Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kirstie A. De Jong"'
Autor:
Liam G. Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A. Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ42) in these diverse chronic diseases is obscure. Here we show that adipose tissue
Externí odkaz:
https://doaj.org/article/ade282758ba44938be3e4d25c0c6bdc1
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112433- (2023)
Summary: Lipolysis of stored triglycerides is stimulated via β-adrenergic receptor (β-AR)/3′,5′-cyclic adenosine monophosphate (cAMP) signaling and inhibited via phosphodiesterases (PDEs). In type 2 diabetes, a dysregulation in the storage/lipo
Externí odkaz:
https://doaj.org/article/2dd36d8aedc54828b414e6302086a30e
Autor:
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev
Publikováno v:
Cells, Vol 12, Iss 11, p 1543 (2023)
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isofo
Externí odkaz:
https://doaj.org/article/c301bbb2157d47f39041d05dc51f0267
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 5, p 163 (2022)
Obesity and type 2 diabetes (T2D) are on trend to become a huge burden across all ages. They cause harm to almost every organ, especially the heart. For decades, the incidence of heart failure with impaired diastolic function (or called heart failure
Externí odkaz:
https://doaj.org/article/b5dddb4b549a4fe78e3b496a1d1f3bd9
Autor:
Kirstie A. De Jong, Liam G. Hall, Mark C. Renton, Timothy Connor, Sheree D. Martin, Greg M. Kowalski, Christopher S. Shaw, Clinton R. Bruce, Kirsten F. Howlett, Sean L. McGee
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101105- (2020)
Objective: Protein kinase D (PKD) signaling has been implicated in stress-induced cardiac remodeling and function as well as metabolic processes including contraction-mediated cardiac glucose uptake. PKD has recently emerged as a nutrient-sensing kin
Externí odkaz:
https://doaj.org/article/f19a389a4e5441999563302ccad50888
Autor:
Nikoleta Pavlaki, Kirstie A. De Jong, Birgit Geertz, Viacheslav O. Nikolaev, Alexander Froese
Publikováno v:
Cells, Vol 10, Iss 3, p 535 (2021)
3′,5′-Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger which plays critical roles in cardiac function and disease. In adult mouse ventricular myocytes (AMVMs), several distinct functionally relevant microdomains with tightly
Externí odkaz:
https://doaj.org/article/3f4994f0220a42a5876fb76751398b50
Autor:
Kirstie A. De Jong, Juliane K. Czeczor, Smithamol Sithara, Kevin McEwen, Gary D. Lopaschuk, Alan Appelbe, Kimberly Cukier, Mark Kotowicz, Sean L. McGee
Publikováno v:
Cardiovascular Diabetology, Vol 16, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/81471009bc0a4e3a8458e54138833d26
Autor:
Nikolaev, Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O.
Publikováno v:
Cells; Volume 12; Issue 11; Pages: 1543
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isofo
Autor:
Liam G Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. While some common aetiological mechanisms are known, the role of amyloid beta 42 (Aβ42) in these diverse chronic diseases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7713650f077407ca0d354131f4b65baa
https://doi.org/10.1101/2022.10.02.510555
https://doi.org/10.1101/2022.10.02.510555
Autor:
Christiane Jungen, Christian Meyer, John D. Tompkins, Pradeep S. Rajendran, Kirstie A. De Jong, Frederik Flenner, Katharina Scherschel, Viacheslav O. Nikolaev, Jeffrey L. Ardell, Haesung Jee
Publikováno v:
Am J Physiol Heart Circ Physiol
Patients with type 2 diabetes mellitus (T2DM) have a greater risk of developing life-threatening cardiac arrhythmias. Because the underlying mechanisms and potential influence of diabetic autonomic neuropathy are not well understood, we aimed to asse