Výsledky vyhledávání - "Kirsty Flower"

Akademický článek

Loci-specific differences in blood DNA methylation in HBV-negative populations at risk for hepatocellular carcinoma development

Autor: Katarzyna Lubecka, Kirsty Flower, Megan Beetch, Jay Qiu, Lucinda Kurzava, Hannah Buvala, Adam Ruhayel, Samer Gawrieh, Suthat Liangpunsakul, Tracy Gonzalez, George McCabe, Naga Chalasani, James M Flanagan, Barbara Stefanska

Publikováno v: Epigenetics, Vol 13, Iss 6, Pp 605-626 (2018)

Late onset of clinical symptoms in hepatocellular carcinoma (HCC) results in late diagnosis and poor disease outcome. Approximately 85% of individuals with HCC have underlying liver cirrhosis. However, not all cirrhotic patients develop cancer. Relia

Externí odkaz: https://doaj.org/article/c5bfb836f061428f86dac7597ef42f67

Zobrazit plný text záznamu

Akademický článek

Epigenetic control of viral life-cycle by a DNA-methylation dependent transcription factor.

Autor: Kirsty Flower, David Thomas, James Heather, Sharada Ramasubramanyan, Susan Jones, Alison J Sinclair

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25922 (2011)

Epstein-Barr virus (EBV) encoded transcription factor Zta (BZLF1, ZEBRA, EB1) is the prototype of a class of transcription factor (including C/EBPalpha) that interact with CpG-containing DNA response elements in a methylation-dependent manner. The EB

Externí odkaz: https://doaj.org/article/21ccba172c904c5889266216e62085a7

Zobrazit plný text záznamu

Akademický článek

Evaluation of a prediction protocol to identify potential targets of epigenetic reprogramming by the cancer associated Epstein Barr virus.

Autor: Kirsty Flower, Elizabeth Hellen, Melanie J Newport, Susan Jones, Alison J Sinclair

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9443 (2010)

Epstein Barr virus (EBV) infects the majority of the human population, causing fatal diseases in a small proportion in conjunction with environmental factors. Following primary infection, EBV remains latent in the memory B cell population for life. R

Externí odkaz: https://doaj.org/article/9faff517e410496abb379e8a5302f307

Zobrazit plný text záznamu

Supplementary Figures S1-S11 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Supplementary Figure S1: Clinical Study Schematic. Supplementary Figure S2: Significant changes in blood DNA methylation at time of ovarian cancer relapse compared to at presentation. Supplementary Figure S3: Methylation profiles of blood DNA at time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2c3d8cb8d3bc622340577f0aef3c7c
https://doi.org/10.1158/1078-0432.22463772.v1

Zobrazit plný text záznamu

Supplementary Table 4 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Supplementary Table S4 - Summary Statistics for 8 CpG sites and Annotation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60511358bf9f463c512c8e9fab39a5c
https://doi.org/10.1158/1078-0432.22463760

Zobrazit plný text záznamu

Data from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Purpose: DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c46eabc66e9f93bbc183962695a5b3d
https://doi.org/10.1158/1078-0432.c.6525510.v1

Zobrazit plný text záznamu

Supplementary Table 3 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Supplementary Table S3 - Cox Proportional Hazards Regression models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c54e4ed383c604e35f0de15302e8f32
https://doi.org/10.1158/1078-0432.22463763.v1

Zobrazit plný text záznamu

Supplementary Table 1 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Supplementary Table S1 - Patient Characteristics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011f44a3ebe594d6fbb81f518e24eecc
https://doi.org/10.1158/1078-0432.22463769.v1

Zobrazit plný text záznamu

Supplementary Table 2 from Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

Supplementary Table S2 - Pyrosequencing Primers used in this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e9d9285f321e03f5855cd07b5e936f
https://doi.org/10.1158/1078-0432.22463766.v1

Zobrazit plný text záznamu

Is there a Role for Epigenetic Enhancement of Immunomodulatory Approaches to Cancer Treatment?

Autor: Sadaf Ghaem-Maghami, Robert S. Brown, Kirsty Flower

Publikováno v: Current Cancer Drug Targets. 18:5-15

The efficacy of cancer immunotherapy relies on the ability of the host immune system to recognise the cancer as non-self and eliminate it from the body. Whilst this is an extremely fertile area of medical research, with positive clinical trials showi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e439bce85205c45f3ef4772a50f66f0
https://doi.org/10.2174/1568009617666170206105131

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání