Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kirsten M Stray"'
Autor:
Datsen George Wei, Vicki Chiang, Elizabeth Fyne, Mini Balakrishnan, Tiffany Barnes, Michael Graupe, Joseph Hesselgesser, Alivelu Irrinki, Jeffrey P Murry, George Stepan, Kirsten M Stray, Angela Tsai, Helen Yu, Jonathan Spindler, Mary Kearney, Celsa A Spina, Deborah McMahon, Jacob Lalezari, Derek Sloan, John Mellors, Romas Geleziunas, Tomas Cihlar
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004071 (2014)
Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation of HIV expression in latently infected cells is being explored as one of the strategies to d
Externí odkaz:
https://doaj.org/article/ac65303f63b846a6ab208ba464922569
Autor:
Mini Balakrishnan, Stephen R Yant, Luong Tsai, Christopher O'Sullivan, Rujuta A Bam, Angela Tsai, Anita Niedziela-Majka, Kirsten M Stray, Roman Sakowicz, Tomas Cihlar
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74163 (2013)
HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-transfer inhibitors (INSTIs) and ii) the non-catalytic site integrase inhibitors (NCINIs). NCINIs bind at the IN dimer interface and are thought to interfe
Externí odkaz:
https://doaj.org/article/ab7f85858d794836a0e3f22e87f9d8d3
Autor:
Michel Perron, Xiaofeng Zhao, Richard L. Mackman, Robert Jordan, Daniel Byun, Raju Subramanian, Tomas Cihlar, Kwon Soo Chun, Diane Lye, Christopher A. Palmiotti, Darius Babusis, Hui Hon Chung, Scott Simonovich, Bin Ma, Sarah Wortman, Lijun Zhang, Gary Lee, Julie Chan, Maria M. Toteva, Eisuke Murakami, Kirsten M. Stray, Xianghan Lu, Jared Pitts, Dustin Siegel, John P. Bilello, Kimberly T. Barrett, Bindu Goyal, Cynthia Kim, Arya Vijjapurapu, Venice Du Pont, Adelle Vandersteen
Publikováno v:
Journal of Medicinal Chemistry. 64:5001-5017
A discovery program targeting respiratory syncytial virus (RSV) identified C-nucleoside 4 (RSV A2 EC50 = 530 nM) as a phenotypic screening lead targeting the RSV RNA-dependent RNA polymerase (RdRp). Prodrug exploration resulted in the discovery of re
Autor:
Darius Babusis, Yeojin Park, Tomas Cihlar, Kirsten M. Stray, Michel Perron, Christian Callebaut, Adrian S. Ray
Publikováno v:
Antiviral Research. 140:116-120
HIV-infected patients treated with certain nucleoside reverse transcriptase inhibitors (NRTIs) have experienced adverse effects due to drug-related mitochondrial toxicity. Tenofovir alafenamide (TAF) is a novel prodrug of the NRTI tenofovir (TFV) wit
Autor:
Kirsten M. Stray, Tomas Cihlar, Michael I. Miller, Michel Perron, Jason W. Chien, Francisco Anderson, Sandra A Lewis, Jason K. Perry, Danielle P. Porter, John P. DeVincenzo, Robert Jordan
Publikováno v:
The Journal of infectious diseases. 222(9)
BackgroundPresatovir is an oral respiratory syncytial virus (RSV) fusion inhibitor targeting RSV F protein. In a double-blind, placebo-controlled study in healthy adults experimentally infected with RSV (Memphis-37b), presatovir significantly reduced
Autor:
Stuart T. Nichol, Brett P. Eaton, Nate Larson, Ginger Donnelly, Mike Flint, Robert Jordan, Douglas L. Mayers, Michel Perron, Yeojin Park, Dustin Siegel, Lydia Wolfe, Veronica Soloveva, Edward Doerffler, William A. Lee, Donald K. Nichols, Dima N. Gharaibeh, Elizabeth C. Grimes, Laura Gomba, Darius Babusis, Travis K. Warren, Kwon Soo Chun, Tomas Cihlar, Queenie Wang, Adrian S. Ray, Kirsten M. Stray, Bruce Ross, Elyse R. Nagle, Kelly S. Stuthman, Lisa S. Welch, Rachel Fearns, Jonathan E. Nuss, Willard Lew, Jeffrey R. Kugelman, Molly R. Braun, Roy Bannister, Richard L. Mackman, Pamela Wong, Christina F. Spiropoulou, Joy Y. Feng, Hui Hon Chung, Ona Barauskas, Sean Neville, Jay Wells, Robert G. Strickley, Catherine L. Wilhelmsen, S. Swaminathan, Iva Trancheva, Nicole L. Garza, Cary Retterer, Michael K. Lo, Sean A. Van Tongeren, Gustavo Palacios, Laura K. McMullan, Amy C. Shurtleff, Lijun Zhang, Michael O. Clarke, Yili Xu, Sina Bavari, Tara Kenny, Ernest Carra, Rouzbeh Zamani, Shan Shan Chen
Publikováno v:
Nature
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agen
Autor:
Pedro A. Piedra, Dorothy Agnes Theodore, Robert Jordan, Sangi Michael, Michel Perron, Kirsten M. Stray, Eugene J. Eisenberg, Richard L. Mackman, Brian E. Gilbert, Geoffery L. Toms, Gary Lee, April Kinkade, Tomas Cihlar
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:1264-1273
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and young children. In addition, RSV causes significant morbidity and mortality in hospitalized elderly and immunocompromised patients. Currently, o
Autor:
Rujuta A. Bam, Luong Tsai, Kirsten M. Stray, Madeleine Willkom, Gabriel Birkus, Tomas Cihlar, Christian R. Frey, Stephen R. Yant
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:316-322
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Previous studies suggested a principal role for the lysosomal serine protease cathepsin A (CatA) in the in
Autor:
Anne Carey, Kirsten M. Stray, Brian E. Gilbert, Pedro A. Piedra, Dorothy Agnes Theodore, Kerim Babaoglu, Jay P. Parrish, Manoj C. Desai, Lijun Zhang, April Kinkade, Hai Yang, Dharmaraj Samuel, Oliver L. Saunders, Constantine G. Boojamra, Jaclyn Hayes, Robert Jordan, Sangi Michael, Eugene J. Eisenberg, David Sperandio, Dustin Siegel, Richard L. Mackman, Hui Hon Chung, Quynh Iwata, Tomas Cihlar, Michel Perron, Gary Lee, Robert G. Strickley
Publikováno v:
Journal of Medicinal Chemistry. 58:1630-1643
GS-5806 is a novel, orally bioavailable RSV fusion inhibitor discovered following a lead optimization campaign on a screening hit. The oral absorption properties were optimized by converting to the pyrazolo[1,5-a]-pyrimidine heterocycle, while potenc
Autor:
Robert Jordan, Michael K. Lo, Sina Bavari, Robert G. Strickley, Michel Perron, Travis K. Warren, Ona Barauskas, Richard L. Mackman, Lijun Zhang, Sean Neville, Veronica Soloveva, Joy Y. Feng, Dustin Siegel, Willard Lew, Kwon Soo Chun, Adrian S. Ray, Kirsten M. Stray, Queenie Wang, Ernest Carra, Bruce Ross, Michael O'neil Hanrahan Clarke, Arnold L. Rheingold, Tomas Cihlar, John E. Knox, Yili Xu, William A. Lee, Roy Bannister, Lydia Wolfe, S. Swaminathan, Jason K. Perry, Hui Hon Chung, Gary Lee, Edward Doerffler
Publikováno v:
Journal of Medicinal Chemistry
The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history with over 28,000 cases, resulting in >11,000 deaths including >500 healthcare workers. A focused screening and lead optimization effort identified 4b (GS-5734)