Combination treatment to improve mucociliary transport of Pseudomonas aeruginosa biofilms.

Autor: Rouillard KR; Marsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC, United States of America., Esther CP; Marsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC, United States of America., Kissner WJ; Marsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC, United States of America., Plott LM; Marsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC, United States of America., Bowman DW; Marsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC, United States of America., Markovetz MR; Marsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC, United States of America., Hill DB; Marsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC, United States of America.; Joint Department of Biomedical Engineering, UNC Chapel Hill, Chapel Hill, NC, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Feb 23; Vol. 19 (2), pp. e0294120. Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024).

Normalizing salt content by mixing native human airway mucus samples normalizes sample rheology.

Autor: Markovetz MR; Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Hibbard JE; Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Plott LM; Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Bacudio LG; Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Kissner WJ; Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Ghio A; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Chapel Hill, NC, United States., Kumar PA; Department of Anesthesiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Outcomes Research Consortium, Cleveland, OH, United States., Arora H; Department of Anesthesiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Outcomes Research Consortium, Cleveland, OH, United States., Hill DB; Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.; Joint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Publikováno v: Frontiers in physiology [Front Physiol] 2023 Mar 10; Vol. 14, pp. 1111647. Date of Electronic Publication: 2023 Mar 10 (Print Publication: 2023).

Mucus and mucus flake composition and abundance reflect inflammatory and infection status in cystic fibrosis.

Autor: Markovetz MR; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA. Electronic address: matthew_markovetz@med.unc.edu., Garbarine IC; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA., Morrison CB; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA., Kissner WJ; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA., Seim I; Department of Mathematics, University of North Carolina, Chapel Hill, USA; Department of Applied Physical Sciences, University of North Carolina, Chapel Hill, USA., Forest MG; Department of Mathematics, University of North Carolina, Chapel Hill, USA; Department of Applied Physical Sciences, University of North Carolina, Chapel Hill, USA; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, USA., Papanikolas MJ; Department of Applied Physical Sciences, University of North Carolina, Chapel Hill, USA., Freeman R; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA; Department of Applied Physical Sciences, University of North Carolina, Chapel Hill, USA., Ceppe A; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA., Ghio A; National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, University of North Carolina, Chapel Hill, USA., Alexis NE; Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina, Chapel Hill, USA., Stick SM; Telethon Kids Institute, University of Western Australia, Perth, Australia; Division of Pediatrics, University of Western Australia, Perth, Australia; Princess Margaret Hospital for Children, Perth, Australia., Ehre C; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA., Boucher RC; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA., Esther CR; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA; Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Muhlebach MS; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA; Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Hill DB; Marsico Lung Institute, University of North Carolina, Chapel Hill, USA; Department of Physics and Astrophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: david_b_hill@med.unc.edu.

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2022 Nov; Vol. 21 (6), pp. 959-966. Date of Electronic Publication: 2022 Apr 16.

Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds.

Autor: Schiller JL; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Fogle MM; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bussey O; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kissner WJ; Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hill DB; Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Marsico Lung Institute/CF Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lai SK; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: lai@unc.edu.

Publikováno v: Acta biomaterialia [Acta Biomater] 2020 Apr 15; Vol. 107, pp. 91-101. Date of Electronic Publication: 2020 Mar 05.

Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice.

Autor: Hancock LA; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Hennessy CE; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Solomon GM; Department of Medicine, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, 35294, USA., Dobrinskikh E; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Estrella A; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Hara N; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Hill DB; Marsico Lung Institute, University of North Carolina, Chapel Hill, NC, 27599, USA.; Physics and Astronomy, University of North Carolina, Chapel Hill, NC, 27599, USA., Kissner WJ; Marsico Lung Institute, University of North Carolina, Chapel Hill, NC, 27599, USA., Markovetz MR; Marsico Lung Institute, University of North Carolina, Chapel Hill, NC, 27599, USA., Grove Villalon DE; Parion Sciences, Inc, Durham, NC, 27713, USA., Voss ME; Parion Sciences, Inc, Durham, NC, 27713, USA., Tearney GJ; Wellman Center for Photomedicine and Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Carroll KS; Department of Chemistry, The Scripps Research Institute, Jupiter, FL, 33458, USA., Shi Y; Department of Chemistry, The Scripps Research Institute, Jupiter, FL, 33458, USA., Schwarz MI; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Thelin WR; Parion Sciences, Inc, Durham, NC, 27713, USA., Rowe SM; Department of Medicine, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, 35294, USA., Yang IV; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Evans CM; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA.; Department of Immunology, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA., Schwartz DA; Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA. david.schwartz@ucdenver.edu.; Department of Immunology, University of Colorado Denver, School of Medicine, Aurora, CO, 80045, USA. david.schwartz@ucdenver.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Dec 18; Vol. 9 (1), pp. 5363. Date of Electronic Publication: 2018 Dec 18.