherche Scientifique, Université Grenoble AlpesGrenoble, France; Department of Molecular Pharmacology, University of GroningenGroningen, Netherlands; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolBoston, MA, USA., Jensen OE; School of Mathematics, University of Manchester Manchester, UK., Gosens R; Department of Molecular Pharmacology, University of Groningen Groningen, Netherlands., Kistemaker LE; Department of Molecular Pharmacology, University of Groningen Groningen, Netherlands., Fredberg JJ; Department of Environmental Health, Harvard School of Public Health Boston, MA, USA., Butler JP; Department of Environmental Health, Harvard School of Public Health Boston, MA, USA., Krishnan R; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA, USA., Brook BS; School of Mathematical Sciences, University of Nottingham Nottingham, UK.

Publikováno v: Frontiers in physiology [Front Physiol] 2016 Jul 21; Vol. 7, pp. 309. Date of Electronic Publication: 2016 Jul 21 (Print Publication: 2016).

Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma.

Autor: Kistemaker LE; Department of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands. l.e.m.kistemaker@rug.nl.; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. l.e.m.kistemaker@rug.nl., Bos IS; Department of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Menzen MH; Department of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Maarsingh H; Department of Pharmaceutical Sciences, Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA., Meurs H; Department of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Gosens R; Department of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands.; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: Respiratory research [Respir Res] 2016 Feb 04; Vol. 17, pp. 13. Date of Electronic Publication: 2016 Feb 04.

Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.

Autor: Kistemaker LE; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Hiemstra PS; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands., Bos IS; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bouwman S; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van den Berge M; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Hylkema MN; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands., Meurs H; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Kerstjens HA; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Gosens R; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: Thorax [Thorax] 2015 Jul; Vol. 70 (7), pp. 668-76. Date of Electronic Publication: 2015 May 20.