Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kirstie A De Jong"'
Autor:
Kirstie A De Jong, Filip Berisha, Negar Naderpoor, Alan Appelbe, Mark A Kotowicz, Kimberly Cukier, Sean L McGee, Viacheslav O Nikolaev
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263312 (2022)
BackgroundIt remains unclear as to whether polycystic ovary syndrome (PCOS) is an additional risk factor in the development of left ventricular (LV) hypertrophy in obese women. In the current study, we provide clarity on this issue by rigorously anal
Externí odkaz:
https://doaj.org/article/44230b75c9934246b8916185b4922a38
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189492 (2017)
Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subseq
Externí odkaz:
https://doaj.org/article/90c2526edbf04d3f910a29dad5ec213c
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120934 (2015)
The development of diabetic cardiomyopathy is a key contributor to heart failure and mortality in obesity and type 2 diabetes (T2D). Current therapeutic interventions for T2D have limited impact on the development of diabetic cardiomyopathy. Clearly,
Externí odkaz:
https://doaj.org/article/65b7330d75cf41be85697396b8df9b81
Autor:
Liam G. Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A. Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ42) in these diverse chronic diseases is obscure. Here we show that adipose tissue
Externí odkaz:
https://doaj.org/article/ade282758ba44938be3e4d25c0c6bdc1
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112433- (2023)
Summary: Lipolysis of stored triglycerides is stimulated via β-adrenergic receptor (β-AR)/3′,5′-cyclic adenosine monophosphate (cAMP) signaling and inhibited via phosphodiesterases (PDEs). In type 2 diabetes, a dysregulation in the storage/lipo
Externí odkaz:
https://doaj.org/article/2dd36d8aedc54828b414e6302086a30e
Autor:
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev
Publikováno v:
Cells, Vol 12, Iss 11, p 1543 (2023)
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isofo
Externí odkaz:
https://doaj.org/article/c301bbb2157d47f39041d05dc51f0267
Autor:
Nikolaev, Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O.
Publikováno v:
Cells; Volume 12; Issue 11; Pages: 1543
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a5d4791e9430863dccb40c6c37aaa8c2
Autor:
Liam G Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. While some common aetiological mechanisms are known, the role of amyloid beta 42 (Aβ42) in these diverse chronic diseases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7713650f077407ca0d354131f4b65baa
https://doi.org/10.1101/2022.10.02.510555
https://doi.org/10.1101/2022.10.02.510555
Autor:
Christiane Jungen, Christian Meyer, John D. Tompkins, Pradeep S. Rajendran, Kirstie A. De Jong, Frederik Flenner, Katharina Scherschel, Viacheslav O. Nikolaev, Jeffrey L. Ardell, Haesung Jee
Publikováno v:
Am J Physiol Heart Circ Physiol
Patients with type 2 diabetes mellitus (T2DM) have a greater risk of developing life-threatening cardiac arrhythmias. Because the underlying mechanisms and potential influence of diabetic autonomic neuropathy are not well understood, we aimed to asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1e953a1867dd9aca4411e8f07c85fe
https://doi.org/10.1152/ajpheart.00249.2019
https://doi.org/10.1152/ajpheart.00249.2019