Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers with low mutational burden

Autor: Sunil Kumar Saini, Andreas Due Ørskov, Anne-Mette Bjerregaard, Ashwin Unnikrishnam, Staffan Holmberg-Thyden, Annie Borch, Govardhan Anande, Amalie Bentzen, Andrea Marquard, Tripti Tamhane, Anne Gang, Inge Defva, Zoltan Szallasi, Aron Eklund, John Pimanda, Kirsten Gronbaek, Sine Hadrup

Publikováno v: Technical University of Denmark Orbit
University of Copenhagen

Human endogenous retroviruses (HERVs) form a substantial part of the human genome. However, most elements remain transcriptionally silent. Malignant transformation and epigenetic therapies may induce transcription of HERV elements. Such HERV elements

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47583d84a83e211631b30494e54a97ca
https://orbit.dtu.dk/en/publications/78a1758c-6fb0-454d-ab9a-44f71b14df29

Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients:A rationale for combined targeting of PD-1 and DNA methylation

Autor: Marianne Bach Treppendahl, Anni Skovbo, Andreas Due Ørskov, Lone S. Friis, Mette Holm, Marianne Hokland, Kirsten Grønbæk

Publikováno v: Ørskov, A D, Treppendahl, M B, Skovbo, A, Holm, M S, Friis, L S, Hokland, M & Grønbæk, K 2015, ' Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients : A rationale for combined targeting of PD-1 and DNA methylation ', OncoTarget, vol. 6, no. 11, pp. 9612-26 . https://doi.org/10.18632/oncotarget.3324
Scopus-Elsevier
Ørskov, A D, Treppendahl, M B, Skovbo, A, Holm, M S, Friis, L S, Hokland, M & Gronbaek, K 2015, ' Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients : A rationale for combined targeting of PD-1 and DNA methylation ', OncoTarget, vol. 6, no. 11, pp. 9612-9626 . https://doi.org/10.18632/oncotarget.3324
Oncotarget

// Andreas D. Orskov 1, * , Marianne B. Treppendahl 1, * , Anni Skovbo 2, 3 , Mette S. Holm 4 , Lone S. Friis 1, 5 , Marianne Hokland 2 , Kirsten Gronbaek 1 1 Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec2a1122daad8268bf08082b083d01d
https://pure.au.dk/portal/da/publications/hypomethylation-and-upregulation-of-pd1-in-t-cells-by-azacytidine-in-mdsaml-patients(9d16c417-e88f-44b0-846b-8534ad5d0de3).html

Reports on Mantle Cell Lymphoma from Lund University Provide New Insights (Overexpression of the Key Metabolic Protein Cpt1a Defines Mantle Cell Lymphoma Patients With Poor Response To Standard High-dose Chemotherapy Independent of Mipi and...).

Publikováno v: Hematology Week; 7/3/2023, p1724-1724, 1p

Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins.

Autor: Soerensen, Mette, Tulstrup, Morten, Hansen, Jakob Werner, Weischenfeldt, Joachim, Gronbaek, Kirsten, Christensen, Kaare

Publikováno v: HemaSphere; Sep2022, Vol. 6 Issue 9, pe768-e768, 1p

Onco-miR-155 targets SHIP1 to promote TNFα-dependent growth of B cell lymphomas.

Autor: Pedersen, Irene M., Otero, Dennis, Kao, Elaine, Miletic, Ana V., Hother, Christoffer, Ralfkiaer, Elisabeth, Rickert, Robert C., Gronbaek, Kirsten, David, Michael

Publikováno v: EMBO Molecular Medicine; Aug2009, Vol. 1 Issue 5, p288-295, 8p