Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kirsty S. Cullen"'
Autor:
Minna Honkanen-Scott, Kirsty S. Cullen, James Shaw, Merilin Georgiou, Penny E. Lovat, Catherine Arden, Vadivel Parthsarathy, Finbarr O'Harte, Stanislaus I Krishnanda, Francesco P Zummo
Publikováno v:
Autophagy. 18:799-815
Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4e206b7416dd3074c09c817ed6cb4d
https://doi.org/10.1080/15548627.2021.1956123
https://doi.org/10.1080/15548627.2021.1956123
Autor:
Francesco P, Zummo, Stanislaus I, Krishnanda, Merilin, Georgiou, Finbarr Pm, O'Harte, Vadivel, Parthsarathy, Kirsty S, Cullen, Minna, Honkanen-Scott, James Am, Shaw, Penny E, Lovat, Catherine, Arden
Publikováno v:
Autophagy. 18(4)
Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f229a223e01ba73fbfa6ebc847c0524
https://pubmed.ncbi.nlm.nih.gov/34338148
https://pubmed.ncbi.nlm.nih.gov/34338148
Autor:
Penny E. Lovat, Kirsty S. Cullen, Catherine Arden, James Shaw, Minna Honkanen-Scott, Francesco P Zummo
Publikováno v:
Diabetes. 66:1272-1285
Studies in animal models of type 2 diabetes have shown that glucagon-like peptide 1 (GLP-1) receptor agonists prevent β-cell loss. Whether GLP-1 mediates β-cell survival via the key lysosomal-mediated process of autophagy is unknown. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7392c048f457fe10417d0ec37aa0bf
https://doi.org/10.2337/db16-1009
https://doi.org/10.2337/db16-1009
Publikováno v:
Diabetic Medicine. 33:37-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a014cf76a34c34e4711a8aabb9316d6e
https://doi.org/10.1111/dme.2_13048
https://doi.org/10.1111/dme.2_13048
Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
Publikováno v:
Diabetes
OBJECTIVE The posttranslational regulation of glucokinase (GK) differs in hepatocytes and pancreatic β-cells. We tested the hypothesis that GK mutants that cause maturity-onset diabetes of the young (GK-MODY) show compromised activity and posttransl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c405d434c62ccdd0233ab9d647f888
https://doi.org/10.2337/db11-0423
https://doi.org/10.2337/db11-0423
Autor:
Ziad H. Al-Oanzi, Alex J. Lange, Howard C. Towle, Loranne Agius, Susan J. Tudhope, Catherine Arden, Kirsty S. Cullen, John L. Petrie
Publikováno v:
The Biochemical journal. 443(1)
Glucose metabolism in the liver activates the transcription of various genes encoding enzymes of glycolysis and lipogenesis and also G6pc (glucose-6-phosphatase). Allosteric mechanisms involving glucose 6-phosphate or xylulose 5-phosphate and covalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba60fbd5fcb0b73853a5ad33ae592f07
https://pubmed.ncbi.nlm.nih.gov/22214556
https://pubmed.ncbi.nlm.nih.gov/22214556
Publikováno v:
Diabetic Medicine. 30:4-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::136198e0cdea57fb85c451ec4663e88d
https://doi.org/10.1111/dme.12090_3
https://doi.org/10.1111/dme.12090_3