Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kirsty MacLellan"'
Autor:
Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J. Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract SARS-CoV-2 exhibits a diverse host species range with variable outcomes, enabling differential host susceptibility studies to assess suitability for pre-clinical countermeasure and pathogenesis studies. Baseline virological, molecular and pa
Externí odkaz:
https://doaj.org/article/0bdbc34a3c9f4aa9acf1c9f0c03b6ceb
Autor:
Chrysi Sergaki, Saba Anwar, Martin Fritzsche, Ryan Mate, Robert J. Francis, Kirsty MacLellan-Gibson, Alastair Logan, Gregory C. A. Amos
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Background Effective standardisation of the microbiome field is essential to facilitate global translational research and increase the reproducibility of microbiome studies. In this study, we describe the development and validation of a whol
Externí odkaz:
https://doaj.org/article/d452701d9aba420d9e94cfa3496b2ad2
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Formulation is critical to successful delivery of lyophilized biologics. We have compared the impact of buffer choice and the addition of sodium chloride (a formulant often viewed as unfavorable for freeze-drying applications) on the outcome of trial
Externí odkaz:
https://doaj.org/article/8d8d195e3dfe464c8de0c0eb5b3c7dcb
Autor:
Robert J. Francis, Gillian Robb, Lee McCann, Bhagwati Khatri, James Keeble, Belinda Dagg, Brad Amos, Francisco J. Salguero, Mei Mei Ho, Anwen Bullen, Gail McConnell, Kirsty MacLellan-Gibson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Tuberculosis (TB) preclinical testing relies on in vivo models including the mouse aerosol challenge model. The only method of determining colony morphometrics of TB infection in a tissue in situ is two-dimensional (2D) histopathology. 2D me
Externí odkaz:
https://doaj.org/article/c753bc9f75174c4195e6c28918b47a23
Autor:
Leila Mekkaoui, Farhaan Parekh, Ekaterini Kotsopoulou, David Darling, Glenda Dickson, Gordon W. Cheung, Lucas Chan, Kirsty MacLellan-Gibson, Giada Mattiuzzo, Farzin Farzaneh, Yasuhiro. Takeuchi, Martin Pule
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 155-165 (2018)
Lentiviral vectors (LVs) have recently witnessed an increasing demand in research and clinical applications. Their current purification processes represent the main bottleneck in their widespread use, as the methods used are cumbersome and yield low
Externí odkaz:
https://doaj.org/article/fa0e0c7804034ed983ca5258b74e7dce
Autor:
Giada Mattiuzzo, James Ashall, Kathryn S Doris, Kirsty MacLellan-Gibson, Carolyn Nicolson, Dianna E Wilkinson, Ruth Harvey, Neil Almond, Robert Anderson, Stacey Efstathiou, Philip D Minor, Mark Page
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142751 (2015)
The 2013-present Ebola virus outbreak in Western Africa has prompted the production of many diagnostic assays, mostly based on nucleic acid amplification technologies (NAT). The calibration and performance assessment of established assays and those u
Externí odkaz:
https://doaj.org/article/efcff35a8d694740a5cd3c51e4f3d362
Autor:
Alessandro Costa, Ludovic Renault, Paolo Swuec, Tatjana Petojevic, James J Pesavento, Ivar Ilves, Kirsty MacLellan-Gibson, Roland A Fleck, Michael R Botchan, James M Berger
Publikováno v:
eLife, Vol 3 (2014)
The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear. Using electron microscopy, we have determined the structure of the CMG in the presence o
Externí odkaz:
https://doaj.org/article/1c9a75ab3cf549beafe69c123e444555
Autor:
Robert J. Francis, Deborah Ferguson, Sarah Kempster, Joanna Hall, Neil Berry, Kirsty MacLellan-Gibson
Publikováno v:
Histochemistry and Cell Biology. 158:383-388
Eosin Y is a common stain in histology. Although usually used for colourimetric imaging where the dye is used to stain pink/red a range of structures in the tissue, Eosin Y is also a fluorochrome, and has been used in this manner for decades. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a898ccf2072ebf8ff6a44c8b5822b8da
https://doi.org/10.1007/s00418-022-02130-z
https://doi.org/10.1007/s00418-022-02130-z
Autor:
Anwen Bullen, David J. Scurr, Paul Williams, Kim R. Hardie, Kirsty MacLellan-Gibson, James Brown, Morgan R. Alexander, Junting Zhang, Paulina D. Rakowska, Ian S. Gilmore
Publikováno v:
Analytical Chemistry. 92:9008-9015
Secondary ion mass spectrometry (SIMS) is gaining popularity for molecular imaging in the life sciences because it is label-free and allows imaging in two and three dimensions. The recent introduction of the OrbiSIMS has significantly improved the ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbeee66feb970a57579272e749f7afbb
https://doi.org/10.1021/acs.analchem.0c01125
https://doi.org/10.1021/acs.analchem.0c01125
Autor:
Chrysi Sergaki, Saba Anwar, Martin Fritzsche, Ryan Mate, Robert J. Francis, Kirsty MacLellan-Gibson, Alastair Logan, Gregory C. A. Amos
Publikováno v:
Microbiome. 10(1)
Background Effective standardisation of the microbiome field is essential to facilitate global translational research and increase the reproducibility of microbiome studies. In this study, we describe the development and validation of a whole cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efb476bfe806995a0583b1e031254b0
https://pubmed.ncbi.nlm.nih.gov/35945640
https://pubmed.ncbi.nlm.nih.gov/35945640