Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Kirsty L Spalding"'
Autor:
Asael Lubotzky, Ilana Pelov, Ronen Teplitz, Daniel Neiman, Adama Smadja, Hai Zemmour, Sheina Piyanzin, Bracha-Lea Ochana, Kirsty L Spalding, Benjamin Glaser, Ruth Shemer, Yuval Dor, Yoav Kohn
Publikováno v:
eLife, Vol 11 (2022)
Schizophrenia is a common, severe, and debilitating psychiatric disorder. Despite extensive research there is as yet no biological marker that can aid in its diagnosis and course prediction. This precludes early detection and intervention. Imaging st
Externí odkaz:
https://doaj.org/article/99c557cbe6234e8c8dd6f08840d16183
Autor:
Kanar Alkass, Hisako Saitoh, Bruce A Buchholz, Samuel Bernard, Gunilla Holmlund, David R Senn, Kirsty L Spalding, Henrik Druid
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69597 (2013)
The characterization of unidentified bodies or suspected human remains is a frequent and important task for forensic investigators. However, any identification method requires clues to the person's identity to allow for comparisons with missing perso
Externí odkaz:
https://doaj.org/article/38b8ddbdbe63428f8074866ae8809ee3
Autor:
Qian Li, Kirsty L. Spalding
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Adipocytes can increase in volume up to a thousand-fold, storing excess calories as triacylglycerol in large lipid droplets. The dramatic morphological changes required of adipocytes demands extensive cytoskeletal remodeling, including lipid droplet
Externí odkaz:
https://doaj.org/article/a299a9ae53844857a03174d9dabd4ebb
Autor:
Qian Li, Kirsty L. Spalding
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104105- (2022)
Externí odkaz:
https://doaj.org/article/6a150e0d8b4047069f500890b7e46c05
Autor:
Asael Lubotzky, Hai Zemmour, Daniel Neiman, Marc Gotkine, Netanel Loyfer, Sheina Piyanzin, Bracha-Lea Ochana, Roni Lehmann-Werman, Daniel Cohen, Joshua Moss, Judith Magenheim, Maureen F. Loftus, Lauren Brais, Kimmie Ng, Raul Mostoslavsky, Brian M. Wolpin, Aviad Zick, Myriam Maoz, Albert Grinshpun, Anatoli Kustanovich, Chen Makranz, Jonathan E. Cohen, Tamar Peretz, Ayala Hubert, Mark Temper, Azzam Salah, Shani Avniel-Polak, Simona Grozinsky-Glasberg, Kirsty L. Spalding, Ariel Rokach, Tommy Kaplan, Benjamin Glaser, Ruth Shemer, Yuval Dor
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Cancer inflicts damage to surrounding normal tissues, which can culminate in fatal organ failure. Here, we demonstrate that cell death in organs affected by cancer can be detected by tissue-specific methylation patterns of circulating cell-free DNA (
Externí odkaz:
https://doaj.org/article/1f735d48364b40a883ef532ff63dc0fb
Autor:
Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and
Externí odkaz:
https://doaj.org/article/841a0167145749b69b07423fda860202
Autor:
Kirsty L. Spalding, Samuel Bernard, Erik Näslund, Mehran Salehpour, Göran Possnert, Lena Appelsved, Keng-Yeh Fu, Kanar Alkass, Henrik Druid, Anders Thorell, Mikael Rydén, Peter Arner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Lipid turnover in tissues can be calculated from ratios of different carbon isotopes. Here the authors use this approach to study lipid turnover in two distinct adipose tissue depots and find that, in obese individuals, visceral fat is more lipolytic
Externí odkaz:
https://doaj.org/article/b650818ee3aa43a0a056c56d449a3dbc
Autor:
Matthew J. Harms, Qian Li, Sunjae Lee, Cheng Zhang, Bengt Kull, Stefan Hallen, Anders Thorell, Ida Alexandersson, Carolina E. Hagberg, Xiao-Rong Peng, Adil Mardinoglu, Kirsty L. Spalding, Jeremie Boucher
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 213-225.e5 (2019)
Summary: White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes. We describe a method for the culture of mature white adipocytes under a permeabl
Externí odkaz:
https://doaj.org/article/d72acb327cce4a36b182a5b30c145d83
Autor:
Paul Petrus, Niklas Mejhert, Patricia Corrales, Simon Lecoutre, Qian Li, Estela Maldonado, Agne Kulyté, Yamila Lopez, Mark Campbell, Juan R. Acosta, Jurga Laurencikiene, Iyadh Douagi, Hui Gao, Concepción Martínez-Álvarez, Per Hedén, Kirsty L. Spalding, Antonio Vidal-Puig, Gema Medina-Gomez, Peter Arner, Mikael Rydén
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 551-560.e5 (2018)
Summary: White adipose tissue (WAT) mass is determined by adipocyte size and number. While adipocytes are continuously turned over, the mechanisms controlling fat cell number in WAT upon weight changes are unclear. Herein, prospective studies of huma
Externí odkaz:
https://doaj.org/article/9419d552f02b4179bebb20837d864c38
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity
Autor:
Carolina E. Hagberg, Qian Li, Maria Kutschke, Debajit Bhowmick, Endre Kiss, Irina G. Shabalina, Matthew J. Harms, Olga Shilkova, Viviana Kozina, Jan Nedergaard, Jeremie Boucher, Anders Thorell, Kirsty L. Spalding
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2746-2756.e5 (2018)
Summary: Adipocytes, once considered simple lipid-storing cells, are rapidly emerging as complex cells with many biologically diverse functions. A powerful high-throughput method for analyzing single cells is flow cytometry. Several groups have attem
Externí odkaz:
https://doaj.org/article/dedbec0eb51f44e3b6ff06acbc581ec7