Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kishore V. Kuchibhotla"'
Autor:
Sharlen Moore, Kishore V. Kuchibhotla
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 9-14 (2022)
Learning is fundamental to animal survival. Animals must learn to link sensory cues in the environment to actions that lead to reward or avoid punishment. Rapid learning can then be highly adaptive and the difference between life or death. To explore
Externí odkaz:
https://doaj.org/article/6145fa497e594fd883ac27bc11a3040e
Autor:
Kishore V. Kuchibhotla, Tom Hindmarsh Sten, Eleni S. Papadoyannis, Sarah Elnozahy, Kelly A. Fogelson, Rupesh Kumar, Yves Boubenec, Peter C. Holland, Srdjan Ostojic, Robert C. Froemke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Performance is generally used as a metric to assay whether an animal has learnt a particular perceptual task. Here the authors demonstrate that in the context of probe trials without the possibility of reward, animals perform the correct instrumental
Externí odkaz:
https://doaj.org/article/8d6163e479184fb98ad664b86df73699
Publikováno v:
Nature Neuroscience. 26:810-819
Autor:
Kishore V. Kuchibhotla, Tom Hindmarsh Sten, Eleni S. Papadoyannis, Sarah Elnozahy, Kelly A. Fogelson, Rupesh Kumar, Yves Boubenec, Peter C. Holland, Srdjan Ostojic, Robert C. Froemke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/bba7cf3bbf2747d5ae13ea84a84553f4
Cholinergic basal forebrain (CBF) signaling exhibits multiple timescales of activity with classic, slow signals related to brain and behavioral states and faster, phasic signals reflecting behavioral events, including movement and reinforcement. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c2543c1ce1bfc10997fa03dc1effcd4
https://doi.org/10.1101/2022.05.05.490613
https://doi.org/10.1101/2022.05.05.490613
Autor:
Peter C. Holland, Eleni S. Papadoyannis, Srdjan Ostojic, Tom Hindmarsh Sten, Rupesh Kumar, Robert C. Froemke, Sarah Elnozahy, Kelly Fogelson, Kishore V. Kuchibhotla, Yves Boubenec
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-10089-0⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-10089-0⟩
SUMMARYPerformance on cognitive tasks during learning is used to measure intelligence, yet it remains controversial since such testing is susceptible to contextual factors. To what extent does performance during learning depend on the testing context
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Kelly Fogelson, Rupesh Kumar, Robert C. Froemke, Kishore V. Kuchibhotla, Peter C. Holland, Tom Hindmarsh Sten, Eleni S. Papadoyannis, Yves Boubenec, Sarah Elnozahy, Srdjan Ostojic
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Performance on cognitive tasks during learning is used to measure knowledge, yet it remains controversial since such testing is susceptible to contextual factors. To what extent does performance during learning depend on the testing context, rather t
Publikováno v:
Nature Neuroscience. 20:1199-1208
Neocortical inhibitory neurons exhibit remarkably diverse morphology, physiological properties and connectivity. Genetic access to molecularly-defined subtypes of inhibitory neurons has aided their functional characterization in recent years. These s
Autor:
Tara L. Spires-Jones, Claudia Cannavo, Bradley T. Hyman, Taylie Sargent, Rebecca A. Betensky, Jacob Aaron Klickstein, Kishore V. Kuchibhotla, Eloise Hudry, Alona Muzikansky, Lauren Wrobleski, Allyson D. Roe, David Urick, Steven S. Hou, Rosemary J. Jackson, Sheetal Gandhi
Publikováno v:
Life Science Alliance
Hudry, E, Klickstein, J, Cannavo, C, Jackson, R, Muzikansky, A, Gandhi, S, Urick, D, Sargent, T, Wrobleski, L, Roe, A D, Hou, S S, Kuchibhotla, K V, Betensky, R A, Spires-Jones, T & Hyman, B T 2019, ' Opposing Roles of apolipoprotein E in aging and neurodegeneration ', Life Science Alliance, vol. 2, no. 1 . https://doi.org/10.26508/lsa.201900325
Hudry, E, Klickstein, J, Cannavo, C, Jackson, R, Muzikansky, A, Gandhi, S, Urick, D, Sargent, T, Wrobleski, L, Roe, A D, Hou, S S, Kuchibhotla, K V, Betensky, R A, Spires-Jones, T & Hyman, B T 2019, ' Opposing Roles of apolipoprotein E in aging and neurodegeneration ', Life Science Alliance, vol. 2, no. 1 . https://doi.org/10.26508/lsa.201900325
This study investigates how APOE modulates neuronal function integrity during normal aging and in the context of amyloidosis. This work demonstrates that APOE is a necessary partner of Aβ-dependent neuronal dysfunction and synaptotoxicity but also p