Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Kirstin, Scherlach"'
Autor:
Sebastian Schaefer, Raghav Vij, Jakob L. Sprague, Sophie Austermeier, Hue Dinh, Peter R. Judzewitsch, Sven Müller-Loennies, Taynara Lopes Silva, Eric Seemann, Britta Qualmann, Christian Hertweck, Kirstin Scherlach, Thomas Gutsmann, Amy K. Cain, Nathaniel Corrigan, Mark S. Gresnigt, Cyrille Boyer, Megan D. Lenardon, Sascha Brunke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract More than two million people worldwide are affected by life-threatening, invasive fungal infections annually. Candida species are the most common cause of nosocomial, invasive fungal infections and are associated with mortality rates above 4
Externí odkaz:
https://doaj.org/article/4855006eb2384c85b16fca8c8d5c88bf
Autor:
Alina Hoffmann, Ursula Steffens, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Anisja Harbig, Kirstin Scherlach, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by Streptomyces tendae HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a spaghetti-like phenotype i
Externí odkaz:
https://doaj.org/article/4833b7c76779426b9186573341897b4a
Autor:
Ingrid Richter, Silvia Radosa, Zoltán Cseresnyés, Iuliia Ferling, Hannah Büttner, Sarah P. Niehs, Ruman Gerst, Kirstin Scherlach, Marc Thilo Figge, Falk Hillmann, Christian Hertweck
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT The fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) for the production of the antimitotic toxin rhizoxin. Although rhizoxin is the causative agent of rice seedling blight, the toxinogenic bacterial-f
Externí odkaz:
https://doaj.org/article/27da3a3e12df45a180537acbc4fb32d2
Autor:
Alina Dietrich, Ursula Steffens, Mike Gajdiss, Anna-Lena Boschert, Jana Katharina Dröge, Christiane Szekat, Peter Sass, Imran T. Malik, Jan Bornikoel, Laura Reinke, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Harbig, Kirstin Scherlach, Heike Brötz-Oesterhelt, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Resistance to antibiotics is an increasing problem and necessitates novel antibacterial therapies. The polyketide antibiotics cervimycin A to D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-re
Externí odkaz:
https://doaj.org/article/0db489a7ff654f7297e365749f7a453f
Autor:
Kirstin Scherlach, Christian Hertweck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Natural products are an important source of bioactive compounds and have versatile applications in different fields, but their discovery is challenging. Here, the authors review the recent developments in genome mining for discovery of natural produc
Externí odkaz:
https://doaj.org/article/10d94552f2ba40d684c9be1a898649d7
Autor:
Lisa Mahler, Sarah P Niehs, Karin Martin, Thomas Weber, Kirstin Scherlach, Christian Hertweck, Martin Roth, Miriam A Rosenbaum
Publikováno v:
eLife, Vol 10 (2021)
Antibiotics from few culturable microorganisms have saved millions of lives since the 20th century. But with resistance formation, these compounds become increasingly ineffective, while the majority of microbial and with that chemical compound divers
Externí odkaz:
https://doaj.org/article/ac9e80e5e550417ab6c984afe0642d0c
Publikováno v:
Chemical Science. 14:103-112
Bacterial endosymbionts of the saprotrophic soil fungus Mortierella verticillata NRRL 6337 produce a previously unknown lipodepsipeptide, symbiosin, which boosts the anthelmintic activity of necroxime to protect the host against fungivorous nematodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb5ed5ba4b8d71288c57c48c9da4e6d
https://doi.org/10.1039/d2sc04167g
https://doi.org/10.1039/d2sc04167g
Autor:
Maria Cristina Stroe, Tina Netzker, Kirstin Scherlach, Thomas Krüger, Christian Hertweck, Vito Valiante, Axel A Brakhage
Publikováno v:
eLife, Vol 9 (2020)
Microorganisms produce numerous secondary metabolites (SMs) with various biological activities. Many of their encoding gene clusters are silent under standard laboratory conditions because for their activation they need the ecological context, such a
Externí odkaz:
https://doaj.org/article/308f7260697949bb9d5fdad18446aea5
Autor:
Daniel Heine, Neil A. Holmes, Sarah F. Worsley, Ana Carolina A. Santos, Tabitha M. Innocent, Kirstin Scherlach, Elaine H. Patrick, Douglas W. Yu, J. Colin Murrell, Paulo C. Vieria, Jacobus J. Boomsma, Christian Hertweck, Matthew I. Hutchings, Barrie Wilkinson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Acromyrmex ants cultivate fungus gardens that can be parasitized by Escovopsis sp., leading to colony collapse. Here, Heine et al. identify two secondary metabolites produced by Escovopsis that accumulate in Acromyrmex tissue, reduce behavioural defe
Externí odkaz:
https://doaj.org/article/2e969411613d435eba4ecc55f43f0883
Autor:
Laura V. Flórez, Kirstin Scherlach, Ian J. Miller, Andre Rodrigues, Jason C. Kwan, Christian Hertweck, Martin Kaltenpoth
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Burkholderia bacteria protect the offspring of Lagria beetles against pathogens. Here, Flórez et al. identify an antifungal polyketide that is likely encoded by a horizontally acquired gene cluster on the genome of a dominant, uncultured Burkholderi
Externí odkaz:
https://doaj.org/article/a234ab7eb1c8441fa4cd1a74031757ee