Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Kirsten H. Limesand"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Salivary glands are indirectly damaged during radiotherapy for head and neck cancer, resulting in acute and chronic hyposalivation. Current treatments for radiation-induced hyposalivation do not permanently restore function to the gland; the
Externí odkaz:
https://doaj.org/article/3b6bf634877f411fbfa1fe45da06e88c
Autor:
Jordan A. Gunning, Kristy E. Gilman, Tiffany M. Zúñiga, Richard J. Simpson, Kirsten H. Limesand
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/cf8f374c5f3d436abd0c703890cea6a6
Autor:
Brenna A. Rheinheimer, Mary C. Pasquale, Kirsten H. Limesand, Matthew P. Hoffman, Alejandro M. Chibly
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106660- (2023)
Summary: Understanding the transcriptional landscape that results in chronic salivary hypofunction after irradiation will help identify injury mechanisms and develop regenerative therapies. We present scRNA-seq analysis from control and irradiated mu
Externí odkaz:
https://doaj.org/article/f4994bd5e8e9474da7d59249fce31b94
Autor:
Lauren G. Buss, Diogo De Oliveira Pessoa, Justin M. Snider, Megha Padi, Jessica A. Martinez, Kirsten H. Limesand
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/e3f89e786cf745a3b259f87f0208c73d
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Annually, >600,000 new cases of head and neck cancer (HNC) are diagnosed worldwide with primary treatment being surgery and radiotherapy. During ionizing radiation (IR) treatment of HNC, healthy salivary glands are collaterally damaged, leading to lo
Externí odkaz:
https://doaj.org/article/efc8c7ac00d94c15859f49c99f662b1d
Autor:
Mahmoud G. Khalafalla, Lucas T. Woods, Kimberly J. Jasmer, Kevin Muñoz Forti, Jean M. Camden, Janicke L. Jensen, Kirsten H. Limesand, Hilde K. Galtung, Gary A. Weisman
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel. Therefore, saliv
Externí odkaz:
https://doaj.org/article/a2dca1737cb34136b4dfa4310d80b2cd
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3304 (2020)
As an essential nutrient, manganese is required for the regulation of numerous cellular processes, including cell growth, neuronal health, immune cell function, and antioxidant defense. However, excess manganese in the body is toxic and produces symp
Externí odkaz:
https://doaj.org/article/8013a18216ce45d9a6d4d41cd73ac737
Publikováno v:
Cellular Oncology, Vol 30, Iss 5, Pp 371-387 (2008)
Dacarbazine (DTIC) has been used for the treatment of melanoma for decades. However, monotherapy with this chemotherapeutic agent results only in moderate response rates. To improve tumor response to DTIC current clinical trials in melanoma focus on
Externí odkaz:
https://doaj.org/article/cd6144c9c78741e78e1b53a16a215e2b
Autor:
Lauren G Buss, Diogo De Oliveira Pessoa, Justin M Snider, Megha Padi, Jessica A Martinez, Kirsten H Limesand
Salivary gland hypofunction is an adverse side effect associated with radiotherapy for head and neck cancer patients. This study delineated metabolic changes at acute, intermediate, and chronic radiation damage response stages in mouse salivary gland
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1402f5968c31f926e91de3e7ad79fc1b
Autor:
Lauren G Buss, Kirsten H Limesand
The salivary gland is a nearby organ in head and neck cancer patients that is damaged by radiation treatment, resulting in hyposalivation and xerostomia. Current treatments for radiation-induced hyposalivation are temporary and do not permanently res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7074958399d28d425fd066711105af42