Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kiryanov, Andre"'
Autor:
Williams, David R., Kiryanov, Andre A., Emde, Ulrich, Clark, Michael P., Berliner, Martin A., Reeves, Jonathan T., Nicolaou, Kyriacos C.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2004 Aug . 101(33), 12058-12063.
Externí odkaz:
https://www.jstor.org/stable/3373089
Autor:
Kiryanov, Andre, Natala, Srinivasa, Jones, Benjamin, McBride, Christopher, Feher, Victoria, Lam, Betty, Liu, Yan, Honda, Kouhei, Uchiyama, Noriko, Kawamoto, Tomohiro, Hikichi, Yuichi, Zhang, Lilly, Hosfield, David, Skene, Robert, Zou, Hua, Stafford, Jeffrey, Cao, Xiaodong, Ichikawa, Takashi
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 March 2017 27(5):1311-1315
Autor:
Keung, Walter, Boloor, Amogh, Brown, Jason, Kiryanov, Andre, Gangloff, Anthony, Lawson, J. David, Skene, Robert, Hoffman, Isaac, Atienza, Josephine, Kahana, Jason, De Jong, Ron, Farrell, Pamela, Balakrishna, Deepika, Halkowycz, Petro
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 February 2017 27(4):1099-1104
Publikováno v:
In Tetrahedron 2001 57(27):5757-5767
Autor:
Charles E. Grimshaw, Isabelle Tcholakov, Lihong Shi, Kiryanov Andre A, Artur Plonowski, Murphy Sean, Jacques Ermolieff, Christopher J. Larson
Publikováno v:
Bioscience Reports
Prolyl hydroxylases (PHDs) down-regulate the level of hypoxia-inducible factors (HIFs) by hydroxylating key proline residues that trigger the degradation of the protein and affect the cell and its ability to respond to hypoxic stress. Several small m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df965c862d79fda155242ac015bbda5d
http://europepmc.org/articles/PMC6434079
http://europepmc.org/articles/PMC6434079
Autor:
Phong H. Vu, Anthony R. Gangloff, Ron de Jong, Mark S. Hixon, Ruhi Kamran, Charles E. Grimshaw, Douglas R. Dougan, Ewan Taylor, Shawn M. O’Connell, Andrew John Jennings, Jason W. Brown, Kiryanov Andre A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4501-4505
Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b84c1ed208d3a61d59a2f2958ac618
https://doi.org/10.1016/j.bmcl.2013.06.055
https://doi.org/10.1016/j.bmcl.2013.06.055
Autor:
Shin-ichi Matsumoto, Jeffrey A. Stafford, Betty Lam, Zhe Nie, Noriko Uchiyama, Yan Liu, Lilly Zhang, Koki Hikami, Feher Victoria, Kiryanov Andre A, Nobuyuki Amano, David J. Hosfield, Srinivasa Reddy Natala, Robert J. Skene, Xiaodong Cao, Hua Zou, Christopher McBride, Yuichi Hikichi, Tomohiro Kawamoto, Stephen W. Kaldor, Takashi Ichikawa, Jones Benjamin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3662-3666
Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::095c494559927c4501b2a27cf758bee3
https://doi.org/10.1016/j.bmcl.2013.02.083
https://doi.org/10.1016/j.bmcl.2013.02.083
Autor:
Josephine Atienza, Isaac Hoffman, Jason Kahana, Deepika Balakrishna, Ron de Jong, Amogh Boloor, Walter Keung, Petro Halkowycz, Kiryanov Andre A, J. David Lawson, Anthony R. Gangloff, Jason W. Brown, Pamela Farrell, Robert J. Skene
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(4)
Axl has been a target of interest in the oncology field for several years based on its role in various oncogenic processes. To date, no wild-type Axl crystal structure has been reported. Herein, we describe the structure-based optimization of a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84146fc25876e811144f0d269a6346cf
https://pubmed.ncbi.nlm.nih.gov/28082036
https://pubmed.ncbi.nlm.nih.gov/28082036
Autor:
Kouhei Honda, Betty Lam, Xiaodong Cao, Tomohiro Kawamoto, David J. Hosfield, Takashi Ichikawa, Hua Zou, Srinivasa Reddy Natala, Kiryanov Andre A, Jones Benjamin, Yuichi Hikichi, Robert J. Skene, Jeffrey A. Stafford, Feher Victoria, Christopher McBride, Noriko Uchiyama, Yan Liu, Lilly Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine PLK1 inhibitors. Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8509d8ca6026c869b9f2b4ac622c74c4
https://pubmed.ncbi.nlm.nih.gov/28169164
https://pubmed.ncbi.nlm.nih.gov/28169164
Publikováno v:
Liquid Crystals. 36:443-453
The synthesis of the first series of 5-alkoxy-1,3-thiazole-based liquid crystals is reported. The aforementioned liquid crystals were synthesised through a Lawesson's reagent-mediated cyclisation of appropriate α-benzamido esters. This methodology w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebee1d88de5d53c8b9fc9ccdcf8faf54
https://doi.org/10.1080/02678290903003121
https://doi.org/10.1080/02678290903003121