Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kirsten R. Bergmann"'
Autor:
Marije E. Otto, Kirsten R. Bergmann, Marieke L. deKam, Kasper Recourt, Gabriël E. Jacobs, Michiel J. vanEsdonk
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1425-1436 (2023)
Abstract In clinical trials, Montgomery‐Åsberg Depression Rating Scale (MADRS) questionnaire data are added up to total scores before analysis, assuming equal contribution of each separate question. Item Response Theory (IRT)‐based analysis avoi
Externí odkaz:
https://doaj.org/article/b368b3900d9748bb820769f968d0f7b2
Autor:
Cécile L. Berends, Lisa Pagan, Michiel J. vanEsdonk, Naomi B. Klarenbeek, Kirsten R. Bergmann, Matthijs Moerland, Vincent van derWel, Saco J. deVisser, Hans Büller, Frans deLoos, Wouter S. deVries, Hans Waals, Leo G. J. deLeede, Jacobus Burggraaf, Ingrid M. C. Kamerling
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Abstract The strict intake regimen of cysteamine bitartrate formulations, associated with side effects, is a concern for the treatment compliance in cystinosis therapy. Therefore, there is a need for a cysteamine formulation with an improved pharmaco
Externí odkaz:
https://doaj.org/article/7edf448348d44fbf8dec9db02864388c
Autor:
Charlotte Bakker, Jasper van derAart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. vanEsdonk, Denis G. Kay, Geert Jan Groeneveld
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Gln‐1062 (MEMOGAIN) is an intranasally administered lipophilic prodrug of galantamine. Based on high brain‐to‐blood concentrations observed in pre‐clinical studies, Gln‐1062 is expected to have superior cognitive effic
Externí odkaz:
https://doaj.org/article/a354bb9655804faf9b6e8de71a99a031
Autor:
Geert Jan Groeneveld, Erica S. Klaassen, Ingrid M C Kamerling, Emilie M. J. van Brummelen, Vanessa Ville, Annie-Claude Benichou, Cécile L. Berends, Kirsten R. Bergmann, Laurence M Moss, Victor Juarez-Perez
Publikováno v:
British Journal of Clinical Pharmacology, 88(1), 103-114. WILEY
Aim Dual enkephalinase inhibitors (DENKIs) are involved in the regulation of nociception via opioid receptors. The novel compound STR-324 belongs to the DENKI pharmacological class. This first-in-human study evaluated the safety, tolerability, pharma
Autor:
Mahdi Saghari, Pim Gal, Sally Gilbert, Martin Yateman, Ben Porter‐Brown, Nuala Brennan, Sonia Quaratino, Rosamund Wilson, Hendrika W. Grievink, Erica S. Klaassen, Kirsten R. Bergmann, Jacobus Burggraaf, Martijn B. A. Doorn, John Powell, Matthijs Moerland, Robert Rissmann
Publikováno v:
Clinical Pharmacology & Therapeutics, 111(5), 1121-1132. WILEY
Clinical Pharmacology and Therapeutics, 111(5), 1121-1132. Wiley-Blackwell
Clinical Pharmacology & Therapeutics, 111(5), 1121-1132
Clinical Pharmacology and Therapeutics, 111(5), 1121-1132. Wiley-Blackwell
Clinical Pharmacology & Therapeutics, 111(5), 1121-1132
The safety, tolerability, immunogenicity, and pharmacokinetic (PK) profile of an anti-OX40L monoclonal antibody (KY1005, currently amlitelimab) were evaluated. Pharmacodynamic (PD) effects were explored using keyhole limpet hemocyanin (KLH) and tetan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b192edac11ba0b76d50af7f90aca16d
https://hdl.handle.net/1887/3483886
https://hdl.handle.net/1887/3483886
Autor:
Tobias E Larsson, Hartmut Onkels, Sven Hoefman, Nelleke Snelder, Kirsten R. Bergmann, Alberto Garcia-Hernandez
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
ASP8232 is a novel inhibitor of vascular adhesion protein-1 that was under evaluation for reducing residual albuminuria in patients with diabetic kidney disease. To characterize the pharmacokinetics (PK) of ASP8232 and its effect on vascular adhesion
Autor:
Nelleke Snelder, Tobias E Larsson, Sven Hoefman, Kirsten R. Bergmann, Alberto Garcia-Hernandez, Martijn van Noort, Hartmut Onkels
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics
The vascular adhesion protein-1 (VAP-1) inhibitor ASP8232 reduces albuminuria in patients with type 2 diabetes and chronic kidney disease. A mechanism-based model was developed to quantify the effects of ASP8232 on renal markers from a placebo-contro
Autor:
Kirsten R. Bergmann, Michiel J. B. Kemme, Ulrik Svane Sørensen, Morten Grunnet, Erica S. Klaassen, Jacobus Burggraaf, Nils Edvardsson, Mahdi Saghari, Bo Hjorth Bentzen, Christina Sylvest, Jonas Goldin Diness, Pim Gal
Publikováno v:
Clinical and Translational Science
Gal, P, Klaassen, E S, Bergmann, K R, Saghari, M, Burggraaf, J, Kemme, M J B, Sylvest, C, Sørensen, U, Bentzen, B H, Grunnet, M, Diness, J G & Edvardsson, N 2020, ' First Clinical Study with AP30663-a K Ca 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation ', Clinical and Translational Science, vol. 13, no. 6, pp. 1336-1344 . https://doi.org/10.1111/cts.12835
Clinical and Translational Science, 13(6), 1336-1344. Wiley-Blackwell
Gal, P, Klaassen, E S, Bergmann, K R, Saghari, M, Burggraaf, J, Kemme, M J B, Sylvest, C, Sørensen, U, Bentzen, B H, Grunnet, M, Diness, J G & Edvardsson, N 2020, ' First Clinical Study with AP30663-a K Ca 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation ', Clinical and Translational Science, vol. 13, no. 6, pp. 1336-1344 . https://doi.org/10.1111/cts.12835
Clinical and Translational Science, 13(6), 1336-1344. Wiley-Blackwell
Pharmacological cardioversion of atrial fibrillation (AF) is frequently inefficacious. AP30663, a small conductance Ca2+ activated K+ (KCa2) channel blocker, prolonged the atrial effective refractory period in preclinical studies and subsequently con
Publikováno v:
Br J Clin Pharmacol
With this study, we aim to test the hypothesis that the effect of cannabidiol on drop-seizure frequency in patients with Lennox-Gastaut syndrome and Dravet syndrome could be attributed to a drug-drug interaction with clobazam. We performed clinical t
Autor:
Michiel J van Esdonk, Gijs W. E. Santen, Matthijs D. Kruizinga, Rob Zuiker, Adam F. Cohen, Kirsten R. Bergmann, Annelies C. Egas
Publikováno v:
British Journal of Clinical Pharmacology, 88(5), 2236-2245. WILEY
AIM Traditional studies focusing on the relationship between pharmacokinetics (PK) and pharmacodynamics necessitate blood draws which are too invasive for children or other vulnerable populations. A potential solution is to use non-invasive sampling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b12505200af976605b83abf1f1c0c3
https://hdl.handle.net/1887/3256858
https://hdl.handle.net/1887/3256858