Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kirsty E. Waddington"'
Autor:
Alexandra E. Oppong, Leda Coelewij, Georgia Robertson, Lucia Martin-Gutierrez, Kirsty E. Waddington, Pierre Dönnes, Petra Nytrova, Rachel Farrell, Inés Pineda-Torra, Elizabeth C. Jury
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109225- (2024)
Summary: There are no blood-based biomarkers distinguishing patients with relapsing-remitting (RRMS) from secondary progressive multiple sclerosis (SPMS) although evidence supports metabolomic changes according to MS disease severity. Here machine le
Externí odkaz:
https://doaj.org/article/71777b4f62664398a66e0208bc11171f
Autor:
Inés Pineda-Torra, Sherrice Siddique, Kirsty E. Waddington, Rachel Farrell, Elizabeth C. Jury
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination and subsequent degeneration. Systemic lipid metabolism is disturbed in people with MS, and
Externí odkaz:
https://doaj.org/article/0eb244855f074c519c9fd694f2135b05
Autor:
Kirsty E. Waddington, Artemis Papadaki, Leda Coelewij, Marsilio Adriani, Petra Nytrova, Eva Kubala Havrdova, Anna Fogdell-Hahn, Rachel Farrell, Pierre Dönnes, Inés Pineda-Torra, Elizabeth C. Jury
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: Neutralizing anti-drug antibodies (ADA) can greatly reduce the efficacy of biopharmaceuticals used to treat patients with multiple sclerosis (MS). However, the biological factors pre-disposing an individual to develop ADA are poorly chara
Externí odkaz:
https://doaj.org/article/3f18697f0ea04704bfe363826743d56e
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation and function. Moreover, changes in PM lipid composition affect th
Externí odkaz:
https://doaj.org/article/f55622cfd3974a298d29c167b545187a
Autor:
Andrew Nicolaides, Filipa Farinha, Ines Pineda-Torra, Edward J. Smith, Elvira Chocano, Kirsty E Waddington, Sara Croca, Leda Coelewij, Thomas McDonnell, Elizabeth C. Jury, Jyoti Bakshi, George Robinson, Maura Griffin, Pierre Dönnes, Anisur Rahman, Junjie Peng
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing cardiovascular disease. Standard serum lipid measurements in clinical practice do not predict cardiovascular disease risk in patients with SLE. More deta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee8bf26d3e158b38f42e2e543766912
https://pubmed.ncbi.nlm.nih.gov/33535791
https://pubmed.ncbi.nlm.nih.gov/33535791
Autor:
Sara Andreone, Lucia Martin-Gutierrez, Eden Chrifi-Alaoui, Beatriz Rubio-Cuesta, Kirsty E Waddington, Iveta Ivanova, Dylan M. Owen, Kok-Siong Poon, George Robinson, Ines Pineda-Torra, Elizabeth C. Jury
Publikováno v:
Proc Natl Acad Sci U S A
The liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including lipid metabolism, is a crucial step in T cell activation. Here, we explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7cecb4789bb4631d3374837d63de09
http://hdl.handle.net/11573/1549837
http://hdl.handle.net/11573/1549837
Autor:
Kirsty E Waddington, NL Thompson, Vivek Gupta, Meena Naja, Nyarko Ahwireng, Lucia Martin-Gutierrez, Akash Gandhi, David A. Isenberg, Hannah Peckham, Giulia Varnier, Elizabeth C. Jury, Hajar J'bari, George Robinson, Junjie Peng, Coziana Ciurtin, R Radmore, Claire M. Bradford, Wing-Han Wu
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)References. 73(9)
OBJECTIVE Similarities in the clinical and laboratory features of primary Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE) have led to attempts to treat patients with primary SS or SLE with similar biologic therapeutics. However, the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85acb178ef08ac77f068907286ceba5a
https://pubmed.ncbi.nlm.nih.gov/33645922
https://pubmed.ncbi.nlm.nih.gov/33645922
Autor:
Michael Brown, George Robinson, Ellie Hawkins, Christopher J A Duncan, Hannah Peckham, Kirsty E Waddington, Aidan T Hanrath, Michael Marks, Mandy Greenwood, Christopher Adeney, Emon Khan, Rachel Tattersall, B. Clare Lendrem, Joe West, Puja Mehta, Trevor Liddle, Hajar J'bari, Meena Naja, Eve McLoughlin, Colin J Crooks, Ina Schim van der Loeff, Elizabeth C. Jury, Antonia Snell, Kenneth F Baker, Tommy Rampling, Jessica J Manson, Junjie Peng, Amanda Ledlie, Akish Luintel, Liliana R Santos, Anthony De Soyza, Matthew Collin, Lucia Martin-Gutierrez, Mervyn Singer, Bethan Goulden, Bryan Williams
Publikováno v:
The Lancet Rheumatology
Summary Background A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0391d747b83a76a08cb7d663678c43
Autor:
Elvira Chocano, Junjie Peng, Filipa Farinha, Andrew Nicolaides, Anisur Rahman, Kirsty E Waddington, Edward J. Smith, Ines Pineda-Torra, George Robinson, Thomas McDonnell, Sara Croca, Maura Griffin, Pierre Dönnes, Elizabeth C. Jury, Leda Coelewij
BackgroundPatients with systemic lupus erythematosus (SLE) have an increased risk of developing cardiovascular disease (CVD) and 30-40% have sub-clinical atherosclerosis on vascular ultrasound scanning. Standard measurements of serum lipids in clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96ba0b233b4899769f42c16bb1ce348
https://doi.org/10.1101/2020.08.11.20172536
https://doi.org/10.1101/2020.08.11.20172536
Autor:
Kirsty E Waddington, Christine A. Orengo, George Robinson, Elvira Chocano, Laurel Woodridge, Paul Ashford, Ines Pineda Torra, Elizabeth C. Jury, Anisur Rahman
Women with Systemic Lupus Erythematosus (SLE) show significantly increased cardiovascular risk compared to the general population. However, despite CVD being a major cause of morbidity and mortality for these women, this increased risk is not managed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0329de04f652343a8c2c18db2eabb33
https://doi.org/10.1101/2020.08.05.20169136
https://doi.org/10.1101/2020.08.05.20169136