Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kishore B. Challagundla"'
Autor:
Anup S. Pathania, Haritha Chava, Nagendra K. Chaturvedi, Srinivas Chava, Siddappa N. Byrareddy, Don W. Coulter, Kishore B. Challagundla
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-16 (2024)
Abstract Neuroblastoma (NB) is a highly aggressive pediatric cancer that originates from immature nerve cells, presenting significant treatment challenges due to therapy resistance. Despite intensive treatment, approximately 50% of high-risk NB cases
Externí odkaz:
https://doaj.org/article/226c2af1afc4471e87df8788cc1ced8c
Autor:
Philip Prathipati, Anup S. Pathania, Nagendra K. Chaturvedi, Subash C. Gupta, Siddappa N. Byrareddy, Don W. Coulter, Kishore B. Challagundla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 101543- (2024)
Neuroblastoma is the most devastating extracranial solid malignancy in children. Despite an intense treatment regimen, the prognosis for high-risk neuroblastoma patients remains poor, with less than 40% survival. So far, MYCN amplification status is
Externí odkaz:
https://doaj.org/article/7d9eb9261b3e4d0b860be7a5cf90ac13
Autor:
Matthew J. Kling, Varun Kesherwani, Nitish K. Mishra, Gracey Alexander, Erin M. McIntyre, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)
Abstract Background Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor clinical outcomes and respond poorly to current therapies. Epigenetic deregulation is very common in MYC-driven MB. The bromodo
Externí odkaz:
https://doaj.org/article/74ff7cb36dd04e48ba6d2bd841e3e5f5
Autor:
Anup S. Pathania, Philip Prathipati, Omalla A. Olwenyi, Srinivas Chava, Oghenetejiri V. Smith, Subash C. Gupta, Nagendra K. Chaturvedi, Siddappa N. Byrareddy, Don W. Coulter, Kishore B. Challagundla
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 308-329 (2022)
Neuroblastoma (NB) is an enigmatic and deadliest pediatric cancer to treat. The major obstacles to the effective immunotherapy treatments in NB are defective immune cells and the immune evasion tactics deployed by the tumor cells and the stromal micr
Externí odkaz:
https://doaj.org/article/bc3461424d0e4c1087e702fa93012a6c
Autor:
Matthew J. Kling, Connor N. Griggs, Erin M. McIntyre, Gracey Alexander, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes. PI3K-mTOR signaling-driven deregulation of protein synthesis is very common in
Externí odkaz:
https://doaj.org/article/1e0bff91543c41f7aa95510776436cfe
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 1371-1383 (2021)
Recent advances in exosome biology have uncovered a significant role of exosomes in cancer and make them a determining factor in intercellular communication. Exosomes are types of extracellular vesicles that are involved in the communication between
Externí odkaz:
https://doaj.org/article/6d9b36e3003445f3b4e4a09d3b3324da
Autor:
Weam Othman Elbezanti, Kishore B. Challagundla, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 415 (2023)
Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free surv
Externí odkaz:
https://doaj.org/article/ab2e1b0464064d68991d012df6bd5c4a
Autor:
Srinivas Chava, C. Patrick Reynolds, Anup S. Pathania, Santhi Gorantla, Larisa Y. Poluektova, Don W. Coulter, Subash C. Gupta, Manoj K. Pandey, Kishore B. Challagundla
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 180-196 (2020)
Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite current aggressive treatment regimens, the prognosis for high‐risk NB patients remains poor, with the survival of less than 40%. Amplification/stabilization of
Externí odkaz:
https://doaj.org/article/d123863f70384ad887db192bc2a7c795
Autor:
Ivan Vannini, Petra M. Wise, Kishore B. Challagundla, Meropi Plousiou, Mirco Raffini, Erika Bandini, Francesca Fanini, Giorgia Paliaga, Melissa Crawford, Manuela Ferracin, Cristina Ivan, Linda Fabris, Ramana V. Davuluri, Zhiyi Guo, Maria Angelica Cortez, Xinna Zhang, Lu Chen, Shuxing Zhang, Cecilia Fernandez-Cymering, Leng Han, Silvia Carloni, Samanta Salvi, Hui Ling, Mariam Murtadha, Paolo Neviani, Barbara J. Gitlitz, Ite A. Laird-Offringa, Patrick Nana-Sinkam, Massimo Negrini, Han Liang, Dino Amadori, Amelia Cimmino, George A. Calin, Muller Fabbri
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cycl
Externí odkaz:
https://doaj.org/article/20f421d598244afda24290cb099f73c7
Autor:
Max Von Suskil, Kazi Nasrin Sultana, Weam Othman Elbezanti, Omar S. Al-Odat, Robert Chitren, Amit K. Tiwari, Kishore B. Challagundla, Sandeep Kumar Srivastava, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K. Pandey
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5707 (2021)
Multiple myeloma (MM), a clonal plasma cell disorder, disrupts the bones’ hematopoiesis and microenvironment homeostasis and ability to mediate an immune response against malignant clones. Despite prominent survival improvement with newer treatment
Externí odkaz:
https://doaj.org/article/b26cc9bd38c74bec9e24eaac4808073d