Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kirthana Prabhakar"'
Autor:
Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A. Boudreau, Ben Buelow, Karen Chang, Laura M. Davison, Suhasini Iyer, Vidyut Kalwit, Kristin Lewis Wilson, Harbani K. Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S. Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S. Ugamraj, Rodolfovan D. Yabut, Roland Buelow, Jocelyn Chapman, Nathan D. Trinklein, Katherine E. Harris
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The use of T-cell engagers (TCEs) to treat solid tumors is challenging, and several have been limited by narrow therapeutic windows due to substantial on-target, off-tumor toxicities due to the expression of low levels of target antigens on healthy t
Externí odkaz:
https://doaj.org/article/9e96f15bb0a54d7bb137adf3be604c3c
Autor:
Harbani K. Malik-Chaudhry, Kirthana Prabhakar, Harshad S. Ugamraj, Andrew A. Boudreau, Benjamin Buelow, Kevin Dang, Laura M. Davison, Katherine E. Harris, Brett Jorgensen, Heather Ogana, Duy Pham, Ute Schellenberger, Wim Van Schooten, Roland Buelow, Suhasini Iyer, Nathan D. Trinklein, Udaya S. Rangaswamy
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The therapeutic potential of targeting CD19 in B cell malignancies has garnered attention in the past decade, resulting in the introduction of novel immunotherapy agents. Encouraging clinical data have been reported for T cell-based targeting agents,
Externí odkaz:
https://doaj.org/article/54c6dadc1dc04e3c82d81639cfba9a39
Autor:
Vijayasaradhi Setaluri, Michelle E. Kimple, Jaclyn A. Wisinski, B. Jack Longley, Laura Block, Kirthana Prabhakar, Edgardo Castro-Pérez, Carlos I. Rodríguez
Cyclic AMP (cAMP) is an important second messenger that regulates a wide range of physiologic processes. In mammalian cutaneous melanocytes, cAMP-mediated signaling pathways activated by G-protein–coupled receptors (GPCR), like melanocortin 1 recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1434a8ad3e3cc041b61ea9c814ed8c22
https://doi.org/10.1158/1541-7786.c.6540133.v1
https://doi.org/10.1158/1541-7786.c.6540133.v1
Autor:
Vijayasaradhi Setaluri, Michelle E. Kimple, Jaclyn A. Wisinski, B. Jack Longley, Laura Block, Kirthana Prabhakar, Edgardo Castro-Pérez, Carlos I. Rodríguez
Fig. S1. Characterization of melanoma tumors and tumor derived cells of BrafCA/Pten-/- mouse. Fig. S2. Status of cAMP signaling in metastatic melanoma. Fig S3. Effect of cAMP inducing agent on human metastatic melanoma cell lines. Fig. S4. Survival o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1bd6b3f80fa34995dd6ab74fdbf899
https://doi.org/10.1158/1541-7786.22512109.v1
https://doi.org/10.1158/1541-7786.22512109.v1
Autor:
Dareen Mikheil, Kirthana Prabhakar, Tun Lee Ng, Sireesh Teertam, B. Jack Longley, Michael A. Newton, Vijayasaradhi Setaluri
Publikováno v:
Cancers; Volume 15; Issue 2; Pages: 519
Both oncogenic and tumor suppressor roles have been assigned to Notch signaling in melanoma. In clinical trials, Notch inhibitors proved to be ineffective for melanoma treatment. Notch signaling has also been implicated in melanoma transdifferentiati
Autor:
Dareen M. Mikheil, Ayyan Arshad, Kirthana Prabhakar, Michael A. Newton, Carlos I. Rodriguez, Vijayasaradhi Setaluri
Publikováno v:
Pigment Cell Melanoma Res
The role of Notch signaling in melanoma drug resistance is not well understood. In this study, we show that although NOTCH proteins are upregulated in metastatic melanoma cell lines, Notch signaling inhibition had no effect on cell survival, growth,
Autor:
Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein, Hannes Kehm, Aarti Balasubramani, Andrew A. Boudreau, Ben Buelow, Karen Chang, Laura M. Davison, Suhasini Iyer, Vidyut Kalwit, Harbani Malik-Chaudhry, Will Pierson, Geovanni Pineda, Udaya S. Rangaswamy, Sowmya Saiganesh, Ute Schellenberger, Harshad S. Ugamraj, Roland Buelow, Jocelyn Chapman, Nathan D. Trinklein, Katherine E. Harris
Publikováno v:
Cancer Research. 82:6244-6244
The use of T cell engagers (TCEs) to treat solid tumors in humans is challenging, and several have been limited by narrow therapeutic windows due to substantial toxicity. Dose-limiting toxicities of TCEs include cytokine release syndrome (CRS) and on
Autor:
Suhasini Iyer, Roland Buelow, Udaya Rangaswamy, Harbani K. Malik-Chaudhry, Kevin Dang, Katherine E. Harris, Duy Pham, Nathan D. Trinklein, Benjamin Buelow, Andrew Boudreau, Harshad Ugamraj, Brett Jorgensen, Wim Van Schooten, Heather Ogana, Laura Davison, Ute Schellenberger, Kirthana Prabhakar
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The therapeutic potential of targeting CD19 in B cell malignancies has garnered attention in the past decade, resulting in the introduction of novel immunotherapy agents. Encouraging clinical data have been reported for T cell-based targeting agents,
Autor:
Kirthana Prabhakar, Ranjan J. Perera, Vijayasaradhi Setaluri, Dareen M. Mikheil, Carlos I. Rodrίguez, Aishwarya Iyer Bhasker, Ashika Jayanthy
Publikováno v:
Mol Carcinog
Wnt/β-catenin signaling plays an important role in melanocyte biology, especially in the early stages of melanocyte transformation and melanomagenesis. β-catenin, encoded by the gene CTNNB1, is an intracellular signal transducer of Wnt signaling an
Autor:
Aarti Balasubramani, Ute Schellenberger, Harshad Ugamraj, Suhasini Iyer, Nathan D. Trinklein, Laura Davison, Brian Avanzino, Sharon Hartstein, Ben Buelow, Andrew Boudreau, Sowmya Saiganesh, Priya Ganesan, Duy Pham, Udaya Rangaswamy, Kirthana Prabhakar, Hannes Kehm, Harbani K. Malik-Chaudhry, Katherine E. Harris
Publikováno v:
Journal of Clinical Oncology. 38:e18050-e18050
e18050 Background: Ovarian Cancer (OvCa) is the leading cause of gynecologic cancer mortality in women. Since the introduction of platinum-based chemotherapy there has been little change in the prognosis of OvCa patients, with < 30% overall survival