Zobrazeno 1 - 4
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pro vyhledávání: '"Kirsty M Ferguson"'
Autor:
Kirsty M. Ferguson, Carla Blin, Neza Alfazema, Ester Gangoso, Steven M. Pollard, Maria Angeles Marques-Torrejon
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Patients with glioblastoma (GBM) face a dismal prognosis. GBMs are driven by glioblastoma stem cells (GSCs) that display a neural stem cell (NSC)-like phenotype. These glioblastoma stem cells are often in a quiescent state that evades current therapi
Externí odkaz:
https://doaj.org/article/b893e2610e004190abc228f646833465
Autor:
Kirsty M Ferguson, Carla Blin, Claudia Garcia-Diaz, Harry Bulstrode, Raul Bardini Bressan, Katrina McCarten, Steven M. Pollard
SummaryThe molecular mechanisms controlling the balance of quiescence and proliferation in adult neural stem cells (NSCs) are often deregulated in brain cancers such as glioblastoma (GBM). Previously, we reported that FOXG1, a forebrain-restricted ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bfcf3e2fa0739d8d82d415d60ec17f0
https://doi.org/10.1101/2022.06.30.498283
https://doi.org/10.1101/2022.06.30.498283
Autor:
Simon R. Tomlinson, Kirsty M. Ferguson, Charles A. C. Williams, Richard A. Anderson, Neza Alfazema, Leanne Bradley, Benjamin Southgate, Alex von Kriegsheim, Maria Angeles Marques-Torrejon, Faye L Robertson, Gillian Morrison, Vivien Grant, Steven M. Pollard, Carla Blin, Jimi Wills, James Ashmore, Raul Bardini Bressan
Publikováno v:
Bressan, R B, Southgate, B, Ferguson, K M, Blin, C, Grant, V, Alfazema, N, Wills, J C, Marques, M A, Morrison, G M, Ashmore, J, Robertson, F, Williams, C A C, Bradley, L, von Kriegsheim, A, Anderson, R A, Tomlinson, S R & Pollard, S M 2021, ' Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants ', Cell Stem Cell, vol. 28, no. 5, pp. 877-893.e9 . https://doi.org/10.1016/j.stem.2021.01.016
Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b62ac005e0806ba597ff012910e68b7
https://www.pure.ed.ac.uk/ws/files/253710541/mmc4.pdf
https://www.pure.ed.ac.uk/ws/files/253710541/mmc4.pdf
Autor:
Sabine Gogolok, Duncan Sproul, Kirsty M. Ferguson, Sladjana Gagrica, Steven M. Pollard, Harry Bulstrode, Vassiliki Fotaki, Raul Bardini Bressan, Vivien Grant, Paul Bertone, Ewan Johnstone, Maria Angeles Marques-Torrejon, Christine Ender, Ester Gangoso, Carla Blin
Publikováno v:
Bulstrode, H, Johnstone, E, Marques-Torrejon, M A, Ferguson, K M, Bressan, R B, Blin, C, Grant, V, Gogolok, S, Gangoso, E, Gagrica, S, Ender, C, Fotaki, V, Sproul, D, Bertone, P & Pollard, S M 2017, ' Elevated FOXG 1 and SOX 2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators ', Genes and Development, vol. 31, no. 8, pp. 757-773 . https://doi.org/10.1101/gad.293027.116
Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2374d5a377031870a29e641cf6216c60
https://hdl.handle.net/20.500.11820/db1c7660-9d59-4244-a3be-2ba3d65836e3
https://hdl.handle.net/20.500.11820/db1c7660-9d59-4244-a3be-2ba3d65836e3