Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kirsten Storch"'
Publikováno v:
Annual Review of Pharmacology and Toxicology. 62:341-363
Innovative formulation technologies can play a crucial role in transforming a novel molecule to a medicine that significantly enhances patients’ lives. Improved mechanistic understanding of diseases has inspired researchers to expand the druggable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527debb20e1a5466a013021eab01017d
https://doi.org/10.1146/annurev-pharmtox-052120-093517
https://doi.org/10.1146/annurev-pharmtox-052120-093517
Autor:
Daniel Paul DeCollibus, Justin Searcy, Anna Tivesten, Nadim Akhtar, Christian Lindenberg, Nounja Abarrou, Sujana Pradhan, Maggie Fiandaca, Jenny Franklin, Geetha Govindan, Hung-Yi Liu, David Royle, Patrick Lim Soo, Kirsten Storch
Publikováno v:
Nucleic Acid Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c1b55466799bc84b942f6b5eeca5df
https://doi.org/10.1089/nat.2022.0073
https://doi.org/10.1089/nat.2022.0073
Autor:
John H. A. Amery, Stefan Andreas Lange, Hill Malcolm Leithhead, Robert Simler, Leigh Dixon, Frank Gielen, Cinzia Gazziola, Doug P. Nesta, Jale Muslehiddinoglu, Kirsten Storch, Claudia Mueller, Jeremy D. Prail, Anna L. Watson
Publikováno v:
Nucleic Acid Therapeutics
The most common approach for the manufacture of oligonucleotides includes isolation of the active pharmaceutical ingredient (API) via lyophilization to provide a solid product, which is then dissolved to provide an aqueous formulation. It is well kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aaafb3daa2f2511a77619b48c69f0a
https://doi.org/10.1089/nat.2020.0846
https://doi.org/10.1089/nat.2020.0846
Publikováno v:
International journal of pharmaceutics. 553(1-2)
Co-administration of solid oral dosage forms with soft food or beverages is commonly used to facilitate administration and to improve compliance in the paediatric and geriatric population and in patient groups with swallowing difficulties. The presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e467bdc032bccdd88f45cb25f118b020
https://pubmed.ncbi.nlm.nih.gov/30393169
https://pubmed.ncbi.nlm.nih.gov/30393169
Autor:
Gerhard Becker, Johanna Poecheim, Kirsten Storch, Miriam Printz, Joerg Hoernschemeyer, Kirsten Graeser
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 129
Oligonucleotide-based therapeutics have been implemented as a new therapeutic modality in biotech industry, which offers the opportunity to develop formulation platforms for robust parenteral formulations. The aim of this study was to gain a better u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264186fb391fe47dd86b17e77cc69807
https://pubmed.ncbi.nlm.nih.gov/29802983
https://pubmed.ncbi.nlm.nih.gov/29802983
Autor:
Daniel Rauh, Benjamin Baur, Márcia Inês Goettert, Stefan Laufer, Kirsten Storch, André Richters, Kathrin E. Martz
Publikováno v:
Journal of Medicinal Chemistry. 56:8561-8578
Five series of metabolically stable disubstituted dibenzo[b,e]oxepin-11(6H)-ones were synthesized and tested in a p38α enzyme assay for their inhibition of tumor necrosis factor-α (TNF-α) release in human whole blood. Compared to the monosubstitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca37bfa29c5bb75303533f0888d9c91
https://doi.org/10.1021/jm401276h
https://doi.org/10.1021/jm401276h
Autor:
Stefan Fischer, Christian Grütter, Stefan Laufer, Silke M. Bauer, Daniel Rauh, Solveigh C. Koeberle, Kirsten Storch, Svenja C. Mayer-Wrangowski, Frank M. Boeckler, Heike K. Wentsch, Markus O. Zimmermann, Raimund Niess
Publikováno v:
Journal of Medicinal Chemistry. 56:241-253
p38α mitogen-activated protein (MAP) kinase is a main target in drug research concerning inflammatory diseases. Nevertheless, no inhibitor of p38α MAP kinase has been introduced to the market. This might be attributed to the fact that there is no i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17fb412e5cb0930f41132ad98c8edf8
https://doi.org/10.1021/jm301539x
https://doi.org/10.1021/jm301539x
Publikováno v:
MedChemComm. 5:808
The p38 mitogen-activated protein kinase (MAPK) is a key mediator in cytokine-induced signaling events and is activated in response to a variety of extracellular stimuli such as stress factors, UV-light and inflammatory cytokines. Therefore, the p38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81010c37c5338ef0becf026812881480
https://doi.org/10.1039/c4md00106k
https://doi.org/10.1039/c4md00106k