Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kirsten L. Miller"'
Autor:
Kirsten L. Miller, Kagba N. Suaray
Publikováno v:
International Journal of Education in Mathematics, Science and Technology. 11:586-611
Placement and support of students in first-year mathematics courses at institutions of higher education has long been a consequential issue. In a bid to address it, many systems and institutions of higher learning have elected to implement a co-remed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1521b79b2f48a805c012eb466e83c33b
https://doi.org/10.46328/ijemst.2782
https://doi.org/10.46328/ijemst.2782
Autor:
Lisa Dvorak, Curt A. Dvorak, Curt Mazur, Kiev S. Ly, Michael Bogenstaetter, Jill A. Jablonowski, Brian Lord, Timothy W. Lovenberg, Jamin D. Boggs, Kirsten L. Miller, Nicholas I. Carruthers, Sandy J. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:903-907
A novel series of imidazole containing histamine H3 receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these compounds were found to have no app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c13fe402ebda266c7b30dd1d778341d
https://doi.org/10.1016/j.bmcl.2008.11.114
https://doi.org/10.1016/j.bmcl.2008.11.114
Autor:
Xiaohui Jiang, Kirsten L. Miller, Emily M. Stocking, Lisa Dvorak, Nicholas I. Carruthers, Jamin D. Boggs, Kiev S. Ly, Sandy J. Wilson, Brian Lord, Michael A. Letavic, Diane Nepomuceno, Jennifer M. Miller, John M. Keith, Pascal Bonaventure, Ann J. Barbier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:39-43
The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H 3 ligands and serotonin reuptake inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe46c5609bba379abad9abe531ad4b8
https://doi.org/10.1016/j.bmcl.2007.11.016
https://doi.org/10.1016/j.bmcl.2007.11.016
Autor:
Kiev S. Ly, John M. Keith, Carsten Schubert, Jiejun Wu, Michael A. Letavic, Ann J. Barbier, Sandy J. Wilson, Marta C. Abad, Brian Lord, Heather McAllister, Kirsten L. Miller, Nicholas I. Carruthers, Emily M. Stocking, D.J. Tognarelli, Jill A. Jablonowski, Timothy W. Lovenberg, Leslie A. Gomez, Pascal Bonaventure, Jamin D. Boggs, Jennifer M. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1047-1051
A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18387593a9ce978641ff4e2bca48f8a
https://doi.org/10.1016/j.bmcl.2006.11.036
https://doi.org/10.1016/j.bmcl.2006.11.036
Autor:
Curt A. Dvorak, Richard Apodaca, Pascal Bonaventure, Kirsten L. Miller, Christine Dugovic, Lisa Dvorak, Jonathan Shelton, Wei Xiao, Jill A. Jablonowski, Brian Lord, Timothy W. Lovenberg, Nicholas I. Carruthers
Publikováno v:
European journal of medicinal chemistry. 44(10)
A series of (4-aminobutyn-1-yl)benzylamines were prepared and the SAR around three key areas: (1) the amine attached to the butynyl linker (R(3)R(4)N-); (2) the benzylamine moiety (R(1)R(2)N-); and (3) the point of attachment of the benzylamine group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb71b95f5f4c91478bc306d7fb3e2bba
https://pubmed.ncbi.nlm.nih.gov/19524331
https://pubmed.ncbi.nlm.nih.gov/19524331
Autor:
Kirsten L. Miller, Michael A. Letavic, Diane Nepomuceno, Pascal Bonaventure, Brian Lord, Kiev S. Ly, John M. Keith, Nicholas I. Carruthers, S. Timothy Motley, Steven W. Sutton, Mark A. Feinstein
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(21)
The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H 3 antagonists is described. The new compounds are high affinity histamine H 3 ligands that penetrate the CNS and occupy the histamine H 3 receptor in rat b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd19ccd5a4b70ad5040aaa25493538d
https://pubmed.ncbi.nlm.nih.gov/18922693
https://pubmed.ncbi.nlm.nih.gov/18922693
Publikováno v:
Behavioural pharmacology. 19(2)
5-HT7 receptors have been linked to a number of psychiatric disorders including anxiety and depression. The localization of 5-HT7 receptors in the thalamus, a key sensory processing center, and the high affinity of many atypical antipsychotic compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e72cb0ba1ffffff4cb63884f7cf6406
https://pubmed.ncbi.nlm.nih.gov/18332680
https://pubmed.ncbi.nlm.nih.gov/18332680
Autor:
Dale A. Rudolph, Curt A. Dvorak, Brock T. Shireman, Timothy W. Lovenberg, Nicholas I. Carruthers, Diane Nepomuceno, Pascal Bonaventure, Lisa Dvorak, Kirsten L. Miller
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(6)
The synthesis and SAR for a novel series of 2-alkyl-4-aryl-tetrahydro-pyrido-pyrimidines and 2-alkyl-4-aryl-tetrahydro-pyrimido-azepines is described. Representative compounds were shown to be subtype selective 5-HT(2A) antagonists. Optimal placement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5b08e76d0dcc0abf4eb398ac2372c7
https://pubmed.ncbi.nlm.nih.gov/18282705
https://pubmed.ncbi.nlm.nih.gov/18282705
Autor:
Kirsten L. Miller, Scott D. Bembenek, Leah Aluisio, Nicholas I. Carruthers, Richard Apodaca, Timothy W. Lovenberg, Lisa Dvorak, Ann J. Barbier, Michael A. Letavic, John M. Keith
Publikováno v:
Bioorganicmedicinal chemistry. 16(6)
Currently, the only clinically effective treatment for Alzheimer's disease (AD) is the use of acetylcholinesterase (AChE) inhibitors. These inhibitors have limited efficacy in that they only treat the symptoms and not the disease itself. Additionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a107e2495b6076cd8af2d750db1aefc1
https://pubmed.ncbi.nlm.nih.gov/18249544
https://pubmed.ncbi.nlm.nih.gov/18249544
Autor:
Brian Lord, Jamin D. Boggs, Sandy J. Wilson, Kirsten L. Miller, Michael A. Letavic, Emily M. Stocking, Nicholas I. Carruthers, Ann J. Barbier, Pascal Bonaventure
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(17)
The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H3 ligands that are also serotonin reuptake transporters is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d9e103c4c5719360a2e6fcdaf7d445
https://pubmed.ncbi.nlm.nih.gov/17616397
https://pubmed.ncbi.nlm.nih.gov/17616397