Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Kirsten E Lyke"'
Autor:
Kieran Tebben, Salif Yirampo, Drissa Coulibaly, Abdoulaye K Koné, Matthew B Laurens, Emily M Stucke, Ahmadou Dembélé, Youssouf Tolo, Karim Traoré, Amadou Niangaly, Andrea A Berry, Bourema Kouriba, Christopher V Plowe, Ogobara K Doumbo, Kirsten E Lyke, Shannon Takala-Harrison, Mahamadou A Thera, Mark A Travassos, David Serre
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0010802 (2023)
Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum and P. ovale are endemic to Mali and cause clinical malaria, with P. falciparum infections typically being more severe. Here, we sequenced RN
Externí odkaz:
https://doaj.org/article/4d89c16db384442da49ce0b6b3e281ca
Autor:
D Herbert Opi, Olivia Swann, Alexander Macharia, Sophie Uyoga, Gavin Band, Carolyne M Ndila, Ewen M Harrison, Mahamadou A Thera, Abdoulaye K Kone, Dapa A Diallo, Ogobara K Doumbo, Kirsten E Lyke, Christopher V Plowe, Joann M Moulds, Mohammed Shebbe, Neema Mturi, Norbert Peshu, Kathryn Maitland, Ahmed Raza, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N Williams, J Alexandra Rowe
Publikováno v:
eLife, Vol 7 (2018)
Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, consistent with
Externí odkaz:
https://doaj.org/article/edf04747e72c4233ba6dfb7dbeacb907
Autor:
Charles Arama, Issa Diarra, Bourèma Kouriba, Francine Sirois, Olesya Fedoryak, Mahamadou A Thera, Drissa Coulibaly, Kirsten E Lyke, Christopher V Plowe, Michel Chrétien, Ogobara K Doumbo, Majambu Mbikay
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192850 (2018)
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a hepatic secretory protein which promotes the degradation of low-density lipoprotein receptors leading to reduced hepatic uptake of plasma cholesterol. Non-synonymous single-nucleotide polymor
Externí odkaz:
https://doaj.org/article/ae3cf6debce24b37b278e53c0f7935ae
Autor:
Matthew B Laurens, Mahamadou A Thera, Drissa Coulibaly, Amed Ouattara, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Idrissa Traore, Bourema Kouriba, Dapa A Diallo, Issa Diarra, Modibo Daou, Amagana Dolo, Youssouf Tolo, Mahamadou S Sissoko, Amadou Niangaly, Mady Sissoko, Shannon Takala-Harrison, Kirsten E Lyke, Yukun Wu, William C Blackwelder, Olivier Godeaux, Johan Vekemans, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, Tina Dube, Lorraine Soisson, Carter L Diggs, Brent House, Jason W Bennett, David E Lanar, Sheetij Dutta, D Gray Heppner, Christopher V Plowe, Ogobara K Doumbo
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79323 (2013)
The FMP2.1/AS02A candidate malaria vaccine was tested in a Phase 2 study in Mali. Based on results from the first eight months of follow-up, the vaccine appeared well-tolerated and immunogenic. It had no significant efficacy based on the primary endp
Externí odkaz:
https://doaj.org/article/f3e7f0ed2aed4ebb916e5715672cdd1e
Autor:
Matthew B Laurens, Peter Billingsley, Adam Richman, Abraham G Eappen, Matthew Adams, Tao Li, Sumana Chakravarty, Anusha Gunasekera, Christopher G Jacob, B Kim Lee Sim, Robert Edelman, Christopher V Plowe, Stephen L Hoffman, Kirsten E Lyke
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68969 (2013)
Controlled human malaria infection (CHMI) is a powerful method for assessing the efficacy of anti-malaria vaccines and drugs targeting pre-erythrocytic and erythrocytic stages of the parasite. CHMI has heretofore required the bites of 5 Plasmodium fa
Externí odkaz:
https://doaj.org/article/1d6a599bd0e248e699f3289e20aa2ba1
Autor:
Kirsten E Lyke, Abdoulaye Dabo, Charles Arama, Modibo Daou, Issa Diarra, Amy Wang, Christopher V Plowe, Ogobara K Doumbo, Marcelo B Sztein
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31647 (2012)
Regulatory T cells (Tregs) suppress host immune responses and participate in immune homeostasis. In co-infection, secondary parasite infections may disrupt the immunologic responses induced by a pre-existing parasitic infection. We previously demonst
Externí odkaz:
https://doaj.org/article/2a3c25cc7fbb4557a4e3442aebdf2cce
Autor:
Kirsten E Lyke, Amy Wang, Abdoulaye Dabo, Charles Arama, Modibo Daou, Issa Diarra, Christopher V Plowe, Ogobara K Doumbo, Marcelo B Sztein
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37868 (2012)
Polyparasitism is common in the developing world. We have previously demonstrated that schistosomiasis-positive (SP) Malian children have age-dependent protection from malaria compared to matched schistosomiasis-negative (SN) children. Evidence of du
Externí odkaz:
https://doaj.org/article/ae2cb3d48af94686baac642135f05bbb
Autor:
Kirsten E Lyke, Matthew Laurens, Matthew Adams, Peter F Billingsley, Adam Richman, Mark Loyevsky, Sumana Chakravarty, Christopher V Plowe, B Kim Lee Sim, Robert Edelman, Stephen L Hoffman
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13490 (2010)
Experimental infection of malaria-naïve volunteers by the bite of Plasmodium falciparum-infected mosquitoes is a preferred means to test the protective effect of malaria vaccines and drugs. The standard model relies on the bite of five infected mosq
Externí odkaz:
https://doaj.org/article/20a1d503d8cf429c8d6f344ba1f7d30d
Autor:
Mahamadou A Thera, Ogobara K Doumbo, Drissa Coulibaly, Matthew B Laurens, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Mady Sissoko, Dapa A Diallo, Issa Diarra, Bourema Kouriba, Modibo Daou, Amagana Dolo, Mounirou Baby, Mahamadou S Sissoko, Issaka Sagara, Amadou Niangaly, Idrissa Traore, Ally Olotu, Olivier Godeaux, Amanda Leach, Marie-Claude Dubois, W Ripley Ballou, Joe Cohen, Darby Thompson, Tina Dube, Lorraine Soisson, Carter L Diggs, Shannon L Takala, Kirsten E Lyke, Brent House, David E Lanar, Sheetij Dutta, D Gray Heppner, Christopher V Plowe
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9041 (2010)
The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria.A Phase 1 double blind randomized controlled dose escalation trial was conducted in Bandia
Externí odkaz:
https://doaj.org/article/cc6d77a455c44be3828ff996e6e1400d
Autor:
Mahamadou A Thera, Ogobara K Doumbo, Drissa Coulibaly, Dapa A Diallo, Abdoulaye K Kone, Ando B Guindo, Karim Traore, Alassane Dicko, Issaka Sagara, Mahamadou S Sissoko, Mounirou Baby, Mady Sissoko, Issa Diarra, Amadou Niangaly, Amagana Dolo, Modibo Daou, Sory I Diawara, D Gray Heppner, V Ann Stewart, Evelina Angov, Elke S Bergmann-Leitner, David E Lanar, Sheetij Dutta, Lorraine Soisson, Carter L Diggs, Amanda Leach, Alex Owusu, Marie-Claude Dubois, Joe Cohen, Jason N Nixon, Aric Gregson, Shannon L Takala, Kirsten E Lyke, Christopher V Plowe
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1465 (2008)
The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria.A phase 1 double blind randomized controlled dose escalation trial was condu
Externí odkaz:
https://doaj.org/article/15ab68b51b8a4e868fb076837e1ef8a9