Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kirsten Gillingwater"'
Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification
Autor:
Marina C. Perieteanu, Leah M. C. McGee, Craig D. Shaw, Donna S. MacMillan, Abedawn I. Khalaf, Kirsten Gillingwater, Rebecca Beveridge, Katharine C. Carter, Colin J. Suckling, Fraser J. Scott
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11912 (2022)
The neglected tropical disease leishmaniasis, caused by Leishmania spp., is becoming more problematic due to the emergence of drug-resistant strains. Therefore, new drugs to treat leishmaniasis, with novel mechanisms of action, are urgently required.
Externí odkaz:
https://doaj.org/article/dfb9f42b7d064da89f760231f1a2e658
Autor:
Lori Ferrins, Amrita Sharma, Sarah M Thomas, Naimee Mehta, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Kirsten Gillingwater, Michael P Pollastri
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006834 (2018)
We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent c
Externí odkaz:
https://doaj.org/article/7cdba245bb1545f0a3fa0706ebb2f1b2
Autor:
Daniela Begolo, Isabel M Vincent, Federica Giordani, Ina Pöhner, Michael J Witty, Timothy G Rowan, Zakaria Bengaly, Kirsten Gillingwater, Yvonne Freund, Rebecca C Wade, Michael P Barrett, Christine Clayton
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007315 (2018)
Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential
Externí odkaz:
https://doaj.org/article/e1674f3ac3f24f8baaf483e779b5f349
Autor:
Kirsten Gillingwater, Carlos Gutierrez, Arlene Bridges, Huali Wu, Stijn Deborggraeve, Rosine Ali Ekangu, Arvind Kumar, Mohamed Ismail, David Boykin, Reto Brun
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20836 (2011)
Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of these compounds were additionally carried out. Goats
Externí odkaz:
https://doaj.org/article/2e6941434eff422b983015e36822cc05
Autor:
Fraser J. Scott, Abedawn I. Khalaf, C. D. Shaw, Jasmine M. Cross, Colin J. Suckling, Kirsten Gillingwater, Craig Irving, Katharine C. Carter, Michael P. Barrett, Federica Giordani, Daniel P. Brooke, Leah M. C. McGee
Publikováno v:
RSC Medicinal Chemistry
This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine. S-MGBs have been found to be act
Autor:
Alasdair Smith, Richard J. Wall, Stephen Patterson, Tim Rowan, Eva Rico Vidal, Laste Stojanovski, Margaret Huggett, Shahienaz E. Hampton, Michael G. Thomas, Victoriano Corpas Lopez, Kirsten Gillingwater, Jeff Duke, Grant Napier, Rose Peter, Hervé S. Vitouley, Justin R. Harrison, Rachel Milne, Laura Jeacock, Nicola Baker, Susan H. Davis, Frederick Simeons, Jennifer Riley, David Horn, Reto Brun, Fabio Zuccotto, Michael J Witty, Susan Wyllie, Kevin D. Read, Ian H. Gilbert
Publikováno v:
Journal of medicinal chemistry. 65(7)
African animal trypanosomiasis or nagana, caused principally by infection of the protozoan parasites
Autor:
Pilar Manzano, Maria Santos Martinez-Martinez, Miguel Navarro, Michael P. Pollastri, Naresh Gunaganti, Gloria Ceballos-Pérez, Kirsten Gillingwater, Domingo I. Rojas-Barros, Rosario Diaz-Gonzalez, Baljinder Singh
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
J Med Chem
instname
J Med Chem
Human African trypanosomiasis (HAT), or sleeping sickness, is caused by the protozoan parasite Trypanosoma brucei and transmitted through the bite of infected tsetse flies. The disease is considered fatal if left untreated. To identify new chemotypes
Autor:
Katharine C. Carter, Michael P. Barrett, Leah M. C. McGee, Federica Giordani, Colin J. Suckling, Daniel P. Brooke, C. D. Shaw, Fraser Scott, Craig Irving, Abedawn I. Khalaf, Kirsten Gillingwater, Jasmine M. Cross
Publikováno v:
RSC Medicinal Chemistry
This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine. S-MGBs have been found to be act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd348507ccd65886b47a705c7be99d4
https://edoc.unibas.ch/91407/
https://edoc.unibas.ch/91407/
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 2, Pp 159-164 (2018)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses. Two dr
Autor:
Kirsten Gillingwater, Harry P. de Koning, Abedawn I. Khalaf, Michael P. Barrett, Fraser Scott, Colin J. Suckling, Federica Giordani, Jane C. Munday
Publikováno v:
Journal of Medicinal Chemistry. 64:18236-18236