Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Kirsten, Timms"'
Autor:
Robert D Morgan, Andrew R Clamp, Bethany M Barnes, Kirsten Timms, Helene Schlecht, Laura Yarram-Smith, Yvonne Wallis, Mikel Valganon-Petrizan, Suzanne MacMahon, Rhian White, Sian Morgan, Sarah McKenna, Emma Hudson, Laura Tookman, Angela George, Ranjit Manchanda, Sudha S Sundar, Shibani Nicum, James D Brenton, Rebecca S Kristeleit, Susana Banerjee, Iain A McNeish, Jonathan A Ledermann, Stephen S Taylor, D Gareth R Evans, Gordon C Jayson
Publikováno v:
Morgan, R D, Clamp, A R, Barnes, B M, Timms, K, Schlecht, H, Yarram-Smith, L, Wallis, Y, Valganon-Petrizan, M, Macmahon, S, White, R, Morgan, S, Mckenna, S, Hudson, E, Tookman, L, George, A, Manchanda, R, Sundar, S S, Nicum, S, Brenton, J D, Kristeleit, R S, Banerjee, S, Mcneish, I A, Ledermann, J A, Taylor, S S, Evans, D G & Jayson, G C 2023, ' Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study ', International Journal of Gynecological Cancer . https://doi.org/10.1136/ijgc-2022-004211
ObjectiveOlaparib plus bevacizumab maintenance therapy improves survival outcomes in women with newly diagnosed, advanced, high-grade ovarian cancer with a deficiency in homologous recombination. We report data from the first year of routine homologo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb793cc9d756983a33fbb917e7372e8
https://doi.org/10.1136/ijgc-2022-004211
https://doi.org/10.1136/ijgc-2022-004211
Autor:
Harsimar B. Kaur, Kirsten Timms, Sanjana Murali, Edward M. Schaeffer, Daniela C. Salles, Olivier Cussenot, Robert S. Brown, Geraldine Cancel-Tassin, William B. Isaacs, Emmanuel S. Antonarakis, Tamara L. Lotan, Jerry S. Lanchbury, Andrea L. Richardson
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
The homologous recombination deficiency (HRD) score integrates three DNA-based measures of genomic instability, and has been understudied in prostate cancer. Given the recent FDA approval of two PARP inhibitors for prostate cancer, HRD score analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de67da26bee656592b7f528616d9a5d
https://doi.org/10.1038/s41379-020-00731-4
https://doi.org/10.1038/s41379-020-00731-4
Autor:
Anil K. Sood, Robert L. Coleman, Selanere Mangala, Placede Tshiaba, Keith A. Baggerly, Wei Hu, Thomas P. Conrads, Kirsten Timms, Chris Neff, Ying Wang, Kari L. Ring, Shannon N. Westin, Karen H. Lu, K.M. Darcy, R.L. Dood, G.L. Maxwell, Russell Broaddus, Gabriel Lopez-Berestein, Shannon Gallagher, Jean H. Siedel
Publikováno v:
Gynecol Oncol
BACKGROUND: Homologous recombination deficiency (HRD) score is related to chemotherapy response in some cancers, but its role in endometrial cancer in not known. We determined frequency and clinical significance of alterations in the HR pathway in en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f9d9905b06c3859fc69b9a152c0c2a
https://doi.org/10.1016/j.ygyno.2020.12.010
https://doi.org/10.1016/j.ygyno.2020.12.010
Autor:
Kirsten Timms, Emmanuel S. Antonarakis, Jessica Hicks, Colin C. Pritchard, Bruce J. Trock, Angelo M. De Marzo, Tamara L. Lotan, Daniela C. Salles, Harsimar B. Kaur, William B. Isaacs, Minh Nguyen, Jerry S. Lanchbury, Sanjana Murali
Publikováno v:
Clinical Cancer Research. 26:4869-4881
Purpose:The ATM (ataxia telangiectasia mutated) gene is mutated in a subset of prostate cancers, and ATM mutation may confer specific therapeutic vulnerabilities, although ATM-deficient prostate cancers have not been well-characterized.Experimental D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de327d31e6624bb2979135861899bdf
https://doi.org/10.1158/1078-0432.ccr-20-0764
https://doi.org/10.1158/1078-0432.ccr-20-0764
Autor:
Noreen Gleeson, John J. O'Leary, Dearbhaile M. O'Donnell, Aoife Carr, Britta K. Stordal, Liam Grogan, Stephen F. Madden, Angela M. Farrelly, Kirsten Timms, Mark Bates, Sinead Toomey, Roshni Kalachand, Bryan T. Hennessy, Ciaran O'Riain, Sharon O'Toole, Oscar S. Breathnach
Publikováno v:
Obstetrics & Gynecology Science
Obstetrics & Gynecology Science, Vol 63, Iss 5, Pp 643-654 (2020)
Obstetrics & Gynecology Science, Vol 63, Iss 5, Pp 643-654 (2020)
Objective\ud The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5836bd99eedc93f18f26704b711d2b6a
http://europepmc.org/articles/PMC7494761
http://europepmc.org/articles/PMC7494761
Autor:
Joshua J. Gruber, Kirsten Timms, Nadine Tung, Vered Stearns, Daniel P. Silver, Andrea L. Richardson, Ryan Bernhisel, Judy Garber, Shaveta Vinayak, James M. Ford, Melinda L. Telli, Virginia G. Kaklamani, Chris Neff, Steven J. Isakoff, Sunil Badve, William J. Gradishar, Sylvia Adams, Roisin M. Connolly, Charles Chu
Publikováno v:
Clinical Cancer Research. 26:2704-2710
Purpose: Patients with triple-negative breast cancer (TNBC) with homologous recombination deficient tumors achieve significantly higher pathologic complete response (pCR) rates when treated with neoadjuvant platinum-based therapy. Tumor-infiltrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d21179047d0138293954b6006b87aea
https://doi.org/10.1158/1078-0432.ccr-19-0664
https://doi.org/10.1158/1078-0432.ccr-19-0664
Autor:
Hillary Zalaznick, Benjamin Clegg, Elizabeth Cogan, Michael Perry, Jeffrey Trost, Debora Mancini-DiNardo, Alexander Gutin, Jerry Lanchbury, Kirsten Timms
Publikováno v:
Gynecologic Oncology. 166:S86-S87
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::885e25028e85fc1989743b249a6e19ef
https://doi.org/10.1016/s0090-8258(22)01365-8
https://doi.org/10.1016/s0090-8258(22)01365-8
Autor:
Yesim Gökmen-Polar, Lajos Pusztai, Richard D. Kennedy, Alastair M. Thompson, Priyanka Sharma, Kirsten Timms, Daniel F. Hayes, Gabriel N. Hortobagyi, Peggy L. Porter, Debu Tripathy, Hannah M. Linden, Shane R. Stecklein, Andrew K. Godwin, William E. Barlow, Sunil Badve
Publikováno v:
Cancer Research. 81:GS3-05
Introduction/Aims: DDIR signature, HRD, and stromal tumor infiltrating lymphocytes (sTIL) have each been associated with favorable outcomes in early stage TNBC. We assessed the overlap between these markers and created prognostic categories based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::339068ff0c5945c2fddea89497cf5ce8
https://doi.org/10.1158/1538-7445.sabcs20-gs3-05
https://doi.org/10.1158/1538-7445.sabcs20-gs3-05
Autor:
Andrew K. Godwin, Lajos Pusztai, Hannah M. Linden, Peggy L. Porter, DB Bailey, Harsh B. Pathak, Debu Tripathy, Gabriel N. Hortobagyi, Kirsten Timms, Robert S. Seitz, Hout, Daniel F. Hayes, C Solimeno, Priyanka Sharma, Alastair M. Thompson, WB Barlow
Publikováno v:
Cancer Research. 79:P4-08
Introduction: TNBC is heterogeneous disease with several molecularly defined subtypes (Lehman et al), each of which may be predictive of response to chemotherapy. TNBC molecular subtypes are associated with varied pathological responses to neoadjuvan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6f85f20df604956f0f30fdd2ebb6688
https://doi.org/10.1158/1538-7445.sabcs18-p4-08-06
https://doi.org/10.1158/1538-7445.sabcs18-p4-08-06
Autor:
Sarah Kernaghan, Judith M Bliss, Kirsten Timms, Mcu Cheang, Holly Tovey, Andrew Tutt, Syed Haider, A Grigoriadis, Salpie Nowinski, O Sipos, C. Toms, Jerry S. Lanchbury, Sabine C. Linn, Sarah E Pinder, Patrycja Gazinska, Investigators, Jelmar Quist
Publikováno v:
Cancer Research. 79:P1-06
Background A distinctive trait of triple negative breast cancer (TNBC) is the acquisition of genome wide highly aberrant copy number states, which is more evident in metastatic settings. The level of copy number alterations can be characterized by qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef0e158f8553bf335febe7b5078dcb3
https://doi.org/10.1158/1538-7445.sabcs18-p1-06-07
https://doi.org/10.1158/1538-7445.sabcs18-p1-06-07