Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kirstin Winkler"'
Autor:
Falk R. Wiedemann, Elmar Kirches, Claus-W. Wallesch, C. Mawrin, Kirstin Winkler-Stuck, Wolfram S. Kunz, Hartmut Lins, Knut Dietzmann
Publikováno v:
Journal of Neural Transmission. 112:499-518
The origin and tissue distribution of the mitochondrial dysfunction in Parkinson's disease (PD) remains still a matter of controversy. To re-evaluate a probably free radical-born, generalized mitochondrial impairment in PD, we applied optimized enzym
Publikováno v:
Journal of the Neurological Sciences. 220:41-48
Several lines of evidence suggest an impairment of mitochondrial function in the brain of patients with Parkinson's disease (PD). However, the presence of a detectable mitochondrial defect in extracerebral tissue of these patients remains a matter of
Autor:
Klaus Ender, Hans Steinhart, Gerd Nuernberg, Kirstin Winkler, Stephanie Lorenz, Karin Nuernberg, Rainer Rickert
Publikováno v:
European Journal of Lipid Science and Technology. 104:463-471
The objective of the experiment with cattle was to produce high quality beef under different feeding conditions and to increase the concentration of essential fatty acids in muscle. In total 10 German Simmental (GS) bulls and 9 German Holstein (GH) s
Autor:
Kirstin Winkler, Hans Steinhart
Publikováno v:
Journal of Separation Science. 24:663-668
A method has been developed for the separation and identification of conjugated fatty acid isomers as distinct from conjugated linoleic acid (CLA). Cheese fat was extracted using n-hexane and converted into fatty acid methyl esters (FAMEs) with potas
Publikováno v:
Oléagineux, Corps gras, Lipides, Vol 8, Iss 1, Pp 28-32 (2001)
The current investigations on fatty acids are focused on long chain fatty acids, trans fatty acids (TFA) and conjugated fatty acids (CFA), especially isomers of linoleic acid (CLA). This paper deals with the origins of TFA and CLA and their physiolog
Autor:
H. Wittig, Knut Dietzmann, M. Warich-Kirches, Regine Schneider-Stock, Thomas Schneider, Matthias Michael, Cornelia Woy, Elmar Kirches, Kirstin Winkler
Publikováno v:
Genes, Chromosomes and Cancer. 26:80-83
The aim of this study was the determination of D-loop heteroplasmy in astrocytic brain tumors. DNA fragments corresponding to the hypervariable region 2 of the mitochondrial displacement loop (D-loop) from 12 astrocytic tumors and 2 corresponding bra
Autor:
Elmar Kirches, Wolfram S. Kunz, Kirstin Winkler, M. Warich-Kirches, F. Wien, P. K. Bajaj, P. von Bossanyi, Knut Dietzmann, R. Szibor
Publikováno v:
Journal of Inherited Metabolic Disease. 21:400-408
The ratio of mtDNA and a nuclear reference gene was estimated by Southern blotting in the skeletal muscle DNA of a 3-year-old girl who suffered from congenital brain damage, focal epilepsy, hepatomegaly, malabsorption syndrome and severe myopathy. Th
Autor:
Andrey V. Kuznetsov, P. von Bossanyi, Kirstin Winkler, Knut Dietzmann, Falk R. Wiedemann, Wolfram S. Kunz
Publikováno v:
Molecular and Cellular Biochemistry. 183:87-96
The mdx mouse, an animal model of the Duchenne muscular dystrophy, was used for the investigation of changes in mitochondrial function associated with dystrophin deficiency. Enzymatic analysis of skeletal muscle showed an approximately 50% decrease i
Autor:
Iqbal Sayeed, Peter Schönfeld, Isabelle Trieu, Detlef Siemen, Suhel Parvez, Kirstin Winkler-Stuck, Claus-Werner Wallesch, Gordon Seitz
Publikováno v:
The FASEB Journal. 20:556-558
The dopamine-D2-agonist pramipexole (PPX) was tested for blocking mitochondrial permeability transition (PT) in order to give a possible explanation for its neuroprotective effect seen in PPX-treated Parkinson's disease patients. Patch-clamp techniqu
Publikováno v:
Analytical Biochemistry. 246:218-224
At 488 nm argon-ion laser excitation human mononuclear cells emit flavoprotein-related autofluorescence signals. Approximately 60% of these are caused by the mitochondrial flavoproteins alpha-lipoamide dehydrogenase and electron transfer flavoprotein