Výsledky vyhledávání - "Kirsten A. Weigel-Van Aken"

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

Autor: Li Zhong, Nicholas Muzyczka, Sergei Zolotukhin, Lakshmanan Govindasamy, Giridhararao Jayandharan, Kirsten A. Weigel-Van Aken, Roland W. Herzog, Cathryn Mah, Baozheng Li, Arun Srivastava, Mavis Agbandje-McKenna, Jacqueline A. Hobbs

Publikováno v: Virology. 381(2):194-202

We have documented that epidermal growth factor receptor protein tyrosine kinase (EGFR-PTK) signaling negatively affects intracellular trafficking and transduction efficiency of recombinant adeno-associated virus 2 (AAV2) vectors. Specifically, inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fa4f0cbae3ffe4dd52c33fe67a39e0

Zobrazit plný text záznamu

Recombinant Self-Complementary Adeno-Associated Virus Serotype Vector-Mediated Hematopoietic Stem Cell Transduction and Lineage-Restricted, Long-Term Transgene Expression in a Murine Serial Bone Marrow Transplantation Model

Autor: Daniela Bischof, Njeri Maina, Kirsten A. Weigel-Van Aken, Li Zhong, Zongchao Han, Zhongbo Hu, Arun Srivastava, Xiaomiao Li, Mervin C. Yoder, William B. Slayton

Publikováno v: Human Gene Therapy. 19:376-383

Although conventional recombinant single-stranded adeno-associated virus serotype 2 (ssAAV2) vectors have been shown to efficiently transduce numerous cells and tissues such as brain and muscle, their ability to transduce primary hematopoietic stem c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ade4fb32a3a2d9426319ccb6e9310ad
https://doi.org/10.1089/hum.2007.143

Zobrazit plný text záznamu

Stable Integration of Recombinant Adeno-Associated Virus Vector Genomes After Transduction of Murine Hematopoietic Stem Cells

Autor: Li Zhong, Kirsten A. Weigel-Van Aken, Zhongbo Hu, Arun Srivastava, William B. Slayton, Xiaomiao Li, Mervin C. Yoder, Nitin Chouthai, Zongchao Han, Daniela Bischof, Njeri Maina

Publikováno v: Human Gene Therapy. 19:267-278

We previously reported that among single-stranded adeno-associated virus (ssAAV) vectors, serotypes 1 through 5, ssAAV1 is the most efficient in transducing murine hematopoietic stem cells (HSCs), but viral second-strand DNA synthesis remains a rate-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d877d25239bc03219ccea1adde5459
https://doi.org/10.1089/hum.2007.161

Zobrazit plný text záznamu

Pharmacological activation of guanine nucleotide exchange factors for the small GTPase Rap1 recruits high-affinity beta1 integrins as coreceptors for parvovirus B19: improved ex vivo gene transfer to human erythroid progenitor cells

Autor: Kirsten A. Weigel-Van Aken

Publikováno v: Human gene therapy. 20(12)

Parvovirus B19 has potential as a gene therapy vector because of its restricted tropism for human erythroid progenitor cells in the bone marrow. B19 binds to the cell surface through P antigen and we identified activated beta(1) integrins as corecept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5ff07f5e8e41c001c506a3346a448f
https://pubmed.ncbi.nlm.nih.gov/19702438

Zobrazit plný text záznamu

Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses

Autor: Sergei Zolotukhin, Li Zhong, Kenneth H. Warrington, Lakshmanan Govindasamy, Nicholas Muzyczka, Arun Srivastava, Irene Zolotukhin, Roland W. Herzog, Mario Cooper, Kirsten A. Weigel-Van Aken, Baozheng Li, Mavis Agbandje-McKenna, Cathryn Mah, Jacqueline A. Hobbs

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 105(22)

Recombinant adeno-associated virus 2 (AAV2) vectors are in use in several Phase I/II clinical trials, but relatively large vector doses are needed to achieve therapeutic benefits. Large vector doses also trigger an immune response as a significant fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf4a65ccb12eb8119e1a4f9b38387aa
https://pubmed.ncbi.nlm.nih.gov/18511559

Zobrazit plný text záznamu

Optimization of recombinant adeno-associated viral vectors for human beta-globin gene transfer and transgene expression

Autor: Daniela Bischof, Sergei Zolotukhin, Li Zhong, Njeri Maina, Mervin C. Yoder, William B. Slayton, Weihong Zhao, Angela Rivers, George Aslanidi, Kirsten A. Weigel-Van Aken, Zongchao Han, Xiaomiao Li, Arun Srivastava

Publikováno v: Human gene therapy. 19(4)

Therapeutic levels of expression of the beta-globin gene have been difficult to achieve with conventional retroviral vectors without the inclusion of DNase I-hypersensitive site (HS2, HS3, and HS4) enhancer elements. We generated recombinant adeno-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998656a6a1bba66287702ae1734c8c7a
https://pubmed.ncbi.nlm.nih.gov/18399730

Zobrazit plný text záznamu

Lactic Acid Induces Aberrant Amyloid Precursor Protein Processing by Promoting Its Interaction with Endoplasmic Reticulum Chaperone Proteins

Autor: Guilian Xu, Kirsten A. Weigel-Van Aken, Yiwen Xiang

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e13820 (2010)

Background Lactic acid, a natural by-product of glycolysis, is produced at excess levels in response to impaired mitochondrial function, high-energy demand, and low oxygen availability. The enzyme involved in the production of β-amyloid peptide (Aβ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81451e311beece2d047f9e3d5a5f5e6
https://doi.org/10.1371/journal.pone.0013820

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání