Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kirstie Childs"'
Autor:
Michel Hamon, Allan Fletcher, Kelly Jean Stanhope, R Corradetti, Anne McLenachan, Henri Gozlan, Vicki C. Middlefell, A. M. Laporte, Laurence Lanfumey, Geraldine Brown, David J. Bill, Deborah Jones, Kirstie Childs, Jane E. Hartley, Ian Anthony Cliffe, David Critchley, Colin T. Dourish, Elaine A. Forster
Publikováno v:
Behavioural Brain Research. 73:337-353
Although considerable progress has been made in characterising the 5-HT 1 A receptor using agonists, partial agonists or non-selective antagonists, further studies of 5-HT 1 A receptor function have been hindered by the lack of highly selective antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccc57af6644d8dc82498e7207824540
https://doi.org/10.1016/0166-4328(96)00118-0
https://doi.org/10.1016/0166-4328(96)00118-0
Autor:
John Robert Porter, David Critchley, Richard J. K. Taylor, Kirstie Childs, Anthony Shock, Julien Alistair Brown, Graham John Warrellow, Ted A.H. Parton, John Clifford Head, Sarah Catherine Archibald, Martyn Kim Robinson
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(5)
We describe a series of dehydrophenylalanine derivatives where the Z isomers are potent VLA-4 antagonists but are subject to rapid biliary clearance and the E isomers have poor activity but have a slower rate of clearance. These configurationally con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdb52164735b892925f4740ea62059e
https://pubmed.ncbi.nlm.nih.gov/12617895
https://pubmed.ncbi.nlm.nih.gov/12617895
Autor:
Ted A.H. Parton, Alex Zomaya, John Clifford Head, Anthony Shock, Brian Hutchinson, David Critchley, Graham John Warrellow, Julien Alistair Brown, Kirstie Childs, Martyn Kim Robinson, Sarah Catherine Archibald, John Robert Porter
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(12)
The SAR studies to optimise both potency and rate of clearance in the rat for a series of pyrimidine and pyridine based VLA-4 antagonists are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c146f192a183aa92e9b8d40054f1054
https://pubmed.ncbi.nlm.nih.gov/12039570
https://pubmed.ncbi.nlm.nih.gov/12039570
Autor:
Alex Zomaya, John Robert Porter, Ted A.H. Parton, Brian Hutchinson, David Critchley, John Clifford Head, Kirstie Childs, Graham John Warrellow, Anthony Shock, Martyn Kim Robinson, Sarah Catherine Archibald, Julien Alistair Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(12)
SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d99b25a281d7a2443c530160b4b52c
https://pubmed.ncbi.nlm.nih.gov/12039569
https://pubmed.ncbi.nlm.nih.gov/12039569
Autor:
David Critchley, John Robert Porter, Janeen Marsha Linsley, Kirstie Childs, Sarah Catherine Archibald, Rikki Peter Alexander, Ted A.H. Parton, Barry John Langham, Anthony Shock, Richard J. K. Taylor, Graham John Warrellow, Martyn Kim Robinson, John Clifford Head
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(7)
SAR studies aimed at improving the rate of clearance by the incorporation of a 3,4-diamino-3-cyclobutene-1,2-dione group as an amino acid isostere in a series of VLA-4 integrin antagonists are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8f96d7df9023c57ef2b4c728048193
https://pubmed.ncbi.nlm.nih.gov/11909715
https://pubmed.ncbi.nlm.nih.gov/11909715
Publikováno v:
European journal of pharmacology. 264(1)
Numerous studies have demonstrated the stimulatory effect of 5-HT 1A receptor agonists, such as 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT), on plasma corticotrophin (ACTH) levels in the rat. However, until recently the lack of a selective 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbe1809167889914ed9c0a255e959ef
https://pubmed.ncbi.nlm.nih.gov/7828650
https://pubmed.ncbi.nlm.nih.gov/7828650