Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kirsten S. Smith"'
Autor:
IGOR OPSENICA, DEJAN OPSENICA, MILKA JADRANIN, KIRSTEN S. SMITH, WILBUR K. MILHOUS, MANOLIS STRATAKIS, BOGDAN ŠOLAJA
Publikováno v:
Journal of the Serbian Chemical Society, Vol 72, Iss 12, Pp 1181-1190 (2007)
Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure–activity relationship of this kind of antimalarials. The tetraoxanes 2–5, obtained as a cis/trans mixture, showed pronounced antimalarial activi
Externí odkaz:
https://doaj.org/article/043a0b998e2749609c8194dc9750d498
Autor:
Merlin L. Robb, Suchai Kitsiripornchai, Supachai Rerks Ngarm, Leilani Francisco, Sandhya Vasan, Warong Leela-Apiradee, Trevor A Crowell, Kirsten S. Smith, Elizabeth Heger, Qun Li, Thawat Tiawilai, Robert J. O'Connell, Siriwat Akapirat, Chawestan Namwat, Nicole Dear, Mark M. Fukuda, Tanyaporn Wansom
Background In Thailand, HIV transmission is well characterized in large urban centers such as Bangkok and Chiang Mai but less so outside of these areas. We assessed HIV incidence and associated risk factors in two other locations. Methods Participant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::141547f734e9c3b526792a5f7e03c99a
https://doi.org/10.21203/rs.3.rs-848525/v1
https://doi.org/10.21203/rs.3.rs-848525/v1
Autor:
Sant Muangnoicharoen, Kirsten S. Smith, Tanyaporn Wansom, Jittima Dhitavat, David King, Sorachai Nitayaphan, Merlin L. Robb, Paileen Gilbert, Sandhya Vasan, Robert J. O'Connell, Suchai Kitsiripornchai, Leilani Francisco, Trevor A Crowell, Elizabet A. Heger, Qun Li, Punnee Pitisutthithum, Dixion Rwakasyaguri
Publikováno v:
SSRN Electronic Journal.
Background: In order to assess feasibility for future HIV prevention trials, we measured HIV incidence, retention, and assessed risk factors for seroconversion among men who have sex with men (MSM) and transgender women (TGW) in Bangkok, Thailand bet
Autor:
Sorachai Nitayaphan, Qun Li, Kirsten S. Smith, Siriwat Akapirat, Tanyaporn Wansom, David King, Punnee Pitisuttithum, Robert J. O'Connell, Merlin L. Robb, Suchai Kitsiripornchai, Sandhya Vasan, Leilani Francisco, Sant Muangnoicharoen, Jittima Dhitavat, Dixion Rwakasyaguri, Trevor A Crowell, Elizabeth Heger, Paileen Gilbert
Publikováno v:
EClinicalMedicine, Vol 38, Iss, Pp 101033-(2021)
EClinicalMedicine
EClinicalMedicine
Background We measured Human Immunodeficiency (HIV) incidence, retention, and assessed risk factors for seroconversion among two previously unreported cohorts of men who have sex with men (MSM) and Transgender Women (TGW) in Bangkok, Thailand between
Autor:
Meng Shi, Jay W. Hooper, Nelson L. Michael, Shon Remich, James E. Moon, Judie B. Alimonti, Nicole M. Van Deusen, Paula Muñoz, Jocelyn Voell, Richard T. Davey, Barney S. Graham, Peter Silvera, Zonghui Hu, Linda L. Jagodzinski, H. Clifford Lane, Ramiro L. Gutierrez, Yan Zhou, Matthew D. Josleyn, Amy R. Castellano, John H. Beigel, Steven A. Kwilas, Patrick S. Twomey, Daphne A. Stanley, Kirsten S. Smith, Charles J. Link, Brian K. Martin, Kristopher M. Paolino, Wang Jing, W. Jay Ramsey, Holly R. Hack, Jason W. Bennett, Jason A. Regules, Olivier Tshiani Mbaya, Richard C. Ruck, Sheila A. Peel, Stephen J. Thomas, Nancy J. Sullivan, Julie E. Ledgerwood, Thomas P. Monath, Meagan L. Wisniewski
Publikováno v:
New England Journal of Medicine. 376:330-341
The worst Ebola virus disease (EVD) outbreak in history has resulted in more than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an attenuated, replication-competent, recombinant vesicular stomatitis virus (rVSV
Autor:
Peter Dawson, Jaranit Kaewkungwal, Faruk Sinangil, Elizabeth Heger, Lindsay Wieczorek, James Tartaglia, Punnee Pitisuttithum, Rv Study Team, Alexandra Schuetz, Sanjay Phogat, Carlos A. DiazGranados, Suwat Chariyalertsak, Nelson L. Michael, Kirsten S. Smith, Merlin L. Robb, Jerome H. Kim, Victoria R. Polonis, Siriwat Akapirat, Benjaluck Phonrat, Surat Jongrakthaitae, Sandhya Vasan, Michael A. Eller, Yingjun Zhou, Dohoon Kim, Robert J. O'Connell, Nicos Karasavvas, Jittima Dhitavat, Jean-Louis Excler, Sorachai Nitayapha, Poonam Pegu
Publikováno v:
SSRN Electronic Journal.
Background: The RV144 phase 3 vaccine trial in Thailand demonstrated that ALVAC-HIV (vCP1521) and AIDSVAX® B/E administration over six months resulted in a 31% efficacy in preventing HIV acquisition. Subsequent boosting of RV144 vaccine recipients 6
Publikováno v:
Open Journal of Synthesis Theory and Applications. :91-96
The triterpene quassinoid ailanthinone is a structurally intricate natural product possessing highly potent antimalarial activity against multidrug resistance plasmodium parasites. Although the mechanism of action of ailanthinone is not completely un
Autor:
Mihaela Perić, Wilbur K. Milhous, Nedjeljko Kujundžić, Jasna Padovan, Zrinka Ivezić Schönfeld, Andrea Fajdetić, Kirsten S. Smith, Dubravko Jelić, Colin Ohrt, Wolfgang Schönfeld, William Y. Ellis, Arba L. Ager, Radan Spaventi, Dinko Žiher, Mirjana Bukvić Krajačić, Goran Landek
Publikováno v:
Journal of Medicinal Chemistry. 54:3595-3605
Azithromycin, a first member of the azalide family of macrolides, while having substantial antimalarial activity, failed as a single agent for malaria prophylaxis. In this paper we present the first analogue campaign to identify more potent compounds
Autor:
Colin Ohrt, Kirsten S. Smith, Antun Hutinec, Wilbur K. Milhous, Renata Rupčić, Zrinka Ivezić Schönfeld, William Y. Ellis, Dinko Žiher
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1692-1701
A series of 15-membered azalide urea and thiourea derivatives has been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive (D6), chloroquine/pyremethamine resistant (W2) and multidrug resistant (TM91C235)
Autor:
Wilbur K. Milhous, Charlotte A. Lanteri, Kirsten S. Smith, Dejan Opsenica, Lalaine Anova, Bogdan A. Šolaja, Igor Opsenica
Publikováno v:
Journal of Medicinal Chemistry
The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalarial activities, with IC90 values for the Plasmodium