Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Kirti, Kaul"'
1
Akademický článek
Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages
Autor: Dinesh K. Ahirwar, Bo Peng, Manish Charan, Swati Misri, Sanjay Mishra, Kirti Kaul, Salha Sassi, Venkat Sundar Gadepalli, Jalal Siddiqui, Wayne O. Miles, Ramesh K. Ganju
Publikováno v: Molecular Oncology, Vol 17, Iss 5, Pp 839-856 (2023)
Small‐cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with poor patient prognosis. However, the mechanisms that regulate SCLC progression and metastasis remain undefined. Here, we show that the expression of the slit
Externí odkaz: https://doaj.org/article/df0b9af7c6e34afcaeb6c86e0c2d65cd
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2
Akademický článek
cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment
Autor: Sanjay Mishra, Manish Charan, Rajni Kant Shukla, Pranay Agarwal, Swati Misri, Ajeet K. Verma, Dinesh K. Ahirwar, Jalal Siddiqui, Kirti Kaul, Neety Sahu, Kunj Vyas, Ayush Arpit Garg, Anum Khan, Wayne O. Miles, Jonathan W. Song, Nidhi Bhutani, Ramesh K. Ganju
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Molecular mechanisms underlying inflammation-associated breast tumor growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to enhance breast cancer growth and metastasis. However, the S100A7-mediated molecu
Externí odkaz: https://doaj.org/article/828bc8c8787a4e5b8a20e7cf1c6fef35
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3
Akademický článek
Slit2-Mediated Metabolic Reprogramming in Bone Marrow-Derived Macrophages Enhances Antitumor Immunity
Autor: Kirti Kaul, Martin Benej, Sanjay Mishra, Dinesh K. Ahirwar, Marshleen Yadav, Kristin I. Stanford, Naduparambil K. Jacob, Nicholas C. Denko, Ramesh K. Ganju
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Slit2 exerts antitumor effects in various cancers; however, the underlying mechanism, especially its role in regulating the immune, especially in the bone marrow niche, system is still unknown. Elucidating the behavior of macrophages in tumor progres
Externí odkaz: https://doaj.org/article/f0546ee5282a443ba0ef378ffa6dfd85
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4
cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment
Autor: Kunj Vyas, Anum Khan, Ajeet Kumar Verma, Dinesh K. Ahirwar, Jonathan W. Song, Jalal K. Siddiqui, Wayne O. Miles, Manish Charan, Ramesh K. Ganju, Nidhi Bhutani, Ayush Arpit Garg, Neety Sahu, Kirti Kaul, Pranay Agarwal, Swati Misri, Rajni Kant Shukla, Sanjay Mishra
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Background: Metastasis is the major cause of mortality in breast cancer; however, the molecular mechanisms remain elusive. In our previous study, we demonstrated that S100A7/RAGE mediates breast cancer growth and metastasis by recruitment of tumor-as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98538e44549605a5f0bbcd27cfc130a
https://doaj.org/article/828bc8c8787a4e5b8a20e7cf1c6fef35
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5
Directional Migration of Breast Cancer Cells Hindered by Induced Electric Fields May Be Due to Accompanying Alteration of Metabolic Activity
Autor: Ramesh K. Ganju, Ayush Arpit Garg, Jonathan W. Song, Vish V. Subramaniam, Travis H. Jones, Kirti Kaul
Publikováno v: Bioelectricity
Background: Induced electric fields (iEFs) control directional breast cancer cell migration. While the connection between migration and metabolism is appreciated in the context of cancer and metastasis, effects of iEFs on metabolic pathways especiall
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865296827fded188b91a31558941cc81
https://doi.org/10.1089/bioe.2020.0048
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6
Abstract PS17-28: Abrupt involution of lactating mammary gland induces metabolic reprogramming conducive to pro-tumorigenic changes
Autor: Bhuvaneswari Ramaswamy, Hee Kyung Kim, Ramesh K. Ganju, Neelam Shinde, Saba Mehra, Sarmila Majumder, Kirti Kaul, Resham Mawalkar, Allen Zhang
Publikováno v: Cancer Research. 81:PS17-28
Background: Epidemiological studies indicate that prolonged breast feeding reduces the risk of triple negative breast cancer (TNBC), which carries the worst prognosis. Prolonged breastfeeding allows gradual involution (GI) of the breast while lack of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33ae114969892882140b6f13d2074c50
https://doi.org/10.1158/1538-7445.sabcs20-ps17-28
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8
Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer
Autor: Ramesh K. Ganju, Sanjay Varikuti, Manish Charan, Nabanita Chatterjee, Swati Misri, Abhay R. Satoskar, Kirti Kaul, Dinesh K. Ahirwar, Sanjay Mishra, Subhadip Das
Publikováno v: Cell Death and Disease, Vol 11, Iss 9, Pp 1-15 (2020)
Cell Death & Disease
Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2 receptors, is a subtype of highly aggressive breast cancer with worse prognosis and poor survival rate. Macrophage migration inhibitory factor (MIF) is a pleiot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faa90a77c03ca20903af696036c75ce
http://link.springer.com/article/10.1038/s41419-020-02992-y
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9
Cannabidiol Inhibits Tumorigenesis in Cisplatin-Resistant Non-Small Cell Lung Cancer via TRPV2
Autor: Swati Misri, Kirti Kaul, Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Martin P. Barr, Dinesh K. Ahirwar, Ramesh K. Ganju
Publikováno v: Cancers; Volume 14; Issue 5; Pages: 1181
Chemotherapy forms the backbone of current treatments for many patients with advanced non-small-cell lung cancer (NSCLC). However, the survival rate is low in these patients due to the development of drug resistance, including cisplatin resistance. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48713fc96b1ef8cde1da687004801daa
https://pubmed.ncbi.nlm.nih.gov/35267489
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10
Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic mice
Autor: Michael Roden, C Wessel, Juan Arreguin-Cano, Alexander Strom, Kirti Kaul, Marie-Christine Simon, Michael Blaut, Volker Burkart, Anna Lena Reinbeck, Tomas Jelenik, Julia Heindirk, Fredrik Bäckhed
Publikováno v: J Biol Chem
Simon, M-C, Reinbeck, A L, Wessel, C, Heindirk, J, Jelenik, T, Kaul, K, Arreguin-Cano, J, Strom, A, Blaut, M, Backhed, F, Burkart, V & Roden, M 2020, ' Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic mice ', Journal of Biological Chemistry, vol. 295, no. 4, pp. 969-980 . https://doi.org/10.1074/jbc.RA119.010816
The rising prevalence of type 1 diabetes (T1D) over the past decades has been linked to lifestyle changes, but the underlying mechanisms are largely unknown. Recent findings point to gut-associated mechanisms in the control of T1D pathogenesis. In no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71fccdaa90947dd8821c0489e208981
https://doi.org/10.1074/jbc.ra119.010816
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