MMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas

Autor: Gill, Jason H., Kirwan, Ian G., Seargent, Jill M., Martin, Sandie W., Tijani, S., Anikin, V.A., Mearns, A.J., Bibby, Michael C., Anthoney, Alan, Loadman, Paul

Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type t

Externí odkaz: http://hdl.handle.net/10454/4121

Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate.

Autor: Loadman, Paul M., Bibby, Michael C., Shnyder, Steven D., Swaine, David J., Kirwan, Ian G., Anthoney, Alan, Cooper, Patricia A., Lippert, J.W.

Purpose: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical

Externí odkaz: http://hdl.handle.net/10454/2953

MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.

Autor: Gill JH; Cancer Research UK Laboratories, Tom Connors Cancer Research Centre, University of Bradford, Bradford BD7 1DP, UK. j.gill1@bradford.ac.uk, Kirwan IG, Seargent JM, Martin SW, Tijani S, Anikin VA, Mearns AJ, Bibby MC, Anthoney A, Loadman PM

Publikováno v: Neoplasia (New York, N.Y.) [Neoplasia] 2004 Nov-Dec; Vol. 6 (6), pp. 777-85.