Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kirsten Schorning"'
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background An important problem in toxicology in the context of gene expression data is the simultaneous inference of a large number of concentration–response relationships. The quality of the inference substantially depends on the choice
Externí odkaz:
https://doaj.org/article/07aba6c788e244269f4476d0232db5e8
Autor:
Christine H. Müller, Kirsten Schorning
Publikováno v:
Statistical Papers.
We consider two models for estimating the expected states of nodes in networks where the observations at nodes are given by random states and measurement errors. In the first model, we assume independent successive observations at the nodes and the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f17cd2b90d294cb5f6c561a7b92d120
https://doi.org/10.1007/s00362-023-01435-y
https://doi.org/10.1007/s00362-023-01435-y
Publikováno v:
BiometricsREFERENCES.
The determination of alert concentrations, where a pre-specified threshold of the response variable is exceeded, is an important goal of concentration-response studies. The traditional approach is based on investigating the measured concentrations an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0f74ab32d8ce7acd5078683bc2c281
https://pubmed.ncbi.nlm.nih.gov/36385693
https://pubmed.ncbi.nlm.nih.gov/36385693
In this paper we construct optimal designs for frequentist model averaging estimation. We derive the asymptotic distribution of the model averaging estimate with fixed weights in the case where the competing models are non-nested. A Bayesian optimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b995f0976eae3f9371ef2087ca744b
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/9713
https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/9713
Autor:
Kirsten Schorning, Holger Dette
We consider the problem of designing experiments for the comparison of two regression curves describing the relation between a predictor and a response in two groups, where the data between and within the group may be dependent. In order to derive ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344464474d89f7b572d18d02174d020c
http://arxiv.org/abs/2101.05654
http://arxiv.org/abs/2101.05654
Publikováno v:
Statistics. 52:1359-1378
In this paper, we present a new method for determining optimal designs for enzyme inhibition kinetic models, which are used to model the influence of the concentration of a substrate and an...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::901f4b4a6264d324788270fb20645dcf
https://doi.org/10.1080/02331888.2018.1511716
https://doi.org/10.1080/02331888.2018.1511716
Publikováno v:
Biometrika, vol 104, 4
Biometrika
Biometrika
Summary We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c2e73d8b89b2b676a705808cbb173b
https://doi.org/10.1093/biomet/asx057
https://doi.org/10.1093/biomet/asx057
Publikováno v:
Statistics in Medicine. 35:4021-4040
A key objective of Phase II dose finding studies in clinical drug development is to adequately characterize the dose response relationship of a new drug. An important decision is then on the choice of a suitable dose response function to support dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6579d12de12da8c138f4a647e0efa0f5
https://doi.org/10.1002/sim.6991
https://doi.org/10.1002/sim.6991
Publikováno v:
Journal of the Royal Statistical Society Series C: Applied Statistics. 66:53-72
Summary We consider the problem of designing additional experiments to update statistical models for latent day specific effects. The problem appears in thermal spraying, where particles are sprayed on surfaces to obtain a coating. The relationships
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::884e40aa35bb79ef9abe2cb7f755318f
https://doi.org/10.1111/rssc.12156
https://doi.org/10.1111/rssc.12156
Autor:
Holger Dette, Kirsten Schorning
Publikováno v:
Faszination Statistik ISBN: 9783662605615
Nur wenige potenzielle Arzneistoffe bestehen die klinischen Tests und werden zugelassen. Mit besseren statistischen Verfahren fur die Dosisfindung konnte sich die Zahl der erfolgreichen Substanzen erhohen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebabb58cb39965e342a9d05a9b75f48d
https://doi.org/10.1007/978-3-662-60562-2_3
https://doi.org/10.1007/978-3-662-60562-2_3