Výsledky vyhledávání - "Kirwin M, Providence"

PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair

Autor: Paul J. Higgins, Kirwin M. Providence

Publikováno v: Journal of Cellular Physiology. 200:297-308

Several proteases and their specific inhibitors modulate the interdependent processes of cell migration and matrix proteolysis as part of the global program of trauma repair. Expression of plasminogen activator inhibitor type-1 (PAI-1), a serine prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a13a02a3a2ead344dc8b3baaefbee3
https://doi.org/10.1002/jcp.20016

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PLASMOLYSIS, HECHTIAN STRAND FORMATION, AND LOCALIZED MEMBRANE-WALL ADHESIONS IN THE DESMID, CLOSTERIUM ACEROSUM (CHLOROPHYTA)1

Autor: Rachael Roberts, Carey Danyow, Brennan Smith, David S. Domozych, Rebecca Flitter, Kirwin M. Providence

Publikováno v: Journal of Phycology. 39:1194-1206

Closterium acerosum Ehrenberg (Chlorophyta) produced a distinct network of thin cytoplasmic strands, or Hechtian strands, upon controlled plasmolysis in a sucrose solution. The strands persisted for 30 min or longer and could be visualized with both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e4528c44b30998d027f35a872f4aba5
https://doi.org/10.1111/j.0022-3646.2003.03-033.x

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Antisense targeting of c-fos transcripts inhibits serum- and TGF-?1-stimulated PAI-1 gene expression and directed motility in renal epithelial cells

Autor: Stacie M. Kutz, Kirwin M. Providence, Paul J. Higgins

Publikováno v: Cell Motility and the Cytoskeleton. 48:163-174

Plasminogen activator inhibitor type-1 (PAI-1), the major regulator of pericellular plasmin generation, and the c-FOS transcription factor are expressed by migrating cells in response to monolayer wounding. Induced c-fos and PAI-1 transcripts were ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76a9d60cb384b2600d90b9079fcb4fab
https://doi.org/10.1002/1097-0169(200103)48:3<163::aid-cm1006>3.0.co

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PAI-1 gene expression is regionally induced in wounded epithelial cell monolayers and required for injury repair

Autor: Paul J. Higgins, Lisa Staiano-Coico, Stacie M. Kutz, Kirwin M. Providence

Publikováno v: Journal of Cellular Physiology. 182:269-280

Induced expression of plasminogen activator inhibitor type-1 (PAI-1), a major negative regulator of pericellular plasmin generation, accompanies wound repair in vitro and in vivo. Since transcriptional control of the PAI-1 gene is superimposed on a g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3272030c9f8720d643aaf1896aa83cca
https://doi.org/10.1002/(sici)1097-4652(200002)182:2<269::aid-jcp16>3.0.co

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Perturbation of the actin cytoskeleton induces PAI-1 gene expression in cultured epithelial cells independent of substrate anchorage

Autor: Paul J. Higgins, Kirwin M. Providence, Stacie M. Kutz

Publikováno v: Cell Motility and the Cytoskeleton. 42:218-229

Perturbation of cellular architecture with agents that alter cytoskeletal organization provides a means to assess the relationship between cell shape and gene expression. Induced transcription of the plasminogen activator inhibitor type-1 (PAI-1) gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dada673538638abd1b354e26f6547e58
https://doi.org/10.1002/(sici)1097-0169(1999)42:3<218::aid-cm5>3.0.co

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SERPINE1 (PAI-1) is deposited into keratinocyte migration 'trails' and required for optimal monolayer wound repair

Autor: Craig E. Higgins, Andrew R. Mullen, Paul J. Higgins, Rohan Samarakoon, Stephen P. Higgins, Kirwin M. Providence, Cynthia E. Wilkins-Port, Ashley Battista

Publikováno v: Archives of dermatological research. 300(6)

Cutaneous tissue injury, both in vivo and in vitro, initiates activation of a "wound repair" transcriptional program. One such highly induced gene encodes plasminogen activator inhibitor type-1 (PAI-1, SERPINE1). PAI-1-GFP, expressed as a fusion prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af7f1f5ba2d022ee3bfd56002c74862
https://pubmed.ncbi.nlm.nih.gov/18386027

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Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis

Autor: Kristin K, Nelson, Aparna C, Ranganathan, Jelriza, Mansouri, Ana M, Rodriguez, Kirwin M, Providence, Joni L, Rutter, Kevin, Pumiglia, James A, Bennett, J Andres, Melendez

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(1)

Elevated manganese superoxide dismutase (Sod2) levels have been reported to be associated with an increased frequency of tumor invasion and metastasis in certain cancers, and the aim of this study is to examine the molecular mechanisms by which this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad2aa4a15390ac813c9342c84ab7594b
https://pubmed.ncbi.nlm.nih.gov/12538496

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Epithelial monolayer wounding stimulates binding of USF-1 to an E-box motif in the plasminogen activator inhibitor type 1 gene

Autor: Kirwin M. Providence, Paul J. Higgins, Lisa Staiano-Coico, Jianzhong Tang, John Gonclaves, Lisa A. White

Publikováno v: Journal of cell science. 115(Pt 19)

Several proteases and their co-expressed inhibitors modulate the interdependent processes of cell migration and matrix proteolysis during wound repair. Transcription of the gene encoding plasminogen activator inhibitor type 1 (PAI-1), a serine protea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479a95589f7ddf6788ceee2e49872e58
https://pubmed.ncbi.nlm.nih.gov/12235287

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