Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kirsten R. McEwen"'
Autor:
Sung Pil Hong, Thalia E. Chan, Ylenia Lombardo, Giacomo Corleone, Nicole Rotmensz, Sara Bravaccini, Andrea Rocca, Giancarlo Pruneri, Kirsten R. McEwen, R. Charles Coombes, Iros Barozzi, Luca Magnani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The development of resistance to endocrine therapy is a significant, clinical problem in breast cancer. Here, the authors identify a rare subpopulation of cells that drive resistance following transcriptional reprogramming.
Externí odkaz:
https://doaj.org/article/266ee5cecff04b52b1a25a258b6d6db4
Autor:
Giacomo Corleone, Giancarlo Pruneri, Nicole Rotmensz, Andrea Rocca, Kirsten R. McEwen, Sara Bravaccini, Charles Coombes, Iros Barozzi, Thalia E. Chan, Sung Pil Hong, Ylenia Lombardo, Luca Magnani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Resistant tumours are thought to arise from the action of Darwinian selection on genetically heterogenous cancer cell populations. However, simple clonal selection is inadequate to describe the late relapses often characterising luminal breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd06216316ffa9b948132d37d4a25874
http://link.springer.com/article/10.1038/s41467-019-11721-9
http://link.springer.com/article/10.1038/s41467-019-11721-9
Autor:
Asano M, Godfrey Cf Chan, Naruse C, Pui Pik Law, Zhi H, Kirsten R. McEwen, Kian Cheng Tan-Un, Ping Kei Chan, Liang B, Richard Festenstein
SummarySex differences in growth rate in very early embryos have been recognized in a variety of mammals and attributed to sex-chromosome complement effects as they occur before overt sexual differentiation. We previously found that sex-chromosome co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de3e283e0364525b5d7c4867dc76a6c
Autor:
Giacomo Corleone, Kirsten R. McEwen, Nicole Rotmensz, Charles Coombes, Sung Pil Hong, Iros Barozzi, Giancarlo Pruneri, Ylenia Lombardo, Luca Magnani, Thalia E. Chan
Resistant tumours are thought to arise from the action of Darwinian selection on genetically heterogenous cancer cell populations. However, simple clonal selection is inadequate to describe the late relapses often characterising luminal breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfb13594bd20f0fca3ceaf45b03caa4
Autor:
Al-Zouabi L, Enrico Petretto, Petra Hajkova, Huang T, Sardini A, Sarah Filippi, Kirsten R. McEwen, Michael P. H. Stumpf, Prashant K. Srivastava, Harry G. Leitch, Sarah Linnett, Thalia E. Chan, Maxime Rotival
Pluripotent stem cells (PSCs) can self-renew indefinitely while maintaining the ability to generate all cell types of the body. This plasticity is proposed to require heterogeneity in gene expression, driving a metastable state which may allow flexib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cab992c30fb3f89382a1e598188ff62
https://doi.org/10.1101/373373
https://doi.org/10.1101/373373
Gene expression is controlled by networks of transcription factors and regulators, but the structure of these networks is as yet poorly understood and is thus inferred from data. Recent work has shown the efficacy of information theoretical approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615b7e3165adb80ab955fc0c3608add8
Publikováno v:
Biochemical Society Transactions. 41:711-719
Cultured pluripotent stem cells hold great promise for regenerative medicine. Considerable efforts have been invested into the refinement and definition of improved culture systems that sustain self-renewal and avoid differentiation of pluripotent ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04601248e3c790ab2ee995064204a73
https://doi.org/10.1042/bst20130049
https://doi.org/10.1042/bst20130049
Autor:
Austin Smith, Buhe Nashun, Nils Grabole, William Mansfield, Thomas L. Carroll, Aleksandra Turp, M. Azim Surani, Kirsten R. McEwen, Vesela Encheva, Harry G. Leitch, Petra Hajkova, Jaysen G Knezovich
Publikováno v:
Nature structural & molecular biology
Naïve pluripotent embryonic stem (ESCs) cells and embryonic germ (EGCs) cells are derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively. We investigated whether differences exist between ESCs and EGCs in view of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34feaae3c12d0cacb6d6229b285d3642
https://doi.org/10.1038/nsmb.2510
https://doi.org/10.1038/nsmb.2510
The recent discovery of Tet (Ten eleven translocation) family of enzymes implicated in the chemical conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxycytosine (5caC) has significantly enlarg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37aa0d85f228a8c4c2c91dee873f72c9
http://hdl.handle.net/10044/1/29783
http://hdl.handle.net/10044/1/29783
Autor:
Philip A. Beer, Eva Hellström-Lindberg, Anne C. Ferguson-Smith, Mitsuteru Ito, Mary Frances McMullin, Anthony R. Green, Yvonne Silber, Anthony J. Bench, Jean-Jacques Kiladjian, E. Joanna Baxter, Clara Y. Cheong, Kirsten R. McEwen, Keefe Chng, Rebecca L. Kelley, Jyoti Nangalia, Ghulam J. Mufti, Peter J. Campbell, Carol A. Edwards, Athar Aziz, Dionne Gray, Marilyn B. Renfree
Publikováno v:
Clinical Epigenetics
Europe PubMed Central
Aziz, A, Baxter, E J, Edwards, C, Cheong, C Y, Ito, M, Bench, A, Kelley, R, Silber, Y, Beer, P A, Chng, K, Renfree, M B, McEwen, K, Gray, D, Nangalia, J, Mufti, G J, Hellstrom-Lindberg, E, Kiladjian, J-J, McMullin, M F, Campbell, P J, Ferguson-Smith, A C & Green, A R 2013, ' Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions ', The Journal of clinical investigation, vol. 123, no. 5, pp. 2169-2182 . https://doi.org/10.1172/JCI66113
Europe PubMed Central
Aziz, A, Baxter, E J, Edwards, C, Cheong, C Y, Ito, M, Bench, A, Kelley, R, Silber, Y, Beer, P A, Chng, K, Renfree, M B, McEwen, K, Gray, D, Nangalia, J, Mufti, G J, Hellstrom-Lindberg, E, Kiladjian, J-J, McMullin, M F, Campbell, P J, Ferguson-Smith, A C & Green, A R 2013, ' Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions ', The Journal of clinical investigation, vol. 123, no. 5, pp. 2169-2182 . https://doi.org/10.1172/JCI66113
Large regions of recurrent genomic loss are common in cancers; however, with a few well-characterized exceptions, how they contribute to tumor pathogenesis remains largely obscure. Here we identified primate-restricted imprinting of a gene cluster on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11c843aa917dfe1efb4b7390b06d3c3
https://usir.salford.ac.uk/id/eprint/31910/1/AZIZ.pdf
https://usir.salford.ac.uk/id/eprint/31910/1/AZIZ.pdf