Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Kirsten Nikolajsen"'
1
Antigen-Specific T-Cell Immunity in Multiple Myeloma Patients is Restored Following High-Dose Therapy: Implications for Timing of Vaccination
Autor: Hans Erik Johnsen, Inge Marie Svane, Kirsten Nikolajsen
Publikováno v: Svane, I M, Nikolajsen, K & Johnsen, H E 2007, ' Antigen-specific T-cell immunity in multiple myeloma patients is restored following high-dose therapy: implications for timing of vaccination. ', Scandinavian Journal of Immunology, vol. 66, no. 4, pp. 465-75 .
Aalborg University
The present study analyses the influence of high-dose chemotherapy (HD) and autologous stem cell transplantation on natural and vaccine induced specific immunity in multiple myeloma patients. Peripheral blood was collected from six multiple myeloma (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19424caf2a9c56e3168fa2997a78f60
https://doi.org/10.1111/j.1365-3083.2007.01993.x
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2
Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers
Autor: Eva Balslev, Anders Elm Pedersen, Svend Saalbach Ottesen, Julia S. Johansen, Kirsten Nikolajsen, Dorte Nielsen, Claus Kamby, Hans Erik Johnsen, Inge Marie Svane, Mogens H. Claesson, Eva Gaarsdal
Publikováno v: Cancer Immunology, Immunotherapy. 56:1485-1499
p53 mutations are found in up to 30% of breast cancers and peptides derived from over- expressed p53 protein are presented by class I HLA molecules and may act as tumor-associated epitopes in cancer vaccines. A dendritic cell (DC) based p53 tar- geti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77c9808543e1b2bffb0bb7d5d35cfa7
https://doi.org/10.1007/s00262-007-0293-4
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3
Phenotypic and Functional Characterization of Clinical Grade Dendritic Cells Generated from Patients with Advanced Breast Cancer for Therapeutic Vaccination
Autor: Søren Buus, Mette Thorn, Monika Gad, Hans Erik Johnsen, Kirsten Nikolajsen, Anders Elm Pedersen, Mark R. Walter, Eva Gaarsdal, Inge Marie Svane, Mogens H. Claesson
Publikováno v: Scandinavian Journal of Immunology. 61:147-156
Dendritic cells (DC) are promising candidates for cancer immunotherapy. However, it is not known whether in vitro-generated monocyte-derived DC from cancer patients are altered compared with DC from healthy donors. In a clinical phase I/II study, mon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e2dccece64f739ff10e0f3a11730f3
https://doi.org/10.1111/j.0300-9475.2005.01531.x
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4
Selective loss of progenitor subsets following clinical CD34+ cell enrichment by magnetic field, magnetic beads or chromatography separation
Autor: Kirsten Nikolajsen, H Andersen, Lars Stoumann Jensen, S W Hansen, Eva Gaarsdal, Lene Meldgaard Knudsen, E Taaning, E Kjaesgârd, Thomas Rasmussen, Martin Hutchings, Hans Erik Johnsen, Niels Ebbe Hansen
Publikováno v: Bone Marrow Transplantation. 24:1329-1336
In this preclinical evaluation we have compared the efficacy of three clinical CD34+enrichment procedures with respect to purity, yield and recovery, as well as risk of selective loss of CD34+ lineage-specific subsets. The three devices work by diffe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bada54abcadf99295886779436c27be
https://doi.org/10.1038/sj.bmt.1702077
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5
Validation of the Nordic Flow Cytometry Standard for CD34+ Cell Enumeration in Blood and Autografts: Report from the Third Workshop
Autor: Hans Erik Johnsen, Kirsten Nikolajsen, John Bæch
Publikováno v: Journal of Hematotherapy. 8:15-28
Following two workshops on standardization of enumeration of CD34+ cells in blood and leukapheresis products, the Nordic Stem Cell Laboratory Group (NSCL-G) evaluated the Milan/Mulhouse/Nordic standard in clinical practice during the third workshop (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d72ef014e3b7bc842f28e884315296f
https://doi.org/10.1089/106161299320532
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6
Depletion of T lymphocytes is correlated with response to temozolomide in melanoma patients
Autor: Marie Klinge Brimnes, Rikke Andersen, Lars Bastholt, Mads Hald Andersen, Inge Marie Svane, Kirsten Nikolajsen, Sine Reker Hadrup, Trine Zeeberg Iversen
Publikováno v: Iversen, T Z, Brimnes, M K, Nikolajsen, K, Hadrup, S R, Andersen, M H, Bastholt, L & Svane, I M 2013, ' Depletion of T lymphocytes is correlated with response to temozolomide in melanoma patients ', OncoImmunology, vol. 2, no. 2, E23288 . https://doi.org/10.4161/onci.23288
Oncoimmunology
Therapeutic strategies to deplete lymphocytes, especially regulatory T cells, in cancer patients have been proposed to increase the benefits of (immuno)chemotherapy. In this study, we explored the influence of temozolomide (TMZ) on different T-cell p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d8eb22e1c4b8b39cfa3cb9112758eb
https://portal.findresearcher.sdu.dk/da/publications/63de566d-6b6a-41a4-8b3b-9986b99320a2
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7
[Flowcytometric diagnostics of hereditary spherocytosis]
Autor: Caroline H, Riley, Kirsten, Nikolajsen, Erik, Kjaersgaard, Tobias Wirenfeldt, Klausen, Torben, Mourits-Andersen, Niels, Clausen, Birgitte, Lausen, Steen, Rosthøj, Henrik, Birgens
Publikováno v: Ugeskrift for laeger. 171(49)
The diagnosis of hereditary spherocytosis (HS) is based upon clinical presentation, typical laboratory findings of haemolysis with an increased mean corpuscular haemoglobin concentration (MCHC) combined with a positive osmotic fragility result. The d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09833bdb039db606ab3cd40e01064f53
https://pubmed.ncbi.nlm.nih.gov/19954702
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8
Alterations in p53-specific T cells and other lymphocyte subsets in breast cancer patients during vaccination with p53-peptide loaded dendritic cells and low-dose interleukin-2
Autor: Inge Marie Svane, Kirsten Nikolajsen, Anders Elm Pedersen, Mai-Britt Zocca
Publikováno v: Vaccine. 26(36)
We have previously established a cancer vaccine using autologous DCs, generated by in vitro stimulation with IL-4 and GM-CSF, and pulsed with six HLA-A*0201 binding wild-type p53 derived peptides. This vaccine was used in combination with low-dose in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcccebd611ca93cbf4175ceeb32043b
https://pubmed.ncbi.nlm.nih.gov/18616968
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10
Impact of high-dose chemotherapy on antigen-specific T cell immunity in breast cancer patients. Application of new flow cytometric method
Autor: Inge Marie Svane, Hans Erik Johnsen, Kirsten Nikolajsen, S W Hansen, Dorte Nielsen, Claus Kamby
Publikováno v: Bone marrow transplantation. 29(8)
The present study analyses the influence of high-dose chemotherapy (HD) and autologous stem cell transplantation on natural and vaccine-induced specific immunity in breast cancer patients. Peripheral blood was collected from five breast cancer patien
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706072ac3fb9a2b8808bbff83b0a97bd
https://pubmed.ncbi.nlm.nih.gov/12180110
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