Disease-Inspired Design of Biomimetic Tannic Acid-Based Hybrid Nanocarriers for Enhancing the Treatment of Bacterial-Induced Sepsis.

Autor: Elhassan E; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag Durban X54001, South Africa., Omolo CA; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag Durban X54001, South Africa.; Department of Pharmaceutics and Pharmacy Practice, School of Pharmacy and Health Sciences, United States International University-Africa, P.O. Box 14634-00800, Nairobi 00800, Kenya., Gafar MA; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag Durban X54001, South Africa.; Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum 11111, Sudan., Kiruri LW; Department of Chemistry, Kenyatta University, P.O. Box 43844, Nairobi 00100, Kenya., Ibrahim UH; Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4300, South Africa., Ismail EA; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag Durban X54001, South Africa., Devnarain N; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag Durban X54001, South Africa., Govender T; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag Durban X54001, South Africa.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Oct 07; Vol. 21 (10), pp. 4924-4946. Date of Electronic Publication: 2024 Aug 30.

Hydrophobic π-π stacking interactions and hydrogen bonds drive self-aggregation of luteolin in water.

Autor: Deogratias G; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania. Electronic address: dgeradius@udsm.ac.tz., Shadrack DM; Department of Chemistry, Faculty of Natural and Applied Sciences, St. John's University of Tanzania, P.O. Box 47, Dodoma, Tanzania., Munissi JJE; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Kinunda GA; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Jacob FR; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Mtei RP; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Masalu RJ; Department of Molecular Biology and Biotechnology, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 25179, Dar es Salaam, Tanzania., Mwakyula I; Mbeya College of Health and Allied Sciences, University of Dar es Salaam, P.O. Box 608, Mbeya, Tanzania., Kiruri LW; Department of Chemistry, Kenyatta University, P.O.Box, 43844-00100, Nairobi, Kenya., Nyandoro SS; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania.

Publikováno v: Journal of molecular graphics & modelling [J Mol Graph Model] 2022 Nov; Vol. 116, pp. 108243. Date of Electronic Publication: 2022 Jun 23.

Cation-π interactions drive hydrophobic self-assembly and aggregation of niclosamide in water.

Autor: Vuai SAH; Department of Chemistry, College of Natural and Mathematical Sciences, University of Dodoma P. O. Box 338 Dodoma Tanzania., Sahini MG; Department of Chemistry, College of Natural and Mathematical Sciences, University of Dodoma P. O. Box 338 Dodoma Tanzania., Onoka I; Department of Chemistry, College of Natural and Mathematical Sciences, University of Dodoma P. O. Box 338 Dodoma Tanzania., Kiruri LW; Department of Chemistry, Kenyatta University P. O. Box 43844-00100 Nairobi Kenya., Shadrack DM; Department of Chemistry, Faculty of Natural and Applied Sciences, St. John's University of Tanzania P. O. Box 47 Dodoma Tanzania dmshadrack@gmail.com mshadrack@sjut.ac.tz.

Publikováno v: RSC advances [RSC Adv] 2021 Oct 07; Vol. 11 (52), pp. 33136-33147. Date of Electronic Publication: 2021 Oct 07 (Print Publication: 2021).

Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms.

Autor: Shadrack DM; Department of Health and Biomedical Sciences, School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, P.O.Box 447, Arusha, Tanzania; Department of Chemistry, Faculty of Natural and Applied Sciences, St John's University of Tanzania, P.O.Box 47, Dodoma, Tanzania. Electronic address: mshadrack@sjut.ac.tz., Deogratias G; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania; Department of Materials and Energy Science and Engineering, The Nelson Mandela African Institution of Science and Technology, P.O.Box 447, Arusha, Tanzania., Kiruri LW; Department of Chemistry, P.O.Box 43844-00100, Kenyatta University, Nairobi, Kenya., Swai HS; Department of Health and Biomedical Sciences, School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, P.O.Box 447, Arusha, Tanzania., Vianney JM; Department of Health and Biomedical Sciences, School of Life Science and Bioengineering, The Nelson Mandela African Institution of Science and Technology, P.O.Box 447, Arusha, Tanzania., Nyandoro SS; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania. Electronic address: nyandoro@udsm.ac.tz.

Publikováno v: Journal of molecular graphics & modelling [J Mol Graph Model] 2021 Jun; Vol. 105, pp. 107871. Date of Electronic Publication: 2021 Feb 23.

Environmentally persistent free radicals inhibit cytochrome P450 activity in rat liver microsomes.

Autor: Reed JR; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA; The Stanley S. Scott Cancer Center, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA. Electronic address: rreed@lsuhsc.edu., Cawley GF; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA; The Stanley S. Scott Cancer Center, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA., Ardoin TG; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA; The Stanley S. Scott Cancer Center, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA., Dellinger B; Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA., Lomnicki SM; Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA., Hasan F; Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA., Kiruri LW; Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA., Backes WL; Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA; The Stanley S. Scott Cancer Center, Louisiana State University Health Science Center, 533 Bolivar St., New Orleans, LA 70112, USA.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2014 Jun 01; Vol. 277 (2), pp. 200-9. Date of Electronic Publication: 2014 Apr 05.