Changes in immune cell populations following KappaMab, lenalidomide and low‐dose dexamethasone treatment in multiple myeloma

Autor: Samuel E Norton, Tiffany Khong, Malarmathy Ramachandran, Andrew J Highton, Kirsten A Ward‐Hartstonge, Jake Shortt, Andrew Spencer, Roslyn A Kemp

Publikováno v: Clinical & Translational Immunology, Vol 12, Iss 12, Pp n/a-n/a (2023)

Abstract Objectives Lenalidomide (LEN) is used to treat multiple myeloma (MM) and shows in vitro synergy with KappaMab (KM), a chimeric antibody specific for Kappa Myeloma antigen, an antigen exclusively expressed on the surface of kappa‐restricted

Externí odkaz: https://doaj.org/article/3c64e8fff2fb416e86b78486d31102b4

PTEN is required for human Treg suppression of costimulation

Autor: Avery J. Lam, Manjurul Haque, Kirsten A. Ward-Hartstonge, Prakruti Uday, Christine M. Wardell, Jana K. Gillies, Madeleine Speck, Majid Mojibian, Ramon I. Klein Geltink, Megan K. Levings

Regulatory T cell (Treg) therapy is under clinical investigation for the treatment of transplant rejection, autoimmune disease, and graft-versus-host disease. With the advent of genome editing, attention has turned to reinforcing Treg function for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e13a459671c19adc4b4ca6174f8cf63
https://doi.org/10.1101/2022.03.06.483188

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Autor: Lara Gibellini, Sussan Nourshargh, Susanna Cardell, Wlodzimierz Maslinski, Mar Felipo-Benavent, Florian Mair, Hans-Martin Jäck, Lilly Lopez, Klaus Warnatz, John Trowsdale, Diana Ordonez, Marcus Eich, William Hwang, Anne Cooke, Dirk Mielenz, Alberto Orfao, Winfried F. Pickl, Vladimir Benes, Alice Yue, T. Vincent Shankey, Maria Tsoumakidou, Virginia Litwin, Gelo Victoriano Dela Cruz, Andrea Cavani, Sara De Biasi, Larissa Nogueira Almeida, Jonathan J M Landry, Claudia Haftmann, Charlotte Esser, Ana Cumano, Anneke Wilharm, Francesco Dieli, Rudi Beyaert, Alessio Mazzoni, Burkhard Ludewig, Carlo Pucillo, Dirk H. Busch, Joe Trotter, Stipan Jonjić, Marc Veldhoen, Josef Spidlen, Aja M. Rieger, Dieter Adam, Srijit Khan, Todd A. Fehniger, Giuseppe Matarese, Maximilien Evrard, Christian Maueröder, Steffen Schmitt, Kristin A. Hogquist, Barry Moran, Raghavendra Palankar, Markus Feuerer, S Schmid, Susann Rahmig, Amy E. Lovett-Racke, James V. Watson, Megan K. Levings, Susanne Melzer, Dinko Pavlinic, Christopher M. Harpur, Christina Stehle, A. Graham Pockley, Toshinori Nakayama, Attila Tárnok, Juhao Yang, Michael Lohoff, Paulo Vieira, Francisco Sala-de-Oyanguren, Christian Kurts, Anastasia Gangaev, Alfonso Blanco, Hans Scherer, Regine J. Dress, Bruno Silva-Santos, Kiyoshi Takeda, Bimba F. Hoyer, Ilenia Cammarata, Daryl Grummitt, Isabel Panse, Günnur Deniz, Bianka Baying, Friederike Ebner, Esther Schimisky, Leo Hansmann, Thomas Kamradt, Edwin van der Pol, Daniel Scott-Algara, Anna Iannone, Giorgia Alvisi, Sebastian R. Schulz, Francesco Liotta, Irmgard Förster, Beatriz Jávega, Hans-Peter Rahn, Caetano Reis e Sousa, Livius Penter, Xuetao Cao, David P. Sester, Keisuke Goda, Peter Wurst, Iain B. McInnes, Ricardo T. Gazzinelli, Federica Piancone, Gerald Willimsky, Yotam Raz, Pärt Peterson, Wolfgang Fritzsche, Yvonne Samstag, Martin Büscher, Thomas Schüler, Susanne Hartmann, Robert J. Wilkinson, Anna E. S. Brooks, Steven L. C. Ketelaars, Catherine Sautès-Fridman, Anna Rubartelli, Petra Bacher, Katja Kobow, Marco A. Cassatella, Andrea Hauser, Henrik E. Mei, Kilian Schober, Silvia Della Bella, Graham Anderson, Michael D. Ward, Garth Cameron, Sebastian Lunemann, Katharina Kriegsmann, Katarzyna M. Sitnik, Brice Gaudilliere, Chantip Dang-Heine, Marcello Pinti, Paul Klenerman, Frank A. Schildberg, Joana Barros-Martins, Laura G. Rico, Hanlin Zhang, Christian Münz, Thomas Dörner, Jakob Zimmermann, Andrea M. Cooper, Jonni S. Moore, Andreas Diefenbach, Yanling Liu, Wolfgang Bauer, Tobit Steinmetz, Katharina Pracht, Leonard Tan, Peter K. Jani, Alan M. Stall, Petra Hoffmann, Christine S. Falk, Jasmin Knopf, Simon Fillatreau, Hans-Dieter Volk, Luis E. Muñoz, David L. Haviland, William W. Agace, Jonathan Rebhahn, Ljiljana Cvetkovic, Mohamed Trebak, Jordi Petriz, Mario Clerici, Diether J. Recktenwald, Anders Ståhlberg, Tristan Holland, Helen M. McGuire, Sa A. Wang, Christian Kukat, Thomas Kroneis, Laura Cook, Wan Ting Kong, Xin M. Wang, Britta Engelhardt, Pierre Coulie, Genny Del Zotto, Sally A. Quataert, Kata Filkor, Gabriele Multhoff, Bartek Rajwa, Federica Calzetti, Hans Minderman, Cosima T. Baldari, Jens Geginat, Hervé Luche, Gert Van Isterdael, Linda Schadt, Sophia Urbanczyk, Giovanna Borsellino, Liping Yu, Dale I. Godfrey, Achille Anselmo, Rachael C. Walker, Andreas Grützkau, David W. Hedley, Birgit Sawitzki, Silvia Piconese, Maria Yazdanbakhsh, Burkhard Becher, Ramon Bellmas Sanz, Michael Delacher, Hyun-Dong Chang, Immanuel Andrä, Hans-Gustaf Ljunggren, José-Enrique O'Connor, Ahad Khalilnezhad, Sharon Sanderson, Federico Colombo, Götz R. A. Ehrhardt, Inga Sandrock, Enrico Lugli, Christian Bogdan, James B. Wing, Susann Müller, Tomohiro Kurosaki, Derek Davies, Ester B. M. Remmerswaal, Kylie M. Quinn, Christopher A. Hunter, Andreas Radbruch, Timothy P. Bushnell, Anna Erdei, Sabine Adam-Klages, Pascale Eede, Van Duc Dang, Rieke Winkelmann, Thomas Korn, Gemma A. Foulds, Dirk Baumjohann, Matthias Schiemann, Manfred Kopf, Jan Kisielow, Lisa Richter, Jochen Huehn, Gloria Martrus, Alexander Scheffold, Jessica G. Borger, Sidonia B G Eckle, John Bellamy Foster, Anna Katharina Simon, Alicia Wong, Mübeccel Akdis, Gisa Tiegs, Toralf Kaiser, James McCluskey, Anna Vittoria Mattioli, Aaron J. Marshall, Hui-Fern Koay, Eva Orlowski-Oliver, Anja E. Hauser, J. Paul Robinson, Jay K. Kolls, Luca Battistini, Mairi McGrath, Jane L. Grogan, Natalio Garbi, Timothy Tree, Kingston H. G. Mills, Stefan H. E. Kaufmann, Wolfgang Schuh, Ryan R. Brinkman, Tim R. Mosmann, Vincenzo Barnaba, Andreas Dolf, Lorenzo Cosmi, Bo Huang, Andreia C. Lino, Baerbel Keller, René A. W. van Lier, Alexandra J. Corbett, Paul S. Frenette, Pleun Hombrink, Helena Radbruch, Sofie Van Gassen, Olivier Lantz, Lorenzo Moretta, Désirée Kunkel, Kirsten A. Ward-Hartstonge, Armin Saalmüller, Leslie Y. T. Leung, Salvador Vento-Asturias, Paola Lanuti, Alicia Martínez-Romero, Sarah Warth, Zhiyong Poon, Diana Dudziak, Andrea Cossarizza, Kovit Pattanapanyasat, Konrad von Volkmann, Jessica P. Houston, Agnès Lehuen, Andrew Filby, Pratip K. Chattopadhyay, Stefano Casola, Annika Wiedemann, Hannes Stockinger, Jürgen Ruland, Arturo Zychlinsky, Claudia Waskow, Katrin Neumann, Ari Waisman, Lucienne Chatenoud, Sudipto Bari, Kamran Ghoreschi, David W. Galbraith, Yvan Saeys, Hamida Hammad, Andrea Gori, Miguel López-Botet, Gabriel Núñez, Sabine Ivison, Michael Hundemer, Dorothea Reimer, Mark C. Dessing, Günter J. Hämmerling, Rudolf A. Manz, Tomas Kalina, Jonas Hahn, Holden T. Maecker, Hendy Kristyanto, Martin S. Davey, Henning Ulrich, Michael L. Dustin, Takashi Saito, Yousuke Takahama, Milena Nasi, Johanna Huber, Jürgen Wienands, Paolo Dellabona, Andreas Schlitzer, Michael D. Leipold, Kerstin H. Mair, Christian Peth, Immo Prinz, Chiara Romagnani, José M. González-Navajas, Josephine Schlosser, Marina Saresella, Matthias Edinger, Dirk Brenner, Nicole Baumgarth, Rikard Holmdahl, Fang-Ping Huang, Guadalupe Herrera, Malte Paulsen, Gergely Toldi, Luka Cicin-Sain, Reiner Schulte, Christina E. Zielinski, Thomas Winkler, Christoph Goettlinger, Philip E. Boulais, Jennie H M Yang, Antonio Celada, Heike Kunze-Schumacher, Julia Tornack, Florian Ingelfinger, Jenny Mjösberg, Andy Riddell, Leonie Wegener, Thomas Höfer, Christoph Hess, James P. Di Santo, Anna E. Oja, J. Kühne, Willem van de Veen, Mary Bebawy, Alberto Mantovani, Bart Everts, Giovanna Lombardi, Laura Maggi, Anouk von Borstel, Pia Kvistborg, Elisabetta Traggiai, A Ochel, Nima Aghaeepour, Charles-Antoine Dutertre, Matthieu Allez, Thomas Höllt, Wenjun Ouyang, Regina Stark, Maries van den Broek, Shimon Sakaguchi, Paul K. Wallace, Silvano Sozzani, Francesca LaRosa, Annette Oxenius, Malgorzata J. Podolska, Ivana Marventano, Wilhelm Gerner, Oliver F. Wirz, Britta Frehse, Gevitha Ravichandran, Martin Herrmann, Carl S. Goodyear, Gary Warnes, Helen Ferry, Stefan Frischbutter, Tim R. Radstake, Salomé LeibundGut-Landmann, Yi Zhao, Axel Schulz, Angela Santoni, Pablo Engel, Daniela C. Hernández, Andreas Acs, Cristiano Scottà, Francesco Annunziato, Thomas Weisenburger, Wolfgang Beisker, Sue Chow, Fritz Melchers, Daniel E. Speiser, Immanuel Kwok, Florent Ginhoux, Dominic A. Boardman, Natalie Stanley, Carsten Watzl, Marie Follo, Erik Lubberts, Andreas Krueger, Susanne Ziegler, Göran K. Hansson, David Voehringer, Antonia Niedobitek, Eleni Christakou, Lai Guan Ng, Sabine Baumgart, Nicholas A Gherardin, Antonio Cosma, Orla Maguire, Jolene Bradford, Daniel Schraivogel, Linda Quatrini, Stephen D. Miller

Publikováno v: European Journal of Immunology, 49(10), 1457-1973. Wiley-VCH
European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2019, 49 (10), pp.1457-1973. ⟨10.1002/eji.201970107⟩
European Journal of Immunology, 2019, 49 (10), pp.1457-1973. ⟨10.1002/eji.201970107⟩
Eur J Immunol
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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European journal of immunology
European journal of immunology, Vol. 49, no.10, p. 1457-1973 (2019)
EUROPEAN JOURNAL OF IMMUNOLOGY
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Digital.CSIC. Repositorio Institucional del CSIC
Volume 49
Issue 10
European journal of immunology, 49(10), 1457-1973. Wiley-VCH Verlag
European Journal of Immunology, 49(10), 1457-1973
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Cossarizza, A, Chang, H-D, Radbruch, A, Acs, A, Adam, D, Adam-Klages, S, Agace, W W, Aghaeepour, N, Akdis, M, Allez, M, Almeida, L N, Alvisi, G, Anderson, G, Andrä, I, Annunziato, F, Anselmo, A, Bacher, P, Baldari, C T, Bari, S, Barnaba, V, Barros-Martins, J, Battistini, L, Bauer, W, Baumgart, S, Baumgarth, N, Baumjohann, D, Baying, B, Bebawy, M, Becher, B, Beisker, W, Benes, V, Beyaert, R, Blanco, A, Boardman, D A, Bogdan, C, Borger, J G, Borsellino, G, Boulais, P E, Bradford, J A, Brenner, D, Brinkman, R R, Brooks, A E S, Busch, D H, Büscher, M, Bushnell, T P, Calzetti, F, Cameron, G, Cammarata, I, Cao, X, Cardell, S L, Casola, S, Cassatella, M A, Cavani, A, Celada, A, Chatenoud, L, Chattopadhyay, P K, Chow, S, Christakou, E, Čičin-Šain, L, Clerici, M, Colombo, F S, Cook, L, Cooke, A, Cooper, A M, Corbett, A J, Cosma, A, Cosmi, L, Coulie, P G, Cumano, A, Cvetkovic, L, Dang, V D, Dang-Heine, C, Davey, M S, Davies, D, De Biasi, S, Del Zotto, G, Dela Cruz, G V, Delacher, M, Della Bella, S, Dellabona, P, Deniz, G, Dessing, M, Di Santo, J P, Diefenbach, A, Dieli, F, Dolf, A, Dörner, T, Dress, R J, Dudziak, D, Dustin, M, Dutertre, C-A, Ebner, F, Eckle, S B G, Edinger, M, Eede, P, Ehrhardt, G R A, Eich, M, Engel, P, Engelhardt, B, Erdei, A, Esser, C, Everts, B, Evrard, M, Falk, C S, Fehniger, T A, Felipo-Benavent, M, Ferry, H, Feuerer, M, Filby, A, Filkor, K, Fillatreau, S, Follo, M, Förster, I, Foster, J, Foulds, G A, Frehse, B, Frenette, P S, Frischbutter, S, Fritzsche, W, Galbraith, D W, Gangaev, A, Garbi, N, Gaudilliere, B, Gazzinelli, R T, Geginat, J, Gerner, W, Gherardin, N A, Ghoreschi, K, Gibellini, L, Ginhoux, F, Goda, K, Godfrey, D I, Goettlinger, C, González-Navajas, J M, Goodyear, C S, Gori, A, Grogan, J L, Grummitt, D, Grützkau, A, Haftmann, C, Hahn, J, Hammad, H, Hämmerling, G, Hansmann, L, Hansson, G, Harpur, C M, Hartmann, S, Hauser, A, Hauser, A E, Haviland, D L, Hedley, D, Hernández, D C, Herrera, G, Herrmann, M, Hess, C, Höfer, T, Hoffmann, P, Hogquist, K, Holland, T, Höllt, T, Holmdahl, R, Hombrink, P, Houston, J P, Hoyer, B F, Huang, B, Huang, F-P, Huber, J E, Huehn, J, Hundemer, M, Hunter, C A, Hwang, W Y K, Iannone, A, Ingelfinger, F, Ivison, S M, Jäck, H-M, Jani, P K, Jávega, B, Jonjic, S, Kaiser, T, Kalina, T, Kamradt, T, Kaufmann, S H E, Keller, B, Ketelaars, S L C, Khalilnezhad, A, Khan, S, Kisielow, J, Klenerman, P, Knopf, J, Koay, H-F, Kobow, K, Kolls, J K, Kong, W T, Kopf, M, Korn, T, Kriegsmann, K, Kristyanto, H, Kroneis, T, Krueger, A, Kühne, J, Kukat, C, Kunkel, D, Kunze-Schumacher, H, Kurosaki, T, Kurts, C, Kvistborg, P, Kwok, I, Landry, J, Lantz, O, Lanuti, P, LaRosa, F, Lehuen, A, LeibundGut-Landmann, S, Leipold, M D, Leung, L Y T, Levings, M K, Lino, A C, Liotta, F, Litwin, V, Liu, Y, Ljunggren, H-G, Lohoff, M, Lombardi, G, Lopez, L, López-Botet, M, Lovett-Racke, A E, Lubberts, E, Luche, H, Ludewig, B, Lugli, E, Lunemann, S, Maecker, H T, Maggi, L, Maguire, O, Mair, F, Mair, K H, Mantovani, A, Manz, R A, Marshall, A J, Martínez-Romero, A, Martrus, G, Marventano, I, Maslinski, W, Matarese, G, Mattioli, A V, Maueröder, C, Mazzoni, A, McCluskey, J, McGrath, M, McGuire, H M, McInnes, I B, Mei, H E, Melchers, F, Melzer, S, Mielenz, D, Miller, S D, Mills, K H G, Minderman, H, Mjösberg, J, Moore, J, Moran, B, Moretta, L, Mosmann, T R, Müller, S, Multhoff, G, Muñoz, L E, Münz, C, Nakayama, T, Nasi, M, Neumann, K, Ng, L G, Niedobitek, A, Nourshargh, S, Núñez, G, O'Connor, J-E, Ochel, A, Oja, A, Ordonez, D, Orfao, A, Orlowski-Oliver, E, Ouyang, W, Oxenius, A, Palankar, R, Panse, I, Pattanapanyasat, K, Paulsen, M, Pavlinic, D, Penter, L, Peterson, P, Peth, C, Petriz, J, Piancone, F, Pickl, W F, Piconese, S, Pinti, M, Pockley, A G, Podolska, M J, Poon, Z, Pracht, K, Prinz, I, Pucillo, C E M, Quataert, S A, Quatrini, L, Quinn, K M, Radbruch, H, Radstake, T R D J, Rahmig, S, Rahn, H-P, Rajwa, B, Ravichandran, G, Raz, Y, Rebhahn, J A, Recktenwald, D, Reimer, D, Reis E Sousa, C, Remmerswaal, E B M, Richter, L, Rico, L G, Riddell, A, Rieger, A M, Robinson, J P, Romagnani, C, Rubartelli, A, Ruland, J, Saalmüller, A, Saeys, Y, Saito, T, Sakaguchi, S, Sala-de-Oyanguren, F, Samstag, Y, Sanderson, S, Sandrock, I, Santoni, A, Sanz, R B, Saresella, M, Sautes-Fridman, C, Sawitzki, B, Schadt, L, Scheffold, A, Scherer, H U, Schiemann, M, Schildberg, F A, Schimisky, E, Schlitzer, A, Schlosser, J, Schmid, S, Schmitt, S, Schober, K, Schraivogel, D, Schuh, W, Schüler, T, Schulte, R, Schulz, A R, Schulz, S R, Scottá, C, Scott-Algara, D, Sester, D P, Shankey, T V, Silva-Santos, B, Simon, A K, Sitnik, K M, Sozzani, S, Speiser, D E, Spidlen, J, Stahlberg, A, Stall, A M, Stanley, N, Stark, R, Stehle, C, Steinmetz, T, Stockinger, H, Takahama, Y, Takeda, K, Tan, L, Tárnok, A, Tiegs, G, Toldi, G, Tornack, J, Traggiai, E, Trebak, M, Tree, T I M, Trotter, J, Trowsdale, J, Tsoumakidou, M, Ulrich, H, Urbanczyk, S, van de Veen, W, van den Broek, M, van der Pol, E, Van Gassen, S, Van Isterdael, G, van Lier, R A W, Veldhoen, M, Vento-Asturias, S, Vieira, P, Voehringer, D, Volk, H-D, von Borstel, A, von Volkmann, K, Waisman, A, Walker, R V, Wallace, P K, Wang, S A, Wang, X M, Ward, M D, Ward-Hartstonge, K A, Warnatz, K, Warnes, G, Warth, S, Waskow, C, Watson, J V, Watzl, C, Wegener, L, Weisenburger, T, Wiedemann, A, Wienands, J, Wilharm, A, Wilkinson, R J, Willimsky, G, Wing, J B, Winkelmann, R, Winkler, T H, Wirz, O F, Wong, A, Wurst, P, Yang, J H M, Yang, J, Yazdanbakhsh, M, Yu, L, Yue, A, Zhang, H, Zhao, Y, Ziegler, S M, Zielinski, C, Zimmermann, J & Zychlinsky, A 2019, ' Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) ', European Journal of Immunology, vol. 49, no. 10, pp. 1457-1973 . https://doi.org/10.1002/eji.201970107

All authors: Andrea Cossarizza Hyun‐Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam‐Klages William W. Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e44dad3543e0964cf55ab16edc15b2
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85073598520&origin=inward

Prognostic roles for IL ‐2‐producing and CD 69 + T cell subsets in colorectal cancer patients

Autor: Adam Girardin, Shirley Shen, Roslyn A. Kemp, Edward S Taylor, John L. McCall, Fran Munro, Michael A. Black, Kirsten A Ward-Hartstonge

Publikováno v: International Journal of Cancer. 143:2008-2016

Tumor infiltrating T cells are a predictor of patient outcome in patients with colorectal cancer (CRC). However, many T cell populations have been associated with both poor and positive patient prognoses, indicating a need to further understand the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9faa8c6f4b4c976aea6a343e3ccc92a
https://doi.org/10.1002/ijc.31598

Inclusion of BLIMP-1+ effector regulatory T cells improves the Immunoscore in a cohort of New Zealand colorectal cancer patients: a pilot study

Autor: Ann-Kristin Kamps, Fran Munro, Adam Girardin, Erika Cretney, Roslyn A. Kemp, Timothy R. McCulloch, Kirsten A Ward-Hartstonge, John L. McCall

Publikováno v: Cancer Immunology, Immunotherapy. 66:515-522

Analysis of tumour-infiltrating T cells in colorectal cancer can predict disease-free survival. The Immunoscore, obtained by quantifying tumour-infiltrating CD3+ and CD8+ T cells, may improve current staging. Effector regulatory T cells are a potentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ad7c48454bc9de1fb9b58595237d9db
https://doi.org/10.1007/s00262-016-1951-1