Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kirsten E. Erger"'
Autor:
Ingeborg M. Langohr, Dodd G. Sledge, Joshua T. Bartoe, András M. Komáromy, Thomas J. Conlon, Simon M. Petersen-Jones, Ryan F. Boyd, Sanford L. Boye, William W. Hauswirth, Shannon E. Boye, Kirsten E. Erger
Publikováno v:
Gene Therapy. 23:548-556
Adeno-associated virus (AAV) vector-based gene therapy is a promising treatment strategy for delivery of neurotrophic transgenes to retinal ganglion cells (RGCs) in glaucoma patients. Retinal distribution of transgene expression following intravitrea
Autor:
Rui Hou, Kirsten E. Erger, David G. Birch, Wenqiu Wang, Fowzan S. Alkuraya, William W. Hauswirth, Matthew M. LaVail, Douglas Vollrath, Fahad Al Saikhan, Hisham Alkuraya, Christopher Chung, Hassan Al-Dhibi, Nicola G. Ghazi, Thomas J. Conlon, Huimin Cai, Sanford L. Boye, Dilek Colak, Sawsan R. Nowilaty, Abdulrahman Al-Maghamsi, Wen-Tao Deng, Abdulrahman Alhommadi, Kang Zhang, Emad B. Abboud
Publikováno v:
Human Genetics. 135:327-343
MERTK is an essential component of the signaling network that controls phagocytosis in retinal pigment epithelium (RPE), the loss of which results in photoreceptor degeneration. Previous proof-of-concept studies have demonstrated the efficacy of gene
Autor:
Kirsten E. Erger, Alok K. Sharma, Thomas J. Conlon, Jeffrey D. Chulay, Guo-jie Ye, David R. Knop, Peter Sonnentag, Kellie Howard
Publikováno v:
Human Gene Therapy Clinical Development. 26:177-184
Applied Genetic Technologies Corporation is developing a recombinant adeno-associated virus (rAAV) vector for treatment of X-linked retinoschisis (XLRS), an inherited retinal disease characterized by splitting (schisis) of the layers of the retina, w
Autor:
Thomas J. Conlon, Kirsten E. Erger, Alfred S. Lewin, Sanford L. Boye, William W. Hauswirth, Rajeshwari D. Koilkonda, Vittorio Porciatti, Martha Neuringer, Carol Detrisac, Lauren Renner, Venu Talla, Hong Yu, William J. Feuer, John Guy, Vince A. Chiodo
Publikováno v:
Investigative Ophthalmology & Visual Science. 55:7739-7753
Purpose To demonstrate safety and efficacy of allotopic human ND4 for treatment of a Leber's hereditary optic neuropathy (LHON) mouse model harboring the G11778A mitochondrial mutation. Methods We induced LHON in mice by intravitreal injection of mut
Autor:
Hsin-Yin Tsai, Takashi Hamazaki, Naohiro Terada, Thomas J. Conlon, Arun Srivastava, William W. Hauswirth, Ahmed S. Elshikha, Kirsten E. Erger, Sihong Song, Mong-Jen Chen, Mark L. Brantly, Vince A. Chiodo, Hong Li, Chunli Yao, Yuanqing Lu
Publikováno v:
Human Gene Therapy Methods. 25:72-82
Induced pluripotent stem (iPS) cells have great potential for personalized regenerative medicine. Although several different methods for generating iPS cells have been reported, improvement of safety and efficiency is imperative. In this study, we te
Autor:
Kenneth E. Lamb, I. Sosa-Samper, Amara H. Estrada, Thomas J. Conlon, Brandy D. Mincey, Herbert W. Maisenbacher, B. Pogue, Kirsten E. Erger
Publikováno v:
Journal of Small Animal Practice. 54:361-366
Objective To evaluate retrograde coronary venous stem-cell delivery for Dobermanns with dilated cardiomyopathy. Methods Retrograde coronary venous delivery of adipose-derived mesenchymal stem cells transduced with tyrosine mutant adeno-associated vir
Publikováno v:
American journal of veterinary research. 77(2)
OBJECTIVE To compare mitochondrial oxygen consumption rate (OCR) of fibroblasts from Doberman Pinschers with and without dilated cardiomyopathy (DCM) and mutation of the gene for pyruvate dehydrogenase kinase isozyme 4 (PDK4) and to evaluate in vitro
Autor:
Vince A. Chiodo, Mark E. Clark, Shannon E. Boye, Christopher A. Girkin, Kristen J. Sandefer, Thomas J. Conlon, Kirsten E. Erger, Renee C. Ryals, Paul D. Gamlin, Witherspoon Cd, William W. Hauswirth, John J. Alexander, Sanford L. Boye, Jingfen Sun
Publikováno v:
Human Gene Therapy. 23:1101-1115
Adeno-associated virus (AAV) has proven an effective gene delivery vehicle for the treatment of retinal disease. Ongoing clinical trials using a serotype 2 AAV vector to express RPE65 in the retinal pigment epithelium have proven safe and effective.
Autor:
Cathryn Mah, Clive Wasserfall, Stacy Porvasnik, Annette Mach, Irene Zolotukhin, Thomas J. Conlon, Lisa R. Dixon, Martha Campbell-Thompson, Amy J. Wright, Steven Polyak, Andres Acosta, Kirsten E. Erger
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G296-G308
Effective gene transfer with sustained gene expression is an important adjunct to the study of intestinal inflammation and future therapy in inflammatory bowel disease. Recombinant adeno-associated virus (AAV) vectors are ideal for gene transfer and
Autor:
J.P. Verstegen, Janice Y. Chou, Thomas J. Conlon, Barry J. Byrne, Kirsten E. Erger, Catherine E. Correia, Cathryn Mah, Travis Cossette, David A. Weinstein, Laurie M. Fiske, Young Mok Lee, Andrew Specht, Maggie B. Struck, Martha Campbell-Thompson
Publikováno v:
Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2011 (2011)
Journal of Biomedicine and Biotechnology, Vol 2011 (2011)
A canine model of Glycogen storage disease type Ia (GSDIa) is described. Affected dogs are homozygous for a previously described M121I mutation resulting in a deficiency of glucose-6-phosphatase-α. Metabolic, clinicopathologic, pathologic, and clini