Výsledky vyhledávání - "Kirste J. Mellish"

In vitro photodynamic activity of a series of methylene blue analogues

Autor: Kirste J, Mellish, Russell D, Cox, David I, Vernon, John, Griffiths, Stanley B, Brown

Publikováno v: Photochemistry and photobiology. 75(4)

We have synthesized a series of symmetrical phenothiazines in which the methyl groups of methylene blue have been substituted by longer alkyl chains. Intrinsic photosensitizing ability was not altered by increasing the chain length. However, in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ab0ee27308025319b4c7ceceece53e8
https://pubmed.ncbi.nlm.nih.gov/12003129

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Effect of geometric isomerism in dinuclear platinum antitumour complexes on the rate of formation and structure of intrastrand adducts with oligonucleotides

Autor: Kirste J. Mellish, Yun Qu, Nicholas Farrell, Neel Scarsdale

Publikováno v: Nucleic acids research. 25(6)

The dinuclear platinum complexes [[trans -PtCl (NH3)2]2[mu]-[NH2(CH2) n NH2]](NO3)2[1,1/t,t ( n = 4,6)] and [[cis-PtCl(NH3)2]2[mu];-[NH2(CH2) n NH2](NO3) 2[1,1/c,c ( n = 4,6)] exhibit antitumour activity comparable with cisplatin. 1,1/c,c complexes d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d041b277258f1c399cf2b9716488e2d6
https://pubmed.ncbi.nlm.nih.gov/9092638

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DNA-binding properties of novel cis- and trans platinum-based anticancer agents in 2 human ovarian carcinoma cell lines

Autor: Lloyd R. Kelland, Kirste J. Mellish, Barry A. Murrer, Christopher F. J. Barnard

Publikováno v: International journal of cancer. 62(6)

We have investigated the comparative initial DNA binding properties of 7 platinum-based anticancer drugs: 5 cis-oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [cis ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bis-acetato c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4ea32f315dca6d5f94d96078fad6c0
https://pubmed.ncbi.nlm.nih.gov/7558420

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Circumvention of acquired tetraplatin resistance in a human ovarian carcinoma cell line by a novel trans platinum complex, JM335 [trans ammine (cyclohexylamine) dichloro dihydroxo platinum (IV)]

Autor: Christopher F. J. Barnard, Lloyd R. Kelland, Ken R. Harrap, Kirste J. Mellish

Publikováno v: International journal of cancer. 59(1)

Acquired resistance to tetraplatin [d,1-trans-1,2-diaminocy-clohexane tetrachloroplatinum (IV)] has been generated in vitro in the human ovarian carcinoma cell line PXN94; the derived line, PXN94tetR, was 24-fold resistant to tetraplatin. Intracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3256a7191b5195365b61f9d76817c35b
https://pubmed.ncbi.nlm.nih.gov/7927906

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