Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kirsty McPherson"'
Autor:
Daniela Langenhorst, Tea Gogishvili, Eliana Ribechini, Susanne Kneitz, Kirsty McPherson, Manfred B Lutz, Thomas Hünig
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50080 (2012)
The ability of CD4(+)Foxp3(+) regulatory T-cells (Treg) to produce interleukin (IL)-10 is important for the limitation of inflammation at environmental interfaces like colon or lung. Under steady state conditions, however, few Tregs produce IL-10 ex
Externí odkaz:
https://doaj.org/article/f7a2af6b1c8f4353bd0e24cac9e33fbf
Publikováno v:
Vaccine. 37:2857-2863
The overwhelming increase of dengue virus (DENV) infections in recent years shows that current strategies to combat dengue do not work. The lack of a highly effective dengue vaccine and the limited effectivity of vector controls exacerbate this situa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dada37864ef109a8b39e09d5167501
https://doi.org/10.1016/j.vaccine.2019.03.062
https://doi.org/10.1016/j.vaccine.2019.03.062
Autor:
Jason M. Mackenzie, Nguyen Van Vinh Chau, Bridget Wills, Cameron P. Simmons, Paul R. Young, Kirsty McPherson, D.T. Hoai Tam
Publikováno v:
Vaccine. 33:7061-7068
This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177fb7c6fc446009296826ca25bfa1eb
https://doi.org/10.1016/j.vaccine.2015.09.103
https://doi.org/10.1016/j.vaccine.2015.09.103
Autor:
Klaus Okkenhaug, Tea Gogishvili, Fernando Elias, Kevin M. Dennehy, Thomas Hünig, Juliet L. Emery, Kirsty McPherson
Publikováno v:
European Journal of Immunology. 38:2528-2533
Almost all responses of naive T cells require co-stimulation, i.e. engagement of the clonotypic TCR with relevant antigen/MHC and the co-stimulatory molecule CD28. How CD28 contributes to T-cell proliferation remains poorly understood, with widely co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f811993a1b6a085522609e2379fa39
https://doi.org/10.1002/eji.200838223
https://doi.org/10.1002/eji.200838223
Publikováno v:
Critical Reviews in Clinical Laboratory Sciences. 42:71-104
The immune system must be tightly controlled not only to guarantee efficient protection from invading pathogens and oncogenic cells but also to avoid exaggerated immune responses and autoimmunity. This is achieved through interactions amongst leukocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e4648ec630011f35a85784cbb177cc
https://doi.org/10.1080/10408360590888983
https://doi.org/10.1080/10408360590888983
Autor:
Martin Leverkus, Dominikus Hausmann, Andreas Kerstan, Eva-Bettina Bröcker, Kirsty McPherson, Martin R. Sprick, Giorgio Stassi, Tina Wachter, Henning Walczak
Publikováno v:
Journal of Biological Chemistry. 279:52824-52834
Human keratinocytes undergo apoptosis following treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via surface-expressed TRAIL receptors 1 and 2. In addition, TRAIL triggers nonapoptotic signaling pathways including activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6906b711f1c7a87208345662c471ae
https://doi.org/10.1074/jbc.m409554200
https://doi.org/10.1074/jbc.m409554200
Publikováno v:
Microbiology Australia. 37:51
Dengue remains a major problem throughout the world with an estimated 30% of the world’s population at risk of infection. In the past few years, major advances have been made across virology, clinical insights, vaccines and mosquito control strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20993bced2b2d2f64155b558a2bc7b2e
https://doi.org/10.1071/ma16017
https://doi.org/10.1071/ma16017
Autor:
Jeremy P.C. Steele, Thomas Powles, Sarah Slater, Robin M. Rudd, Jonathan Shamash, Michael T. Sheaff, Kirsty McPherson, Paula Wells, Dean A. Fennell, Justin Stebbing
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 63(1)
Malignant pleural mesothelioma (MPM) is a rapidly progressive invariably lethal tumor. Treatment options remain limited and the outcome in relapsed disease is poor warranting new therapeutic options. Following our previous experience in the first-lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd70f75827ab7f33278c46b4ebb7c70
https://pubmed.ncbi.nlm.nih.gov/18486273
https://pubmed.ncbi.nlm.nih.gov/18486273
Autor:
Holger M. Reichardt, Denise Tischner, Kirsty McPherson, Jens van den Brandt, Stefan Wiehr, Katrien L. de Graaf, Fred Lühder, Robert Weissert, Ralf Gold, Thomas Herrmann
Publikováno v:
The American journal of pathology. 170(3)
To study the effect of enhanced glucocorticoid signaling on T cells, we generated transgenic rats overexpressing a mutant glucocorticoid receptor with increased ligand affinity in the thymus. We found that this caused massive thymocyte apoptosis at p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aadb2d52d6b37b90c0bdcda087aaf5
https://pubmed.ncbi.nlm.nih.gov/17322387
https://pubmed.ncbi.nlm.nih.gov/17322387
Autor:
Andreas Zettl, Hans Konrad Müller-Hermelink, Holger M. Reichardt, Jens van den Brandt, Kirsty McPherson, Soon-Hwan Kwon, Suzana Petrovic
Publikováno v:
European journal of immunology. 36(8)
Dysregulated Notch signaling accounts for the majority of acute T lymphoblastic leukemia/lymphoma (T-ALL) cases in humans. Here, we characterize lymphomas from Notch1IC transgenic rats, which develop T-ALL shortly after weaning, and show that they di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f26edc3f9528d1a8c91d58ac7cdda8
https://pubmed.ncbi.nlm.nih.gov/16838279
https://pubmed.ncbi.nlm.nih.gov/16838279