Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kirstie H. Stansfield"'
Autor:
Damaris Albores-Garcia, Kirstie H. Stansfield, Jennifer L. McGlothan, Zoran Bursac, Tomás R. Guilarte
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Exposure to heavy metals has been associated with psychiatric disorders and recent studies suggest an association between childhood lead (Pb2+) intoxication and schizophrenia (SZ). In animal models, Pb2+ exposure recapitulates key neuropathological a
Externí odkaz:
https://doaj.org/article/03ecfd937e4049999431881f3b89724c
Autor:
Kirstie H. Stansfield, Patric K. Stanton, Xiao-Lei Zhang, Meredith K. Loth, Jennifer L. McGlothan, Tomás R. Guilarte, Omid Miry
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 161(1)
Childhood lead (Pb2+) intoxication is a public health problem of global proportion. Lead exposure during development produces multiple effects on the central nervous system including impaired synapse formation, altered synaptic plasticity, and learni
Autor:
Hiroto Kuwabara, Mohab Alexander, John Hilton, William B. Mathews, Robert F. Dannals, Dean F. Wong, Kirstie H. Stansfield, Anil Kumar, Fabrizio Gasparini, Heather Valentine
Publikováno v:
Synapse. 68:565-573
Fenobam is a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5) with inverse agonist activity and is expected to contribute to the treatment of neuropsychiatric disorders involving dysfunction of mGluR5 including
Publikováno v:
BMC Pharmacology & Toxicology
Background Lead (Pb2+) exposure has been shown to impair presynaptic neurotransmitter release in both in vivo and in vitro model systems. The mechanism by which Pb2+ impairs neurotransmitter release has not been fully elucidated. In previous work, we
Publikováno v:
Toxicological Sciences. 127:277-295
Dysregulation of synaptic development and function has been implicated in the pathophysiology of neurodegenerative disorders and mental disease. A neurotrophin that has an important function in neuronal and synaptic development is brain-derived neuro
Publikováno v:
Brain Research. 1439:88-95
We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesi
Publikováno v:
Toxicological Sciences. 116:249-263
Lead (Pb(2+)) exposure is known to affect presynaptic neurotransmitter release in both in vivo and cell culture models. However, the precise mechanism by which Pb(2+) impairs neurotransmitter release remains unknown. In the current study, we show tha
Chronic cocaine or ethanol exposure during adolescence alters novelty-related behaviors in adulthood
Publikováno v:
Pharmacology Biochemistry and Behavior. 86:637-642
Adolescence is a time of high-risk behavior and increased exploration. This developmental period is marked by a greater probability to initiate drug use and is associated with an increased risk to develop addiction and adulthood dependency and drug u
Publikováno v:
Alcoholism: Clinical and Experimental Research. 30:812-818
Background: Baclofen, a GABAB agonist, has been found to decrease alcohol craving in humans and to nonselectively decrease ethanol intake in some rodent models. This experiment assessed the effects of repeated administration of baclofen on reinforcer
Publikováno v:
Developmental Brain Research. 159:119-125
Adolescence is a time of high risk behavior and increased exploration. This developmental period is marked by a greater probability to initiate drug use and is associated with an increased risk to develop addiction and adulthood dependency. Human ado