PV interneurons evoke astrocytic Ca2+ responses in awake mice, which contributes to neurovascular coupling

Autor: Aske Krogsgaard, Leonora Sperling, Matilda Dahlqvist, Kirsten Thomsen, Gabriele Vydmantaite, Fangyuan Li, Martin Thunemann, Martin Lauritzen, Barbara Lykke Lind

Publikováno v: Krogsgaard, A, Sperling, L, Dahlqvist, M, Thomsen, K, Vydmantaite, G, Li, F, Thunemann, M, Lauritzen, M & Lind, B L 2023, ' PV interneurons evoke astrocytic Ca 2+ responses in awake mice, which contributes to neurovascular coupling. ', Glia, vol. 71, no. 8 . https://doi.org/10.1002/glia.24370

Neurovascular coupling (NVC) modulates cerebral blood flow to match increased metabolic demand during neuronal excitation. Activation of inhibitory interneurons also increase blood flow, but the basis for NVC caused by interneurons is unclear. While

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe56ca5660aaf693d305893e12cf30db
https://curis.ku.dk/ws/files/357072814/Glia_2023_Krogsgaard_PV_interneurons_evoke_astrocytic_Ca2_responses_in_awake_mice_which_contributes_to.pdf

Astrocytic Ca2+ signals partake in inhibitory neurovascular coupling in a brain state-dependent manner

Autor: Aske Krogsgaard, Leonora Sperling, Matilda Dahlqvist, Kirsten Thomsen, Gabriele Vydmantaite, Martin Lauritzen, Barbara Lykke Lind

Neurovascular coupling (NVC) modulates cerebral blood flow to match increased metabolic demand during neuronal excitation. Activation of inhibitory interneurons also increase blood flow, but the basis for this inhibitory NVC is unclear. We performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b728e7e82c6edc955edd83bb34b92434
https://doi.org/10.1101/2022.02.23.478942

Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium

Autor: Karsten Skovgaard Olsen, Kirsten Thomsen, Krisztina Benedek, Esben Vedel-Larsen, Anne Øberg Lauritsen, Kirsten Møller, Rikke M. Nielsen, Heidi Shil Eddelien, Olalla Urdanibia-Centelles, Martin Lauritzen

Publikováno v: Neurocritical Care. 32:121-130

Delirium is common during sepsis, although under-recognized. We aimed to assess the value of continuous electroencephalography (cEEG) to aid in the diagnosis of delirium in septic patients. We prospectively evaluated 102 consecutive patients in a med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5906367fa6206b703a892112d0b4226
https://doi.org/10.1007/s12028-019-00703-w

Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus

Autor: Takashi Yokota, Nima Borhan Fakouri, Steen Larsen, Flemming Dela, Kirsten Thomsen, Claus Desler, Christine Elisabeth Regnell, Lene Juel Rasmussen, Linda H. Bergersen, Niloofar Sherazi, Mahdi Hasan-Olive, Martin Lauritzen

Publikováno v: Neurobiology of Aging. 61:215-224

Brain aging is accompanied by declining mitochondrial respiration. We hypothesized that mitochondrial morphology and dynamics would reflect this decline. Using hippocampus and frontal cortex of a segmental progeroid mouse model lacking Cockayne syndr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7700de26b81fb2884a84b10dce2083
https://doi.org/10.1016/j.neurobiolaging.2017.08.004

Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

Autor: Dmitry D. Postnov, Matilda K Dahlqvist, Kirsten Thomsen, Martin Lauritzen

Publikováno v: J Cereb Blood Flow Metab

Gamma activity arises from the interplay between pyramidal neurons and fast-spiking parvalbumin (PV) interneurons, is an integral part of higher cognitive functions and is assumed to contribute importantly to brain metabolic responses. Cerebral metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42cd47e32ca3a2d2b31261d020544ef
https://pubmed.ncbi.nlm.nih.gov/31645177