Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kirsty Rhian Greenow"'
Autor:
Lorenzo Melchor, Kirsty Rhian Greenow, Giusy Tornillo, James R. Bradford, Liliana D. Ordonez, Matthew J. Smalley, Howard Kendrick, Peter Giles
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727dcd5e54086c5702278edfcf890d39
https://orca.cardiff.ac.uk/id/eprint/140097/9/dmm048736.pdf
https://orca.cardiff.ac.uk/id/eprint/140097/9/dmm048736.pdf
Autor:
Howard Kendrick, Kirsty Rhian Greenow, Peter Giles, Lorenzo Melchor, Matthew J. Smalley, Giusy Tornillo, Liliana D. Ordonez, James R. Bradford
Understanding the mechanisms underlying tumour heterogeneity is key to development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes Brca1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76d47bcaef9aee05eaed390bb8438f37
https://doi.org/10.1101/2020.10.30.361998
https://doi.org/10.1101/2020.10.30.361998
Autor:
Nina Schmidt, Mara Campioni, Sarah Amir, Alan Richard Clarke, Kamilla Ripkens, Lee Parry, Michael Ehrmann, Christian Johannes, Alfonso Baldi, Kirsty Rhian Greenow, Vanda Lux, Masashi Kawaichi, Inga Irle, Chio Oka, Jasmin Nelles
Publikováno v:
BMC Cancer
Background Increased numbers and improperly positioned centrosomes, aneuploidy or polyploidy, and chromosomal instability are frequently observed characteristics of cancer cells. While some aspects of these events and the checkpoint mechanisms are we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f3264f168ba0870745238923d5cf79
https://orca.cardiff.ac.uk/id/eprint/92470/1/art%3A10.1186%2Fs12885-016-2425-8.pdf
https://orca.cardiff.ac.uk/id/eprint/92470/1/art%3A10.1186%2Fs12885-016-2425-8.pdf
Publikováno v:
Physiological Reviews. 92:75-99
Since the realization that embryonic stem cells are maintained in a pluripotent state through the interplay of a number of key signal transduction pathways, it is becoming increasingly clear that stemness and pluripotency are defined by the complex m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d757c5e01859675a994173b9e0b31e8
https://doi.org/10.1152/physrev.00040.2010
https://doi.org/10.1152/physrev.00040.2010
Publikováno v:
Cellular Signalling
Liver X receptors (LXRs) are ligand-dependent transcription factors that are activated by metabolites of cholesterol, oxysterols, and a number of synthetic agonists. LXRs play potent anti-atherogenic roles in part by stimulating the efflux of cholest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a6414318ed6a7c0a81c12d58cf005a
http://europepmc.org/articles/PMC3126994
http://europepmc.org/articles/PMC3126994
Publikováno v:
Current Protocols in Pharmacology
Breast cancer is a heterogeneous condition with no single standard of treatment and no definitive method for determining whether a tumor will respond to therapy. The development of murine models that faithfully mimic specific human breast cancer subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2155ddb3317f59a1290a1b4533a26e8
https://doi.org/10.1002/0471141755.ph1436s70
https://doi.org/10.1002/0471141755.ph1436s70
Autor:
Matthew J. Smalley, Howard Kendrick, José Palacios, Alan Mackay, Kirsty Rhian Greenow, María Ángeles López-García, Maria A. Atienza, Fiona-Ann Magnay, Jorge S. Reis-Filho, Lorenzo Melchor, Fernanda Milanezi, Gemma Molyneux, Daniel Nava-Rodrigues, David J. Robertson
The heterogeneous nature of mammary tumours may arise from different initiating genetic lesions occurring in distinct cells of origin. Here, we generated mice in which Brca2, Pten and p53 were depleted in either basal mammary epithelial cells or lumi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f6ee944105653fb3172c856e9553eb
https://orca.cardiff.ac.uk/id/eprint/58468/38/path.4345.pdf
https://orca.cardiff.ac.uk/id/eprint/58468/38/path.4345.pdf
Publikováno v:
Oncogene. 33(31)
Chk1 is essential in maintaining genomic stability due to its role in cell cycle regulation. Several recent studies have indicated that the abrogation of checkpoints in tumourigenesis through the inhibition of Chk1 may be of therapeutic value. To fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73e524948a3d639a489580ef09dd257
https://pubmed.ncbi.nlm.nih.gov/24037525
https://pubmed.ncbi.nlm.nih.gov/24037525
Autor:
Dipak Purshottam Ramji, Kirsty Rhian Greenow, Pelagia Foka, Sarah A. Rogers, N. N. Singh, S. Ali, S. Evans, Timothy R. Hughes, Scott Alexander Irvine, E. J. Harvey
Publikováno v:
Atherosclerosis Supplements. 5:29-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6853bf830b3a6a6692a1a20e5aa6aaff
https://doi.org/10.1016/s1567-5688(04)90128-1
https://doi.org/10.1016/s1567-5688(04)90128-1
Publikováno v:
Atherosclerosis Supplements. 5:25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7245202b80911632191efe34e4271928
https://doi.org/10.1016/s1567-5688(04)90110-4
https://doi.org/10.1016/s1567-5688(04)90110-4