Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kirsty M. Mair"'
Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Obesity is a prevalent global public health issue characterized by excess body fat. Adipose tissue is now recognized as an important endocrine organ releasing an abundance of bioactive adipokines including, but not limited to, leptin, adiponectin and
Externí odkaz:
https://doaj.org/article/e707a74b117e4b268d08481bf3564675
Publikováno v:
Clinics in chest medicine. 42(1)
Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f7a9a8446bc5ab65b24657d1440206
https://pubmed.ncbi.nlm.nih.gov/33541615
https://pubmed.ncbi.nlm.nih.gov/33541615
Publikováno v:
C50. THE PERFECT DRUG: EXPERIMENTAL TREATMENTS OF PAH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6454ea7eddb12a387a7397ef40de5a85
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5059
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5059
Autor:
Kirsty M, Mair, Katie Y, Harvey, Alasdair D, Henry, Dianne Z, Hillyard, Margaret, Nilsen, Margaret R, MacLean
Publikováno v:
The European Respiratory Journal
Obesity is a common comorbidity for pulmonary arterial hypertension (PAH). Additionally, oestrogen and its metabolites are risk factors for the development of PAH. Visceral adipose tissue (VAT) is a major site of oestrogen production; however, the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5975ce8b717d254b13c336a1c1c2e0b
https://pubmed.ncbi.nlm.nih.gov/30923189
https://pubmed.ncbi.nlm.nih.gov/30923189
Autor:
Craig K. Docherty, Kirsty M. Mair, Nina Denver, Margaret R. MacLean, Sinead Griffin, Katie Y. Harvey
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319779317
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by increased pulmonary vascular resistance and pulmonary artery remodelling as result of increased vascular tone and vascular cell proliferation, respectively. Eventually, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42375ff0dc04c1c2653a6cc103a13aa4
https://eprints.gla.ac.uk/166663/1/166663.pdf
https://eprints.gla.ac.uk/166663/1/166663.pdf
Autor:
Craig K, Docherty, Katie Yates, Harvey, Kirsty M, Mair, Sinead, Griffin, Nina, Denver, Margaret R, MacLean
Publikováno v:
Advances in experimental medicine and biology. 1065
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by increased pulmonary vascular resistance and pulmonary artery remodelling as result of increased vascular tone and vascular cell proliferation, respectively. Eventually, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1781787d4d4318a0c472f565aaf5c821
https://pubmed.ncbi.nlm.nih.gov/30051404
https://pubmed.ncbi.nlm.nih.gov/30051404
Autor:
Margaret R. MacLean, Nicholas W. Morrell, Margaret Nilsen, Andrew H. Baker, Xudong D. Yang, Hannah Stevens, Emma Wallace, Kirsty M. Mair, Lynn Loughlin, Lu Long
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 191:1432-1442
Rationale: Females are predisposed to pulmonary arterial hypertension (PAH); evidence suggests that serotonin, mutations in the bone morphogenetic protein receptor (BMPR) II gene, and estrogens influence development of PAH. The 5-hydroxytryptamine 1B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3828c32bcae0d610de091d1fec8faa68
https://doi.org/10.1164/rccm.201412-2148oc
https://doi.org/10.1164/rccm.201412-2148oc
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 29:7-14
The calgranulin-like protein MTS1/S100A4 and the receptor for advanced glycation end-products (RAGE) have recently been implicated in mediating pulmonary arterial smooth muscle cell proliferation and vascular remodelling in experimental pulmonary art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a50e91750e95cf985503412b383f68b
https://doi.org/10.1016/j.pupt.2014.01.002
https://doi.org/10.1016/j.pupt.2014.01.002
Autor:
David J. Rowlands, Lynn Loughlin, Martin Hussey, Sonia Roberts, Audrey F. Wright, Matthew Thomas, Kirsty M. Mair, Nicholas Duggan, Margaret Nilsen, Josephine Fullerton, Margaret R. MacLean
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 190:456-467
Rationale: The incidence of pulmonary arterial hypertension is greater in women, suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males, exogenously administered estrogen can protect against pulmonary hypertension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0e047910ab884f06f992b47ad414f4
https://doi.org/10.1164/rccm.201403-0483oc
https://doi.org/10.1164/rccm.201403-0483oc
Autor:
Katie Y, Hood, Kirsty M, Mair, Adam P, Harvey, Augusto C, Montezano, Rhian M, Touyz, Margaret R, MacLean
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective— Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hy
Objective— Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3616bacd847e8ea2a051b81d30ca260c
https://pubmed.ncbi.nlm.nih.gov/28473438
https://pubmed.ncbi.nlm.nih.gov/28473438