Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kirsten E. Garka"'
Autor:
Blair R. Renshaw, Teresa L. Born, Kirsten E. Garka, Jeanette S. Bertles, John E. Sims, Dirk E. Smith
Publikováno v:
Journal of Biological Chemistry. 275:29946-29954
Two novel members of the interleukin-1 receptor (IL-1R) family, identified by homology searches of human genomic sequence data bases, are described. The genes have been named according to their structural features: TIGIRR-1(three immunoglobulin domai
Autor:
David A. Largaespada, Brian C. Gliniak, Philip J. Morrissey, John E. Sims, Neal G. Copeland, Unja Martin, Werner Müller, Andrew G. Farr, James P. Di Santo, Raymond J. Paxton, Nancy A. Jenkins, Kirsten E. Garka, Linda S. Park, Steven F. Ziegler
Publikováno v:
The Journal of Experimental Medicine
The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA
Autor:
John E. Sims, Patricia Parnet, Timothy P. Bonnert, Kirsten E. Garka, Joseph R. Testa, Gonosuke Sonoda
Publikováno v:
FEBS Letters. 402:81-84
Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to 'death-domains', is rapidly upregulated during differentiation of the myeloleukemic cell line M1. We have cloned the human homologue of murine MyD88 and re-
Autor:
Teresa L. Born, Dirk E. Smith, Kirsten E. Garka, Blair R. Renshaw, Jeanette S. Bertles, John E. Sims
Publikováno v:
Journal of Biological Chemistry. 275:41528-41530
Publikováno v:
The Journal of biological chemistry. 279(14)
Interleukin 1 (IL-1) plays a prominent role in immune and inflammatory reactions. Our understanding of the IL-1 family has recently expanded to include six novel members named IL-1F5 to IL-1F10. Recently, it was reported that IL-1F9 activated NF-kapp
Publikováno v:
Genomics. 79(5)
Recent additions have expanded the interleukin (IL)-1 gene family to 10 members. We have determined the order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2. We report cDNA sequences for the mouse o
Autor:
Pamela M. Holland, Charles Rauch, John E. Sims, Kirsten E. Garka, G. Duke Virca, Richard S. Johnson, Alison Milne, Timothy A. Bird, Cynthia R. Willis
Publikováno v:
The Journal of biological chemistry. 277(18)
We describe the isolation, cloning, and characterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate substrate Bicd2. Nek8 was isolated as a beta-casein kinase activity in rabbit lung and has an N-terminal catalytic domain h
Autor:
Neal G. Copeland, Sherree L. Friend, Kirsten E. Garka, Diane Foxworthe, Mary A. Bedell, Virginia L. Price, Douglas E. Williams, Philip J. Morrissey, John E. Sims, Raymond J. Paxton, Kenneth H. Grabstein, Andrew G. Farr, Nancy A. Jenkins
Publikováno v:
The Journal of Experimental Medicine
Using a bioassay consisting of the proliferation of a murine B cell line, a cDNA of a gene whose product supports the growth of that cell line was isolated from a thymic stromal cell line. This factor, termed thymic stromal lymphopoietin (TSLP), is a
Autor:
Dirk E. Smith, Marek Kubin, John E. Sims, Blair R. Renshaw, Kirsten E. Garka, Randal R. Ketchem
Publikováno v:
The Journal of biological chemistry. 275(2)
We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similari
Autor:
Steven K. Dower, John E. Sims, Mary Gerhart, Timothy P. Bonnert, Jennifer L. Mitcham, Jennifer L. Slack, Patricia Parnet, Margit A. Gayle, Kirsten E. Garka
Publikováno v:
The Journal of biological chemistry. 271(10)
Through data base searches, we have discovered new proteins that share homology with the signaling domain of the type I interleukin-1 receptor (IL-1RI): human "randomly sequenced cDNA 786" (rsc786), murine MyD88, and two partial Drosophila open readi