Single-cell quantitative bioimaging of P. berghei liver stage translation

Autor: James L. McLellan, William Sausman, Ashley B. Reers, Evelien M. Bunnik, Kirsten K. Hanson

Publikováno v: mSphere, Vol 8, Iss 6 (2023)

ABSTRACTPlasmodium parasite resistance to existing antimalarial drugs poses a devastating threat to the lives of many who depend on their efficacy. New antimalarial drugs and novel drug targets are in critical need, along with novel assays to acceler

Externí odkaz: https://doaj.org/article/09a36f86aef54b9eb0e652d9f45e4ab8

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

Autor: Christine S Hopp, Brandy L Bennett, Satish Mishra, Christine Lehmann, Kirsten K Hanson, Jing-Wen Lin, Kimberly Rousseau, Filomena A Carvalho, Wouter A van der Linden, Nuno C Santos, Matthew Bogyo, Shahid M Khan, Volker Heussler, Photini Sinnis

Publikováno v: PLoS Pathogens, Vol 13, Iss 9, p e1006586 (2017)

Proteases have been implicated in a variety of developmental processes during the malaria parasite lifecycle. In particular, invasion and egress of the parasite from the infected hepatocyte and erythrocyte, critically depend on protease activity. Alt

Externí odkaz: https://doaj.org/article/89689e3f69b94011b1a32244742d0945

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Autor: Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis

Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005763 (2016)

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg

Externí odkaz: https://doaj.org/article/18b88a00726d44659ebd19c6f7c84d1b

Design of proteasome inhibitors with oral efficacy in vivo against

Autor: Stanley C, Xie, Riley D, Metcalfe, Hirotake, Mizutani, Tanya, Puhalovich, Eric, Hanssen, Craig J, Morton, Yawei, Du, Con, Dogovski, Shih-Chung, Huang, Jeffrey, Ciavarri, Paul, Hales, Robert J, Griffin, Lawrence H, Cohen, Bei-Ching, Chuang, Sergio, Wittlin, Ioanna, Deni, Tomas, Yeo, Kurt E, Ward, Daniel C, Barry, Boyin, Liu, David L, Gillett, Benigno F, Crespo-Fernandez, Sabine, Ottilie, Nimisha, Mittal, Alisje, Churchyard, Daniel, Ferguson, Anna Caroline C, Aguiar, Rafael V C, Guido, Jake, Baum, Kirsten K, Hanson, Elizabeth A, Winzeler, Francisco-Javier, Gamo, David A, Fidock, Delphine, Baud, Michael W, Parker, Stephen, Brand, Lawrence R, Dick, Michael D W, Griffin, Alexandra E, Gould, Leann, Tilley

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Here, we describe inhibitors of the Plasmodium proteasome, an enzymatic complex that malaria parasites rely on to degrade proteins. Starting from inhibitors developed to treat cancer, derivatives were designed and synthesized with the ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a17d17dad9983ee3c287198b34e727b8
https://pubmed.ncbi.nlm.nih.gov/34548400

Striatin is a novel modulator of cell adhesion

Autor: Ilse Hofmann, Lital Lahav-Ariel, Michal Caspi, Prathamesh T Nadar-Ponniah, Werner W. Franke, Kirsten K. Hanson, Ella H. Sklan, Rina Rosin-Arbesfeld, Natalie Zelikson, Karen B. Avraham

The adherens junctions (AJs) and tight junctions (TJs) provide critical adhesive contacts between neighboring epithelial cells and are crucial for epithelial adhesion, integrity, and barrier functions in a wide variety of tissues and organisms. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f6ef9b23c1dceacefbcefffe9e50f1
https://europepmc.org/articles/PMC6988865/