Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kirsten Deprey"'
Autor:
Charles Abakah, Jiayuan Miao, Kirsten Deprey, James D. Baleja, Adam Moyer, Bryan J. Lampkin, Jennifer R. Pace, David Baker, Yu-Shan Lin, Joshua A. Kritzer, Robert A. Cerulli
Publikováno v:
J Am Chem Soc
Peptides constrained by intramolecular cross-links, especially stapled α-helices, have emerged as versatile scaffolds for drug development. However, there are fewer examples of similarly constrained scaffolds for other secondary structures. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2db5b75ccf8e6895ff17249aed574
https://doi.org/10.1021/jacs.1c04378
https://doi.org/10.1021/jacs.1c04378
Publikováno v:
Nucleic Acids Research
RNA therapeutics are a promising strategy to treat genetic diseases caused by the overexpression or aberrant splicing of a specific protein. The field has seen major strides in the clinical efficacy of this class of molecules, largely due to chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155b472acc5745a6ecbe3df8ec92b162
https://doi.org/10.1093/nar/gkaa576
https://doi.org/10.1093/nar/gkaa576
Autor:
Kirsten Deprey, Nefeli Batistatou, Marjoke F. Debets, Jack Godfrey, Kirstin B. VanderWall, Rebecca R. Miles, Livia Shehaj, Jiaxing Guo, Amy Andreucci, Pachamuthu Kandasamy, Genliang Lu, Mamoru Shimizu, Chandra Vargeese, Joshua A. Kritzer
Publikováno v:
ACS Chem Biol
A major obstacle to the development of effective oligonucleotide therapeutics is a lack of understanding about their cytosolic and nuclear penetration. To address this problem, we have applied the chloroalkane penetration assay (CAPA) to oligonucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca7a1a52699e0b7e5fa1b2efc41faf6
https://europepmc.org/articles/PMC9252293/
https://europepmc.org/articles/PMC9252293/
Autor:
Kirsten Deprey, Joshua A. Kritzer
Publikováno v:
Bioconjug Chem
HaloTag is a modified haloalkane dehalogenase used for many applications in chemical biology including protein purification, cell-based imaging, and cytosolic penetration assays. While working with purified, recombinant HaloTag protein, we discovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1d127eb678f4d7791c27e0d919767b
https://pubmed.ncbi.nlm.nih.gov/33856762
https://pubmed.ncbi.nlm.nih.gov/33856762
Autor:
Conan Wang, David Craik, Joshua Kritzer, Nicholas Condon, Kirsten Deprey, Yen-Hua Huang, Huawu Yin
Cyclotides are macrocyclic peptides that have exceptionally stable structures and been reported to penetrate cells, making them promising scaffolds for the delivery of peptide inhibitory sequences to target intracellular proteins. However, their cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c516cab7ac534ac812a0abad096262a
https://doi.org/10.26434/chemrxiv.11860155
https://doi.org/10.26434/chemrxiv.11860155
Autor:
Joshua A. Kritzer, David J. Craik, Conan K. Wang, Yen-Hua Huang, Huawu Yin, Kirsten Deprey, Nicholas D. Condon
Publikováno v:
ACS Chem Biol
Cyclotides are macrocyclic peptides with exceptionally stable structures and have been reported to penetrate cells, making them promising scaffolds for the delivery of inhibitory peptides to target intracellular proteins. However, their cellular upta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf08540f3d9f0b98bc4031646df3900
https://doi.org/10.26434/chemrxiv.11860155.v1
https://doi.org/10.26434/chemrxiv.11860155.v1
Autor:
Joshua A. Kritzer, Kirsten Deprey
Publikováno v:
Methods Enzymol
A major barrier for drug development is ensuring molecules can access intracellular targets. This is especially true for biomolecules, which are notoriously difficult to deliver to the cytosol. Many current methods for measuring the internalization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b17beb958b8c54d6632f0958f2271a5
https://doi.org/10.1016/bs.mie.2020.03.003
https://doi.org/10.1016/bs.mie.2020.03.003
Autor:
Lydia Atangcho, Tejas Navaratna, Rahul Gopinath, Joshua A. Kritzer, Greg Gueorguiev, Mukesh Mahajan, Greg M. Thurber, Kirsten Deprey, Marshall Case, Hannah Levy
Publikováno v:
SSRN Electronic Journal.
Nearly two-thirds of all disease-associated proteins are ‘undruggable’ by modern therapeutics, meaning they are inside cells, out of the reach of biologics, but lack small molecule binding pockets. Stabilized peptides have the potential to hit th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::194c4172fb3e4f2a4473aaed5257fe28
https://doi.org/10.2139/ssrn.3596598
https://doi.org/10.2139/ssrn.3596598
Biomolecules have many properties that make them promising for intracellular therapeutic applications, but delivery remains a key challenge because large biomolecules cannot easily enter the cytosol. Furthermore, quantification of total intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c75af4f377867e5652cc2de8417741
https://europepmc.org/articles/PMC6527423/
https://europepmc.org/articles/PMC6527423/
Autor:
Joshua A. Kritzer, Kirsten Deprey, Amanda L. Garner, Alyah F. Chmiel, Erin E. Gallagher, Arya Menon
Publikováno v:
Eur J Med Chem
Eukaryotic translation initiation factor 4E (eIF4E) has emerged as a promising cancer therapeutic target due to its role in the initiation of cap-dependent translation, a process that is accelerated during tumorigenesis. To regulate the initiation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a65780748f62d815d86aa2d71b785d1
https://doi.org/10.1016/j.ejmech.2020.112655
https://doi.org/10.1016/j.ejmech.2020.112655