Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Kirwan, Ian G."'
1
Akademický článek
MMP-10 is overexpressed, proteolytically active and a potential target for therapeutic intervention in human lung carcinomas
Autor: Gill, Jason H., Kirwan, Ian G., Seargent, Jill M., Martin, Sandie W., Tijani, S., Anikin, V.A., Mearns, A.J., Bibby, Michael C., Anthoney, Alan, Loadman, Paul
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type t
Externí odkaz: http://hdl.handle.net/10454/4121
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2
Akademický článek
Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate
Autor: Kirwan, Ian G., Loadman, Paul, Swaine, David J., Anthoney, Alan, Pettit, G.R., Lippert III, J.W., Shnyder, Steven, Cooper, Patricia A., Bibby, Michael C.
Purpose: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical
Externí odkaz: http://hdl.handle.net/10454/13684
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3
Akademický článek
Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate.
Autor: Loadman, Paul M., Bibby, Michael C., Shnyder, Steven D., Swaine, David J., Kirwan, Ian G., Anthoney, Alan, Cooper, Patricia A., Lippert, J.W.
Purpose: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical
Externí odkaz: http://hdl.handle.net/10454/2953
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4
MMP-10 Is Overexpressed, Proteolytically Active, and a Potential Target for Therapeutic Intervention in Human Lung Carcinomas1
Autor: Gill, Jason H, Kirwan, Ian G, Seargent, Jill M, Martin, Sandie W, Tijani, Sidiq, Anikin, Vladimir A, Mearns, Alan J, Bibby, Michael C, Anthoney, Alan, Loadman, Paul M
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor development and expansion. This study analysed MMP-10 protein expression and activity in human lung tumors of various grade, stage, and type t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::361a1fb2f4691c39dd7c1b830d923063
https://europepmc.org/articles/PMC1550316/
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