Development of a sensitive and quantitative UHPLC-MS/MS method to study the whole-body uptake of pharmaceuticals in zebrafish

Autor: Kislyuk, Stanislav ^a, Kroonen, Jerome ^b, Adams, Erwin ^a, Augustijns, Patrick ^c, de Witte, Peter ^d, Cabooter, Deirdre ^{a, ⁎}

Publikováno v: In Talanta 1 November 2017 174:780-788

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

Autor: Xuan-Bac Nguyen¹ bac.nguyenxuan@kuleuven.be, Kislyuk, Stanislav² stanislav.kislyuk@kuleuven.be, Duc-Hung Pham¹ duchung.pham@kuleuven.be, Kecskés, Angela¹ angela.kecskes@aok.pte.hu, Maes, Jan¹ jan.maes@kuleuven.be, Cabooter, Deirdre² deirdre.cabooter@kuleuven.be, Annaert, Pieter³ pieter.annaert@kuleuven.be, De Witte, Peter¹ peter.dewitte@kuleuven.be, Ny, Annelii¹ annelii.ny@kuleuven.be

Publikováno v: International Journal of Molecular Sciences. Feb2017, Vol. 18 Issue 2, p356. 17p.

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

Autor: Nguyen XB; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 824, 3000 Leuven, Belgium. bac.nguyenxuan@kuleuven.be., Kislyuk S; Division Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 923, 3000 Leuven, Belgium. stanislav.kislyuk@kuleuven.be., Pham DH; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 824, 3000 Leuven, Belgium. duchung.pham@kuleuven.be., Kecskés A; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 824, 3000 Leuven, Belgium. angela.kecskes@aok.pte.hu., Maes J; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 824, 3000 Leuven, Belgium. jan.maes@kuleuven.be., Cabooter D; Division Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 923, 3000 Leuven, Belgium. deirdre.cabooter@kuleuven.be., Annaert P; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 921, 3000 Leuven, Belgium. pieter.annaert@kuleuven.be., De Witte P; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 824, 3000 Leuven, Belgium. peter.dewitte@kuleuven.be., Ny A; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-box 824, 3000 Leuven, Belgium. annelii.ny@kuleuven.be.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2017 Feb 08; Vol. 18 (2). Date of Electronic Publication: 2017 Feb 08.