Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kirstin Castiglione"'
Autor:
Stefanie Westermann, Christoph Schubart, Axel Dietschmann, Kirstin Castiglione, Daniel Radtke, David Voehringer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011296 (2023)
Gastrointestinal helminths are a major health threat worldwide. Alternatively activated macrophages (AAMs) have been shown to contribute to host protection during secondary helminth infections. AAMs express effector molecules that depend on activatio
Externí odkaz:
https://doaj.org/article/3b4c9a548be54e7a81c549bf420874b9
Autor:
Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jürgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Eosinophilia is associated with various persisting inflammatory diseases and often coincides with chronic fungal infections or fungal allergy as in the case of allergic bronchopulmonary aspergillosis (ABPA). Here, we show that intranasal adm
Externí odkaz:
https://doaj.org/article/92daf7c4ba564f7e9c3b9b84d49251f7
Autor:
Stefanie Westermann, Axel Dietschmann, Daniela Doehler, Kirstin Castiglione, Bruce S. Bochner, David Voehringer, Daniel Radtke
Publikováno v:
J Immunol
Eosinophils are potent innate effector cells associated mainly with type 2 immune responses elicited by helminths and allergens. Their activity needs to be tightly controlled to prevent severe inflammation and tissue damage. Eosinophil degranulation
Autor:
Christian Bogdan, Jonathan Jantsch, Kirstin Castiglione, Alexander Mahnke, Valentin Schatz, Robert J. Meier, Otto S. Wolfbeis, Ulrike Schleicher, Julian Hofmann
Publikováno v:
Journal of Investigative Dermatology. 134:2339-2346
Cure of infections with Leishmania major is critically dependent on the ability of macrophages to induce the type 2 nitic oxide (NO) synthase (NOS2) that produces high levels of NO in the presence of ample oxygen. Therefore, we analyzed the oxygen le
Autor:
Joachim Gläsner, Jonathan Jantsch, Kirstin Castiglione, Ulrike Schleicher, Markus Schnare, Carsten Willam, David R. Mole, Melanie Wiese, Kai-Uwe Eckardt, Sophie Kolbe, Roland Lang, Johannes Schödel, Christian Bogdan, Michael Hensel
Publikováno v:
Europe PubMed Central
HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and for the inflammatory response of myeloid cells, including DCs. HIF1A is stabilized by hypoxia but also by TLR ligands under normoxic conditions. The un
Autor:
Michael Hensel, Melanie Wiese, Jonathan Jantsch, Ulrike Schleicher, Christian Bogdan, Kirstin Castiglione
Publikováno v:
Journal of Immunological Methods. 353:102-110
Selective gene silencing by RNA interference (RNAi) is a valuable tool for the targeted manipulation of the development and/or function of cells. Using a fluorescein-labeled non-silencing siRNA duplex, we established a protocol for the electroporatio
Autor:
Steffen Stenger, Matthias Engele, Martin Röllinghoff, Manfred Wagner, Nives Schwerdtner, Pal L. Bölcskei, Kirstin Castiglione, Elmar Stössel
Publikováno v:
The Journal of Immunology. 168:1328-1337
The ability of macrophages to release cytokines is crucial to the host response to intracellular infection. In particular, macrophage-derived TNF plays an important role in the host response to infection with the intracellular pathogen Mycobacterium
Autor:
Dipshikha Chakravortty, Jasmin Matuszak, Roman G. Gerlach, Isabel Popp, Michael Hensel, Melanie Wiese, Kirstin Castiglione, Christian Bogdan, Jonathan Jantsch, Mousumi Mahapatro, Carsten Willam
Publikováno v:
Infection and immunity. 80(4)
In infected tissues oxygen tensions are low. As innate immune cells have to operate under these conditions, we analyzed the ability of macrophages (Mϕ) to kill Escherichia coli or Staphylococcus aureus in a hypoxic microenvironment. Oxygen restricti