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pro vyhledávání: '"Kirsten E. H. Wiesmann"'
Autor:
Peter F. Leadlay, Kirsten E. H. Wiesmann, Jesus Cortes, Annabel L. Cutter, Murray J. B. Brown, James Staunton
Publikováno v:
Chemistry & Biology. 2:583-589
Background: The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea , which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated
Autor:
Gareth A. Roberts, Jesus Cortes, Murray J. B. Brown, Peter F. Leadlay, Kirsten E. H. Wiesmann, James Staunton
Publikováno v:
Science. 268:1487-1489
Macrocyclic polyketides exhibit an impressive range of medically useful activities, and there is great interest in manipulating the genes that govern their synthesis. The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which sy